Nasopharyngeal carcinoma with hand metastasis

Sipahioğlu, Serkan; Zehir, Sinan; Ozkanli, Ugur

doi:10.1177/1753193412441776

Cited by 6 publications

(3 citation statements)

References 4 publications

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“…An increased vascularity and trauma have been offered as a potential explanation [2,5,6]. Any kind of trauma can lead to the release of prostaglandins and other chemotactic factors that can enhance the cell migration and adhesion in these anatomical regions [9,10]. Literary scrutiny revealed that acrometastasis are frequently associated with Pulmonary cancer (about 36-40%), Gastrointestinal cancer (about 19-20%), and Genitourinary tract neoplasm (10-13%) [3,6].…”

Section: Discussionmentioning

confidence: 99%

Acrometastasis as the First Presentation of Renal Cell Carcinoma

Verma¹,

Mathew²,

Nunoo³

et al. 2023

IJSCR

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Acrometastasis is the term used to describe secondaries present distal to the knee or elbow [1-3]. The occurrence of this is extremely rare. This accounts for 0.1% of all secondaries to the bone [1-5]. The presence of acrometastasis is considered to be a sinistrous sign and correlates with the advanced stage of the disease condition [1, 2, 5]. The majority of acrometastasis is from lung and gastrointestinal malignancies [1-3]. We present a case of a gentleman in his early 60’s, who presented with acrometastasis as the first sign of renal cell carcinoma.

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Section: Discussionmentioning

confidence: 99%

Acrometastasis as the First Presentation of Renal Cell Carcinoma

Verma¹,

Mathew²,

Nunoo³

et al. 2023

IJSCR

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“…Se ha propuesto que este hallazgo estaría explicado por el aumento de flujo sanguíneo hacia la mano dominante y por los mecanismos de angiogénesis involucrados en la respuesta ante trauma en la extremidad, lo que favorecería la siembra de células tumorales hacia distal a partir de tumores primarios 3 . Es más, se ha planteado que mecanismos de quimiotaxis estarían implicados en la ubicación predominante de estas metástasis en falanges de la mano dominante, que tienen mayor perfusión sanguínea en relación a sus similares y mayor exposición a traumatismos, teoría que tomó fuerza a partir de un reporte del año 2005 en que se informa una acrometástasis de adenocarcinoma de colon en un paciente víctima de una mordedura de perro 1,4,5 .…”

Section: Discussionunclassified

Metástasis falángica en dedo anular derecho en paciente con antecedente de cáncer de colon etapa IV

Henríquez Winser,

Figueroa Fernandez,

León Ramírez

2023

Rev Cir.

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Objetivo: Reportar un caso clínico de acrometástasis de cáncer de colon. Materiales y Métodos: Se obtiene información de la ficha clínica electrónica. Se realiza revisión de literatura, utilizando los términos “acrometastasis”, “metástasis óseas”, “metástasis en la mano”, “metástasis en falanges”. Resultados: Se presenta el caso de un paciente con antecedente de cáncer de colon sigmoides etapa IV sometido a resección de metástasis hepáticas, quimioterapia y radioterapia. Consulta por lesión ulcerosa en dedo anular derecho, cuya biopsia indica metástasis de adenocarcinoma de colon. Se realiza amputación transfalángica proximal con biopsia que confirma diagnóstico. Discusión: Las metástasis en mano dan cuenta del 0.007-0.2% de todas las metástasis a distancia. Se presentan como aumento de volumen doloroso de aspecto granulomatoso o asociado a ulceración con empeoramiento progresivo. El tratamiento tiene por objetivo el manejo del dolor y la preservación de la funcionalidad de la extremidad. Conclusión: El adenocarcinoma de colon raramente da metástasis falángicas. Corresponden a una manifestación tardía de la enfermedad con una alta tasa de mortalidad a seis meses asociada. Se deben considerar como diagnóstico diferencial en pacientes oncológicos.

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“…In this systematic review of the literature, 215 studies reported the outcome of 247 patients with multi-organ concurrent metastases, mainly from lung cancer in 91 (36.8%), gastrointestinal cancer in 62 (25.1%), urinary tract cancer in 33 (13.4%), neck cancer in 17 (6.9%), breast cancer in 10 (4.0%), pelvic cancer in 8 (3.2%), skin cancer in 5 (2.0%), bone cancer in 3 (1.2%), blood cancer in 3 (1.2%), mesenchymal cancer in 3 (1.2%), an unknown origin in 3 (1.2%), and other types in 9 (3.6%) patients. The finger/phalanx (68.4%), carpal (14.2%), and metacarpal (14.2%) sites are the prevalent sites of AM because chemotactic factors released after continued traumatisms stimulate the release of prostaglandins, which favor tumor cell adhesion [152,218]. Furthermore, the distal phalanges have higher blood perfusion than the proximal phalanges [153].…”

Section: Pathophysiologymentioning

confidence: 99%

Acrometastases to the Hand: A Systematic Review

et al. 2021

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Background and Objectives: The term acrometastases (AM) refers to secondary lesions sited distally to the elbow and knee, representing 0.1% of all bony metastases. By frequency, pulmonary cancer and gastrointestinal and genitourinary tract neoplasms are the most responsible for the reported AM. Improvements in oncologic patient care favor an increase in the incidence of such rare cases. We performed a systematic review of acrometastases to the hand to provide further insight into the management of these fragile patients. We also present a peculiar case of simultaneous acrometastasis to the ring finger and pathological vertebral fracture. Material and Methods: A literature search according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) statement was conducted using the PubMed, Google Scholar, and Scopus databases in December 2020 on metastasis to the hand and wrist, from 1986 to 2020. MeSH terms included acrometastasis, carpal metastasis, hand metastasis, finger metastasis, phalangeal metastasis, and wrist metastasis. Results: In total, 215 studies reporting the follow-up of 247 patients were analyzed, with a median age of 62 years (range 10–91 years). Overall, 162 out of 247 patients were males (65.6%) and 85 were females (34.4%). The median reported follow-up was 5 months (range 0.5–39). The median time from primary tumor diagnosis to acrometastasis was 24 months (range 0.7–156). Acrometastases were located at the finger/phalanx (68.4%), carpal (14.2%), metacarpal (14.2%), or other sites (3.2%). The primary tumors were pulmonary in 91 patients (36.8%). The average interval from primary tumor diagnosis to acrometastasis varied according to the primary tumor type from 2 months (in patients with mesenchymal tumors) to 64.0 months (in patients with breast cancer). Conclusions: Acrometastases usually develop in the late stage of oncologic disease and are associated with short life expectancy. Their occurrence can no longer be considered rare; physicians should thus be updated on their surgical management and their impact on prognosis and survival.

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Nasopharyngeal carcinoma with hand metastasis

Cited by 6 publications

References 4 publications

Acrometastasis as the First Presentation of Renal Cell Carcinoma

Acrometastasis as the First Presentation of Renal Cell Carcinoma

Metástasis falángica en dedo anular derecho en paciente con antecedente de cáncer de colon etapa IV

Acrometastases to the Hand: A Systematic Review

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