Nasturtium (Indian cress, Tropaeolum majus nanum) dually blocks the COX and LOX pathway in primary human immune cells

Evaluation of an Aqueous Extract from Horseradish Root (Armoracia rusticana Radix) against Lipopolysaccharide‐Induced Cellular Inflammation Reaction

“…This was confirmed by us due to the absence of ITC in the bioactive fraction. A similar observation was made by us earlier using a water extract from nasturtium ( Tropaeolum majus nanum ), which also belongs to the plant order Brassicales [ 10 ]. According to the applied chromatographic separation system, it can be assumed that the target substances in the active extract possess a medium polarity.…”

“…Standardized lyophilized plant powder of the root of horseradish ( Armoracia rusticana Radix, batch number PN19869) that is used in pharmacological remedy was provided by Repha GmbH (Langenhagen, Germany). Plant powder extraction was done as described before [ 10 ]. Briefly, one gram of plant powder was mixed with 10 mL double-distilled water or DMSO and directly incubated at 37°C for 30 min at 100 rpm.…”

“…So far, no scientific data are available which demonstrate the anti-inflammatory potency of horseradish root in a human cell based system or tried to clarify the relevance of allyl ITC for its bioactivity. We recently reported on the anti-inflammatory potential of nasturtium ( Tropaeolum majus nanum ) which also belongs to the plant order Brassicales [ 10 ]. In this study, we could not attribute the bioactivity of nasturtium to ITC formed from the plant.…”

Diverse Excretion Pathways of Benzyl Glucosinolate in Humans after Consumption of Nasturtium (Tropaeolum majus L.)—A Pilot Study

“…In contrast, epithionitriles and CNs show no health promoting potential or even harmful effects such as hepatotoxicity and pancreatic toxicity as observed in vitro, in cattle and rats . Benzyl isothiocyanate (BITC), deriving from benzyl glucosinolate (glucotropaeolin) occurring, e.g., in garden cress ( Lepidium sativum L.), nasturtium ( Tropaeolum majus L.), and papaya ( Carica papaya L.), is well characterized and of great interest due to its antibacterial, anti‐inflammatory, and anti‐diabetogenic activity . Its ability to inhibit cancer development by inferring with cell proliferation and induction of cell cycle arrest and apoptosis is a further valuable property .…”

Solving the puzzle: what is behind our forefathers’ anti-inflammatory remedies?

“…It was initially suggested that the isozyme COX-1 was constitutively expressed in most tissues and involved in the regulation of physiological “housekeeping” (e.g., in the stomach, COX- 1 is important for mucosal fusion, bicarbonate production, and mucus production [ 5 ]) and that COX-2 was an isoform that could be induced in pathological conditions by inflammatory stimulation. Selective COX- 2 inhibitors were developed to prevent gastrointestinal side effects caused by the inhibition of COX-1 [ 88 ]. However, recent studies have demonstrated that COX-1 and COX-2 have overlapping actions and that are both involved in homoeostasis processes.…”