Nanomaterials (NMs) have the potential to be hazardous owing to their unique physico-chemical properties. Therefore, the need for Health Risk Assessment (HRA) of NMs is expanding. In this study, a novel HRA was developed by the Pythagorean Fuzzy Health Risk Assessment (PFHRA) approach. Risk is considered to be the outcome of parameters including Occurrence Likelihood (OL), Potential Exposure (PE) and Toxic Effects (TE). In our proposed method, priority weights of sub-factors in Pythagorean Fuzzy-Analytical Hierarchical Process (PF-AHP) were determined by pairwise comparison based on expert judgment. After determining parameter scores, both RM and risk class (i.e., negligible, minor, major and critical) were reported as Fuzzy Inference System (FIS) output. Ultimately, a risk management strategy is presented for NMs manufacturing workplaces. This proposed method provides experts with more flexibility to express their opinions. The PFHRA approach was applied for two scenarios. The production scenario for SiNPs can create minor (5%) and major (95%) occupational health risks; the production scenario for ZnONPs can create minor (100%) concerns. However, the production SiNPs and ZnONPs utilizing the CB Nanotool technique had a major and minor risk class, respectively. The results of the present study confirmed the reliability and applicability of this approach.