National antibiotic resistance monitoring in veterinary pathogens from sick food-producing animals: the German programme and results from the 2001 pilot study

Wallmann, Jürgen; Schröter, Kathrin; Wieler, Lothar H.; Kroker, R.

doi:10.1016/s0924-8579(03)00151-1

Cited by 31 publications

(28 citation statements)

References 10 publications

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“…36 This prevalence of fluoroquinolone resistance is higher than the resistance rate found in other bacterial swine pathogens like Streptococcus suis, 1,23 Arcanobacterium pyogenes, 42 Pasteurella multocida, and Mannheimia haemolytica. 37 Several mechanisms for fluoroquinolone resistance have been described in different bacterial species. These include alterations in the two drug target enzymes, namely DNA gyrase and topoisomerase IV, changes in drug permeation through modifications in the outer membrane proteins, induction of active efflux systems, modifications in the peptidoglycan layer or the outer membrane proteins, 19,28,29 and plasmid-correlated quinolone resistance.…”

Section: Hyopneumoniae Resistance Mechanism 167 Discussionmentioning

confidence: 99%

“…The other five isolates (Mh 7, 10, 11, 15, and 19) were susceptible to flumequine (MIC Յ2 g/ml) and enrofloxacin (MIC Յ0.06 g/ml). 37 …”

Section: Hyopneumoniae Isolatesmentioning

confidence: 99%

“…This rather high frequency was unexpected because fluoroquinolone resistance does not often occur in swine respiratory pathogens. 14,23,37 Fluoroquinolones are broad-spectrum antibiotics. Their use depends on the country regulations; fluoroquinolones are not allowed for use in pigs in the United States but are allowed in the European Union.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Resistance Mechanism Against Fluoroquinolones inMycoplasma hyopneumoniaeField Isolates

Vicca

Maes²,

Stakenborg³

et al. 2007

Microbial Drug Resistance

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The quinolone resistance-determining regions (QRDR) of gyrA, gyrB, parC, and parE of ten Mycoplasma hyopneumoniae field isolates that were either sensitive (5) or resistant (5) to the fluoroquinolones flumequine and enrofloxacin were characterized. In all five resistant isolates, one point mutation (C --> A) in parC was found, resulting in an amino acid change from serine to tyrosine at position 80 (Escherichia coli numbering). For four of these isolates, this was the only mutation found. These isolates had a minimum inhibitory concentration (MIC) of enrofloxacin of 0.5 microg/ml, whereas for sensitive isolates the MIC of enrofloxacin was < or =0.06 microg/ml. One resistant isolate (Mh 20) had an extra mutation (C --> T) in gyrA resulting in an amino acid change from alanine to valine at position 83 (E. coli numbering), leading to a further increase in the MIC of enrofloxacin (>1 microg/ml). No mutations resulting in an amino acid change were detected in the QRDR of the gyrB and parE genes of the selected isolates. This is the first description of the mechanism of stepwise resistance against fluoroquinolones in M. hyopneumoniae.

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Section: Hyopneumoniae Resistance Mechanism 167 Discussionmentioning

confidence: 99%

“…The other five isolates (Mh 7, 10, 11, 15, and 19) were susceptible to flumequine (MIC Յ2 g/ml) and enrofloxacin (MIC Յ0.06 g/ml). 37 …”

Section: Hyopneumoniae Isolatesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Resistance Mechanism Against Fluoroquinolones inMycoplasma hyopneumoniaeField Isolates

Vicca

Maes²,

Stakenborg³

et al. 2007

Microbial Drug Resistance

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“…The German GERM-Vet monitoring programme was established for the purpose of determining the current status of antimicrobial susceptibility of animal pathogens in Germany. This humanveterinary information gathering initiative introduced scientific rigour to the surveillance process, addressing many of the variables that could otherwise confound interpretation of data (Wallmann et al 2003). Within a veterinary framework, Hendriksen et al (2008aHendriksen et al ( , 2008b) surveyed resistance across Europe among bacterial pathogens and indicator bacteria for pigs and cattle.…”

Section: Monitoring Programmes: Points To Considermentioning

confidence: 99%

Antimicrobial Drug Resistance

Martinez

Silley²

2010

Comparative and Veterinary Pharmacology

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This chapter provides an overview of our current understanding of the mechanisms associated with the development of antimicrobial drug resistance, international differences in definitions of resistance, ongoing efforts to track shifts in drug susceptibility, and factors that can influence the selection of therapeutic intervention. The latter presents a matrix of complex variables that includes the mechanism of drug action, the pharmacokinetics (PK) of the antimicrobial agent in the targeted patient population, the pharmacodynamics (PD) of the bacterial response to the antimicrobial agent, the PK/PD relationship that will influence dose selection, and the integrity of the host immune system. Finally, the differences between bacterial tolerance and bacterial resistance are considered, and the potential for non-traditional anti-infective therapies is discussed.

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“…Valid data are necessary to assess the antimicrobial susceptibility of bacterial pathogens in the routine diagnostic laboratory as well as changes in the susceptibility patterns in surveillance and monitoring programmes [3]. Such data can only be generated using standardised procedures for in vitro antimicrobial susceptibility testing [4][5][6][7]. There are several different dilution and diffusion methods that are used in routine diagnostic laboratories to determine the in vitro susceptibility of bacterial pathogens to antimicrobial agents.…”

Section: Introductionmentioning

confidence: 99%

Results of an interlaboratory test on antimicrobial susceptibility testing of bacteria from animals by broth microdilution

Wallmann

Böttner²,

Goossens

et al. 2006

International Journal of Antimicrobial Agents

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National antibiotic resistance monitoring in veterinary pathogens from sick food-producing animals: the German programme and results from the 2001 pilot study

Cited by 31 publications

References 10 publications

Resistance Mechanism Against Fluoroquinolones inMycoplasma hyopneumoniaeField Isolates

Resistance Mechanism Against Fluoroquinolones inMycoplasma hyopneumoniaeField Isolates

Antimicrobial Drug Resistance

Results of an interlaboratory test on antimicrobial susceptibility testing of bacteria from animals by broth microdilution

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