Nasopharyngeal cancer: a review of cases at the Korle-Bu Teaching Hospital

Kitcher, ED; Yarney, Joel; Gyasi, RK; Cheyuo, Cletus

doi:10.4314/gmj.v38i3.36004

Cited by 8 publications

(15 citation statements)

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“…Most of the patients presented with advanced disease hence had poor prognosis similar to the findings of Kitcher et al and Iseh et al 18,29 The treatment outcomes of these patients were very unfavourable due to lack of facility to manage them effectively as documented by other researchers. 30 Majority could not afford to travel to the long distances required so as to have radiation therapy while those placed on adjuvant chemotherapy often could not afford the drugs since it was to be paid for through out of pocket expenses due to lack of health insurance.…”

Section: Discussionsupporting

confidence: 71%

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Nasopharyngeal cancers in University of Port Harcourt teaching hospital: a five year review

Uju

2020

Int J Otorhinolaryngol Head Neck Surg

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Background: Nasopharyngeal cancer though an uncommon head and neck cancer, has high morbidity and mortality. It is a cancer that has peculiar geographic variations and hence has been studied by a lot of researchers globally. It however has not been studied as an entity in the South region. This study was to determine the clinical and histologic presentations as well as the prevalence of this disease in Port Harcourt.Methods: Hospital based retrospective review of all patients with confirmed diagnosis of nasopharyngeal cancer seen within the period of January 2014 to December 2018 at ENT Department University of Port Harcourt teaching hospital. The hospital records were the source of data. The demographics, clinical presentations, histology, investigations and outcome were all collated from the records and were analyzed with IBM SPSS version 25. Results: Forty-one patients were studied with age range of 12-85 years. The mean age was 43±15.1 years. Male to female ratio was 1.2:1. Age 40 to 49 years was the most affected. Nasopharyngeal carcinoma was the commonest cancer recorded 68.29% followed by non-Hodgkin’s lymphoma 19.5%. Keratinizing squamous cell carcinoma was the commonest histologic type 43.9%. Commonest symptoms were neck swelling and nasal congestion 24.55%. Age distribution showed a statistical difference with histology of cancer. Mortality of 4.87 was recorded; the rest was lost to follow up.Conclusions: Nasopharyngeal carcinoma is the commonest cancer in the nasopharynx. It is significantly related with age. Patients often present late and it has very high morbidity and mortality rate. Attention to early vague symptoms will enhance early diagnosis, treatment therefore prognosis.

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Section: Discussionsupporting

confidence: 71%

“…27 In contrast, a similar study in Ibadan, Lagos and Ghana had a bimodal age distribution which was not common in low risk areas such as Nigeria and Ghana. 14,28,29 The low risk populations have mono nodal age distribution. 10 The present study similar to others has a male preponderance.…”

Section: Discussionmentioning

confidence: 99%

Nasopharyngeal cancers in University of Port Harcourt teaching hospital: a five year review

Uju

2020

Int J Otorhinolaryngol Head Neck Surg

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“…In Africa, specifically Northern Africa, the yearly incidence of NPC varies between 5 to 7 persons per 100,000 [ 4 ]. NPC is one of the leading cancers in Ghana, with a prevalence of 29% among the head and neck cancers [ 5 ], and about 1.2% of all cancers [ 6 ]. There are ethnic and geographic variations in the occurrence of NPC, which indicates a multifactorial etiology involving EBV infection, genetic susceptibility, ethnicity, environmental factors and food consumption [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Genotypic Characterization of Epstein Barr Virus in Blood of Patients with Suspected Nasopharyngeal Carcinoma in Ghana

Ayee

Ofori

Tagoe

et al. 2020

Viruses

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Nasopharyngeal cancer (NPC) is associated with Epstein Barr virus (EBV) infection. However different viral strains have been implicated in NPC worldwide. This study aimed to detect and characterize EBV in patients diagnosed with NPC in Ghana. A total of 55 patients diagnosed with NPC by CT scan and endoscopy were age-matched with 53 controls without a known oncological disease. Venous blood was collected from the study participants and DNA extracted from the blood samples. Detection of EBV and genotyping were done by amplifying Epstein Barr nuclear antigen 1 (EBNA-1) and Epstein Barr nuclear antigen 2 (EBNA-2), respectively, using specific primers. Viral load in patients and controls was determined using real-time polymerase chain reaction. EBV positivity in controls (92%) was significantly greater than that of NPC patients (67%) (χ2 = 19.17, p < 0.0001), and viral infection was independent of gender (χ2 = 1.770, p = 0.1834). The predominant EBV genotypes in patients and controls were genotype 2 (52%) and genotype 1 (62%), respectively. Median EBV load was significantly higher in NPC patients than the control group (p < 0.01). In summary, prevalence of EBV genotype 2 infection was higher in NPC patients than the control group. Assessment of EBV load may be used as a biomarker for the diagnosis of NPC.

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“…With the current prevalence rate of 29% of all head and neck cancers [22] and 1.2–1.3% of all cancers in Ghana [23], and the number of cases in Korle-Bu Teaching Hospital (KBTH), Ghana, increasing steadily over the last few years, a study in this regard is very necessary to provide baseline data on the presence of HPV and EBV DNA in NPC tissue samples.…”

Section: Introductionmentioning

confidence: 99%

Detection of Human Papillomavirus Genotypes and Epstein-Barr Virus in Nasopharyngeal Carcinomas at the Korle-Bu Teaching Hospital, Ghana

Asante

Asmah

Adjei

et al. 2017

The Scientific World Journal

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Nasopharyngeal carcinomas (NPC) are endemic in Far East Asia and commonly harbour Epstein-Barr virus (EBV) which is known to serve as a key oncogenic promoter. Human papillomavirus (HPV) is known to contribute to the pathogenesis of NPC. However, in Ghana these two viruses have not been linked to NPC prevalence. This study was designed to determine the HPV genotypes and EBV involved in NPC tissue biopsies. A retrospective study design involving 72 formalin-fixed paraffin-embedded tissue (FFPET) samples of NPC from 2006 to 2012 were retrieved from the Department of Pathology, University of Ghana School of Biomedical and Allied Health Sciences. Sections were taken for histological analysis and for DNA lysate preparation. The DNA lysates were subjected to polymerase chain reaction (PCR) analysis to determine the presence of HPV genotypes and EBV. HPV specific primers were used to type for fourteen HPV genotypes (HPV-16, 18, 6/11, 31, 33, 35, 44, 42, 43, 45, 56, 52, 58, and 59). Out of the 72 NPC biopsies analyzed by PCR, EBV DNA was present in 18 (25%) cases and HPV DNA in 14 (19.23%). High risk HPV (HR-HPV) genotypes 18 and 31 were associated with the NPC. There were 3 (4.2%) cases of coinfection by both viruses. The EBV DNA present in the undifferentiated variant of the NPC and the histopathology of the NPC in Ghana is similar to the type described in endemic areas.

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Nasopharyngeal cancer: a review of cases at the Korle-Bu Teaching Hospital

Cited by 8 publications

References 0 publications

Nasopharyngeal cancers in University of Port Harcourt teaching hospital: a five year review

Nasopharyngeal cancers in University of Port Harcourt teaching hospital: a five year review

Genotypic Characterization of Epstein Barr Virus in Blood of Patients with Suspected Nasopharyngeal Carcinoma in Ghana

Detection of Human Papillomavirus Genotypes and Epstein-Barr Virus in Nasopharyngeal Carcinomas at the Korle-Bu Teaching Hospital, Ghana

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