Nasopharyngeal carcinoma with cutaneous metastases

Nasopharyngeal carcinoma (NPC) is a squamous cell malignancy originating from the nasopharyngeal epithelium. This tumor is more commonly found originating from the fossa of Rosenmüller, which is a transitional epithelial area. NPC has a high risk of regional metastases on the neck lymphnodes. However, distant metastases at initial diagnosis occur in about 10% of NPC patients. Distant metastases commonly occur in the lung, skeletal bone, and liver, but skin metastases are rare. This case was presented as a case report of a patient with skin metastases in nasopharyngeal carcinoma who had a poor prognosis and distant skin metastases on an NPC patient that was misdiagnosed as a nonmalignant skin lesion. A 46-year-old male NPC patient initially diagnosed as T2N0M0 stage II (two) and received radiotherapy came with a skin lesion during treatment. The skin lesion was then proved as distant skin metastases. Nasopharyngeal carcinoma (NPC) with skin metastases is a rare condition with a poor prognosis, so early detection and proper diagnosis are the first steps towards good therapy.

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“…reported that 4 NPC patients with skin metastases. In 2009, Bohli et al [6] reported 2 cases of NPC with skin metastases.…”

Section: Resultsmentioning

confidence: 99%

Nasopharyngeal Carcinoma with Extensive Nodular Skin Metastasis

Yudistira¹,

Indrasari²,

Herdini³

et al. 2021

Advances in Health Sciences Research

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“…Several studies have shown that up to 9% of cutaneous metastases are associated with head and neck malignancies, the majority from SCC. Therefore, these malignancies should always be considered when the primary cancer is unknown [1]. On average, cutaneous metastasis develops 36 months after the initial diagnosis, though they can present decades later [8,9].…”

Section: Case Discussionmentioning

confidence: 99%

“…Cutaneous metastases are uncommon, accounting for only 2% of all skin cancers and less than 10% of all distant metastatic lesions [1][2][3][4][5]. There is a correlation between the frequency of cutaneous metastasis and the type and prevalence of primary cancer, according to age and sex, with breast and lung cancers being the most common, in women and men, respectively [3,6].…”

Section: Introductionmentioning

confidence: 99%

Cutaneous metastasis of a hypopharyngeal squamous cell carcinoma-unusual presentation

Amoedo¹,

Gomes²,

Coelho³

et al. 2021

Dermatology Online Journal

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“…Distant metastatic sites are usually multifocal, and the lungs, bones, and distant lymph nodes are the most common among these [4][5][6]. Once metastasis occurs, prognosis is usually poor; for example, the survival time from diagnosis for skin metastasis is shorter than nine months [7]. A pediatric nasopharyngeal carcinoma with retinal metastasis had been reported first time in 2009 [8] and a previous 18-year period study founded that NPC was the most common primary cancer that metastasizes to the orbit in southern China [9].…”

Section: Introductionmentioning

confidence: 99%

The predictive value of serum lipids for eye metastases in male nasopharyngeal carcinoma patients

Xie

Shao

2020

Bioscience Reports

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Background: Nasopharyngeal carcinoma (NPC) is a tumor that is commonly found in southern China. NPC has several risk factors, such as infection with the Epstein–Barr virus. However, we know little about the risk factors for eye metastasis (EM) in male patients with NPC. Serum lipids are well recognized as risk factors for cardiovascular disease, and recent studies show that they also have a relationship with the development of NPC. Purpose: We designed the present study to determine whether they were relevant with the development of EM in male NPC patients by detecting the levels of several serum lipids. Methods: A total of 1140 male patients with NPC were enrolled in this retrospective study and we divided them into two groups: the metastasis (EM) group and non-eye metastasis (NEM) group. A variety of serum lipids between the two groups were tested and compared. Results: There were statistical differences in the levels of serum TG and TC between these two groups. Binary logistic regression showed that TG and TC were independent risk factors for EM in male NPC patients with P=0.004 and P<0.001, respectively. The area under the curve of TG and TC were 0.764 and 0.681, respectively, using cutoff values of 0.975 and 3.425 mmol/l, respectively. We found that TG had higher sensitivity and specificity values with 87.5% and 62.7%, respectively, than TC which were 50.0% and 87.2%. Conclusion: TG and TC are potential risk factors for eye metastases in male NPC patients.

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Nasopharyngeal carcinoma with cutaneous metastases

Cited by 6 publications

References 10 publications

Nasopharyngeal Carcinoma with Extensive Nodular Skin Metastasis

Nasopharyngeal Carcinoma with Extensive Nodular Skin Metastasis

Cutaneous metastasis of a hypopharyngeal squamous cell carcinoma-unusual presentation

The predictive value of serum lipids for eye metastases in male nasopharyngeal carcinoma patients

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