Nasopharyngeal Carcinoma

Mekie, D. E. C.

doi:10.1001/archsurg.1954.01270060083012

Cited by 19 publications

(1 citation statement)

References 3 publications

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“…Kilovoltage machines were developed in the 1920s, but treatment results remained poor because the physical properties of radiation beams generated were far from satisfactory. Patients seldom survived for 3 years [7].…”

Section: Development Of Treatment For Nasopharyngeal Carcinomamentioning

confidence: 99%

Contribution of Radiotherapy to Function Preservation and Cancer Outcome in Primary Treatment of Nasopharyngeal Carcinoma

Lee

2003

World j. surg.

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Development of primary treatment for nasopharyngeal carcinoma is summarized and the contribution of radiotherapy (RT) is reviewed. Accumulation of knowledge, together with technological advances, has led to significant improvement both for tumor control and organ preservation. With contemporary RT, it is possible to achieve a 10-year disease-specific survival of 47% with a severe late complication rate of 5%. Presenting stage is one of the most important prognostic factors, but unfortunately late presentation and delayed diagnosis remains a common problem. The average local control rate is 80% for tumor confined within the nasopharynx, but only 50% for those associated with erosion of the base of the skull or cranial nerve involvement. Nodal deposits from nasopharyngeal carcinoma are much more radiosensitive than those from other head and neck cancers. An average control rate of 75% can be achieved with RT alone, even in patients with nodes > 6 cm in diameter. Successful locoregional control is important, not only because it is crucial for survival but also because it is associated with a lower incidence of distant failure (29% versus 41%). Distant failure remains a sinister problem, especially for patients presenting with advanced T or N-stage cancers. Randomized trials exploring the value of additional chemotherapy are reviewed. The significant improvement in 3-year overall survival achieved by the addition of concurrent and adjuvant chemotherapy (78% versus 47%) recently reported is encouraging, but remaining uncertainties are also discussed.

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Section: Development Of Treatment For Nasopharyngeal Carcinomamentioning

confidence: 99%

Contribution of Radiotherapy to Function Preservation and Cancer Outcome in Primary Treatment of Nasopharyngeal Carcinoma

Lee

2003

World j. surg.

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Cancer of the nasopharynx. Its clinical and radiotherapeutic considerations

Wang

Little

Schulz

1962

Cancer

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Cancer in Singapore children

Muir

1961

Cancer

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ANCER has been held to be much less com-C mon in the East than elsewhere, although the high absolute and relative incidence of certain neoplasms, notably those of the liver163 21 the nasopharynx,Q the chorion,s, 2O and the buccal sulcus,l3 have been well recognized for many years. Moreover, tumors of a major system, such as the gastrointestinal tract, common in certain parts of the East as well as in the West, may show marked geographic differences, e.g., in Singapore, carcinomas of the esophagus are common, those of the colon are rare.10

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Nasopharyngeal Carcinoma

Cited by 19 publications

References 3 publications

Contribution of Radiotherapy to Function Preservation and Cancer Outcome in Primary Treatment of Nasopharyngeal Carcinoma

Contribution of Radiotherapy to Function Preservation and Cancer Outcome in Primary Treatment of Nasopharyngeal Carcinoma

Cancer of the nasopharynx. Its clinical and radiotherapeutic considerations

Cancer in Singapore children

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