National Cooperative Crohn's Disease Study: Adverse reactions to study drugs

Intestinal Surgery for Crohn’s Disease: Predictors of Recovery, Quality of Life, and Costs

“…1 Surgery is among the most important concerns of patients affected by CD. In fact, concerns about having surgery and having an ostomy bag have a significant impact on health-related quality of life (HRQL) of CD patients, and having surgery increases concerns about body stigma.…”

Oral budesonide for maintenance of remission of Crohn’s disease: a pooled safety analysis

“…Systemic GCSs, such as prednisolone, are effective in high doses for treatment of active disease in patients with CD, 20, 21 but they are frequently associated with clinically important steroid-related AEs. 4 Low doses of systemic GCSs, on the other hand, do not appear to be effective for prolongation of remission. 20,22 Current therapies for maintenance treatment of mild-to-moderate CD are either viewed as safe but of uncertain efficacy or effective but of limited use because of SAEs.…”

“…1 Systemic glucocorticosteroids (GCSs), such as prednisone or prednisolone, are an effective treatment for CD; however, they are associated with clinically important adverse events (AEs), such as adrenal suppression, hypertension, impaired glucose tolerance, cataracts, osteoporosis, osteonecrosis, psychiatric disorders and other cushingoid symptoms. [2][3][4] Thus, although systemic GCSs are efficacious for the treatment of active CD, they are not recommended for long-term treatment of CD.…”

Efficacy of T2 in Active Crohn’s Disease: A Prospective Study Report

“…Controlled studies show that patients with mildly and moderately active CD may respond to corticosteroids [1]. However, corticosteroid treatment cannot be used over a long period without the risk of various steroid-related adverse effects [2]. Nonsteroidal drugs like 5-aminosalicylic acid (5-ASA), azathioprine, 6-mercaptoprine, and infliximab are additional medications for inducing remission [3].…”