National Estimates of Serum Total 25-Hydroxyvitamin D and Metabolite Concentrations Measured by Liquid Chromatography–Tandem Mass Spectrometry in the US Population during 2007–2010

Schleicher, Rosemary L.; Sternberg, Maya; Looker, Anne C.; Yetley, Elizabeth A; Lacher, David A.; Sempos, Christopher T.; Taylor, Christine L.; Durazo‐Arvizu, Ramón; Maw, Khin L; Chaudhary‐Webb, Madhulika; Johnson, Clifford L.; Pfeiffer, Christine M.

doi:10.3945/jn.115.227728

Cited by 203 publications

(150 citation statements)

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“…The 2007–2010 National Health and Nutrition Examination Survey (NHANES) provided the nationally representative serum 25(OH)D concentrations in the US, and seasonal differences in vitamin D status were also observed [18]. In addition, our result was similar to a previous study, which noted that the vitamin D status was poorest during the spring among the elderly population in northern China [19].…”

Section: Discussionsupporting

confidence: 86%

“…The prevalence of vitamin D deficiency peaked at approximately 40 and 50% for men and women, respectively, during the spring season. The prevalence of vitamin D levels <50 nmol/l among Chinese adults is 34.3%, which is similar to that of the Canadian population (36.8%) [16], slightly lower than that of the European population(40.4%) [17] and higher than that of the US population (24%) [18]. In this study, the median 25(OH)D level in Chinese adults was 61.0 nmol/l, which was similar with the studies in the US [18] (median 25(OH)D 3 : 63.6 nmol/l) and Canadian populations (median 25(OH)D: 63.8 nmol/l) [16].…”

Section: Discussionmentioning

confidence: 79%

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Vitamin D status among the elderly Chinese population: a cross-sectional analysis of the 2010–2013 China national nutrition and health survey (CNNHS)

Chen

Yun

et al. 2017

Nutr J

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BackgroundVitamin D inadequacy is common among the elderly, especially within the Asian population. The vitamin D status among healthy adults in the elderly Chinese population was evaluated.MethodsA total of 6014 healthy adults aged 60 years or older (2948 men, 3066 women) participated in this descriptive cross-sectional analysis. Possible predictors of vitamin D inadequacy were evaluated via multiple logistic regression analyses.ResultsThe median serum 25-hydroxyvitamin D (25(OH)D) levels were 61.0 nmol/l (interquartile range (IQR) 44.3–80.6, range 5.1–154.5) for men and 53.7 nmol/l (IQR 38.8–71.0, range 6.0–190.0) for women, with 34.1% (95% confidence interval (CI) 32.4–35.8) of men and 44.0% (95% CI 42.2–45.8) of women presenting vitamin D inadequacy (25(OH)D <50 nmol/l). According to the multivariate logistic regression analyses, vitamin D inadequacy was positively correlated with female gender (P <0.0001), underweight (P = 0.0259), the spring season (P <0.0001), low ambient UVB levels (P <0.0001) and living in large cities (P = 0.0026). For men, vitamin D inadequacy was positively correlated with the spring season (P = 0.0015), low ambient UVB levels (P <0.0001) and living in large cities (P = 0.0022); for women, vitamin D inadequacy was positively correlated with the spring season (P = 0.0005) and low ambient UVB levels (P <.0001).ConclusionsVitamin D inadequacy is prevalent among the elderly population in China. Because residing in regions with low ambient UVB levels increases the risk of vitamin D inadequacy both for men and women, vitamin D supplementation and sensible sun exposure should be encouraged, especially during the cooler seasons. Further studies are required to determine the optimal vitamin D intake and sun exposure levels to maintain sufficient vitamin D levels in the elderly Chinese population.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 79%

Vitamin D status among the elderly Chinese population: a cross-sectional analysis of the 2010–2013 China national nutrition and health survey (CNNHS)

Chen

Yun

et al. 2017

Nutr J

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“…Strict quality control standards and successful participation in an external quality assurance program where target values are aligned to the reference method lend particular strength to our results. Other epidemiologic studies from the USA, Norway and Netherlands that measured 25(OH)D by NIST 972a aligned LC-MS/MS methods found comparable 25(OH)D concentrations [20,31].…”

Section: Discussionmentioning

confidence: 88%

“…Schleicher et al also observed 4 nmol/L higher 25(OH)D concentrations in white American women than in men [31]. In contrast, other studies showed higher levels in males [9,21] or no gender difference [28,32].…”

Section: Discussionmentioning

confidence: 91%

LC–MS/MS based 25(OH)D status in a large Southern European outpatient cohort: gender- and age-specific differences

Giuliani

Barbieri²,

Pierro

et al. 2018

Eur J Nutr

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“…Sources from food and supplements, and sun exposure provide the inert vitamin D2 (ergocalciferol) and D3 (cholecalciferol) forms which undergo a two-step hydroxylation process to produce 25-hydroxyvitamin D [25(OH)D] in the liver and the physiologically active 1,25-dihydroxyvitamin D [1,25(OH) 2 D] in the kidneys (1). In the US, about one-quarter of the population is at risk of inadequacy or deficiency in vitamin D as measured by levels of total serum 25(OH)D (2). Recent studies suggest that vitamin D status may have an impact on fertility, pregnancy, and birth outcomes (3-16).…”

Section: Introductionmentioning

confidence: 99%

Association of vitamin D intake and serum levels with fertility: results from the Lifestyle and Fertility Study

Fung

Hartman

Schleicher

et al. 2017

Fertility and Sterility

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Objective To evaluate the role of vitamin D intake and serum levels on conception of clinical pregnancy and live birth. Design Prospective cohort study. Setting Academic medical centers. Patient(s) Healthy, nulliparous women, aged 18-39 years and their male partners. Intervention(s) None. Main Outcome Measure(s) Clinical pregnancy and live birth were compared between those who did or did not meet the vitamin D Estimated Average Requirement (EAR) intake (10 μg/d), and with serum 25(OH)D considered at risk for inadequacy or deficiency (<50 nmol/L) or sufficient (≥ 50 nmol/L). Results Among 132 women, 37.1% did not meet the vitamin D EAR and 13.9% had serum levels at risk for inadequacy or deficiency. Clinical pregnancies were significantly higher among women who met the vitamin D EAR (67.5% vs. 49.0%) and with sufficient serum 25(OH)D (64.3% vs. 38.9%) compared to those who did not. Live births were higher among those who met the vitamin D EAR (59.0% vs. 40.0%). The adjusted odds ratio (AOR) of conceiving a clinical pregnancy was significantly higher among those who met the EAR (AOR: 2.26, 95% CI 1.05-4.86) and had sufficient serum 25(OH)D (AOR: 3.37, 95% CI 1.06-10.70). The associations were not significant after controlling for selected nutrients and dietary quality. Conclusions Women with vitamin D intake below EAR and serum 25(OH)D levels at risk for inadequacy or deficiency may be less likely to conceive and might benefit from increased vitamin D intake to achieve adequacy. Clinical Trial Registration Number: NCT00642590

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National Estimates of Serum Total 25-Hydroxyvitamin D and Metabolite Concentrations Measured by Liquid Chromatography–Tandem Mass Spectrometry in the US Population during 2007–2010

Cited by 203 publications

References 55 publications

Vitamin D status among the elderly Chinese population: a cross-sectional analysis of the 2010–2013 China national nutrition and health survey (CNNHS)

Vitamin D status among the elderly Chinese population: a cross-sectional analysis of the 2010–2013 China national nutrition and health survey (CNNHS)

LC–MS/MS based 25(OH)D status in a large Southern European outpatient cohort: gender- and age-specific differences

Association of vitamin D intake and serum levels with fertility: results from the Lifestyle and Fertility Study

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