Natamycin: a natural preservative for food applications—a review

Meena, Mahima; Prajapati, Priyanka; Ravichandran, Chandrakala; Sehrawat, Rachna

doi:10.1007/s10068-021-00981-1

Cited by 59 publications

(35 citation statements)

References 81 publications

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“…Antimycin inhibits the mitochondrial electron transport chain between cytochromes b and c [ 41 ]. Natamycin blocks fungal growth when it joins to the ergosterol of the fungus cell membrane [ 42 ]. Neopeptine is an inhibitor of the microbial cell wall biosynthesis at the enzymatic level [ 37 ].…”

Section: Main Actinomycete Antagonistic Mechanisms To Phytopathogenic...mentioning

confidence: 99%

Actinomycete Potential as Biocontrol Agent of Phytopathogenic Fungi: Mechanisms, Source, and Applications

Torres-Rodríguez¹,

Pérez

Quiñones-Aguilar³

et al. 2022

Plants

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Synthetic fungicides have been the main control of phytopathogenic fungi. However, they cause harm to humans, animals, and the environment, as well as generating resistance in phytopathogenic fungi. In the last few decades, the use of microorganisms as biocontrol agents of phytopathogenic fungi has been an alternative to synthetic fungicide application. Actinomycetes isolated from terrestrial, marine, wetland, saline, and endophyte environments have been used for phytopathogenic fungus biocontrol. At present, there is a need for searching new secondary compounds and metabolites of different isolation sources of actinomycetes; however, little information is available on those isolated from other environments as biocontrol agents in agriculture. Therefore, the objective of this review is to compare the antifungal activity and the main mechanisms of action in actinomycetes isolated from different environments and to describe recent achievements of their application in agriculture. Although actinomycetes have potential as biocontrol agents of phytopathogenic fungi, few studies of actinomycetes are available of those from marine, saline, and wetland environments, which have equal or greater potential as biocontrol agents than isolates of actinomycetes from terrestrial environments.

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Section: Main Actinomycete Antagonistic Mechanisms To Phytopathogenic...mentioning

confidence: 99%

Actinomycete Potential as Biocontrol Agent of Phytopathogenic Fungi: Mechanisms, Source, and Applications

Torres-Rodríguez¹,

Pérez

Quiñones-Aguilar³

et al. 2022

Plants

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“…Natamycin is mostly incorporated as a polymer on the contact surface of dairy products. Due to its low solubility, it inhibits yeast growth by binding specifically to ergosterol in the yeast cells without permeabilizing the yeast plasma membrane [ 24 , 31 , 32 ]. Natamycin immobilized on the surface of LDPE film treated for 6 min with UV irradiation demonstrated maximum grafting efficiency (81.96%) and anti-yeast activity against Rhodotorula mucilaginosa and Candida parapsilosis in the disk diffusion test with diameters of 10.62 and 8.06 mm, respectively, and also decreased yeast population in contaminated Iranian yogurt drink (Doogh) from day 0 to day 23 by 52.33% compared to the control sample (increased by 37.86%) [ 15 ].…”

Section: Antifungal Food Packagingmentioning

confidence: 99%

Antibacterial, Antifungal and Antiviral Polymeric Food Packaging in Post-COVID-19 Era

et al. 2022

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Consumers are now more concerned about food safety and hygiene following the COVID-19 pandemic. Antimicrobial packaging has attracted increased interest by reducing contamination of food surfaces to deliver quality and safe food while maintaining shelf life. Active packaging materials to reduce contamination or inhibit viral activity in packaged foods and on packaging surfaces are mostly prepared using solvent casting, but very few materials demonstrate antiviral activity on foods of animal origin, which are important in the human diet. Incorporation of silver nanoparticles, essential oils and natural plant extracts as antimicrobial agents in/on polymeric matrices provides improved antifungal, antibacterial and antiviral properties. This paper reviews recent developments in antifungal, antibacterial and antiviral packaging incorporating natural or synthetic compounds using preparation methods including extrusion, solvent casting and surface modification treatment for surface coating and their applications in several foods (i.e., bakery products, fruits and vegetables, meat and meat products, fish and seafood and milk and dairy foods). Findings showed that antimicrobial material as films, coated films, coating and pouches exhibited efficient antimicrobial activity in vitro but lower activity in real food systems. Antimicrobial activity depends on (i) polar or non-polar food components, (ii) interactions between antimicrobial compounds and the polymer materials and (iii) interactions between environmental conditions and active films (i.e., relative humidity, oxygen and water vapor permeability and temperature) that impact the migration or diffusion of active compounds in foods. Knowledge gained from the plethora of existing studies on antimicrobial polymers can be effectively utilized to develop multifunctional antimicrobial materials that can protect food products and packaging surfaces from SARS-CoV-2 contamination.

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“…Among them, promoter engineering has been proved as a powerful and efficient method to activate or improve the biosynthesis of interest products (Li et al, 2015 , 2017 ). Streptomyces chattanoogensis L10 is an industrial producing strain of natamycin, which is synthesized by type I polyketide synthases and widely used as an antifungal agent in both drug therapy and the food industry (Aparicio et al, 2016 ; Meena et al, 2021 ). Researchers have also activated the cryptic BGCs of chattamycins (Zhou et al, 2015 ) and anthrachamycin (Li et al, 2019 ) in S. chattanoogensis L10 by overexpressing regulatory gene and ribosome engineering, respectively.…”

Section: Introductionmentioning

confidence: 99%

Activation and Characterization of Lanthomicins A–C by Promoter Engineering in Streptomyces chattanoogensis L10

et al. 2022

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The emergence of drug resistance highlights the importance of new drug discovery. Microbial secondary metabolites encoded in biosynthetic gene clusters (BGCs) are a prolific source of drugs, whereas most of these BGCs are cryptic. Thus, taking strategies to activate these cryptic BGCs is of great importance for potential drug discovery. In this work, three novel pentangular polyphenols lanthomicin A–C were identified by activating a cryptic aromatic polyketide BGC through promoter engineering combined with optimization of fermentation conditions. We further confirmed the involvement of lanthomicin (ltm) BGC in biosynthesis by CRISPR-Cpf1-assisted gene editing. Based on functional analysis of homologous genes, a putative biosynthetic pathway was proposed for the three lanthomicins. Particularly, lanthomicin A showed antiproliferative activity with IC50 0.17 μM for lung cancer cell line A-549. The discovery of lanthomicins brings new members to the pentangular polyphenol subclade of aromatic polyketide and demonstrates the potential of Streptomyces as a source for drug discovery.

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Natamycin: a natural preservative for food applications—a review

Cited by 59 publications

References 81 publications

Actinomycete Potential as Biocontrol Agent of Phytopathogenic Fungi: Mechanisms, Source, and Applications

Actinomycete Potential as Biocontrol Agent of Phytopathogenic Fungi: Mechanisms, Source, and Applications

Antibacterial, Antifungal and Antiviral Polymeric Food Packaging in Post-COVID-19 Era

Activation and Characterization of Lanthomicins A–C by Promoter Engineering in Streptomyces chattanoogensis L10

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