The rapid growth of nanotechnology has increased the occupational exposure to
nanomaterials. On the other hand, a growing body of evidence considers exposure to these
materials to be hazardous. Therefore, it is necessary to examine the effects of
occupational exposure to these materials by different methods. Biological monitoring,
especially the investigation of oxidative stress induced by exposure to nanomaterials, can
provide useful information for researchers. This study systematically reviews studies that
have investigated oxidative stress caused by occupational exposure to nanomaterials. The
search was conducted on the PubMed, Scopus and Web of Science databases. Of the 266
studies we obtained in our initial search, eventually 11 were included in our study. There
is currently no specific biomarker for investigating oxidative stress induced by exposure
to nanomaterials. Therefore, the reviewed studies have used different biomarkers in
different biological fluids for this purpose. Also, the methods of assessing occupational
exposure to nanomaterials in the investigated studies were very diverse. Given the
approach of the investigated studies to biomarkers and exposure assessment methods,
finding a specific biomarker for investigating exposure to nanomaterials seems
unattainable. But reaching a group of biomarkers, to assess exposure to nanomaterials
seems more applicable and achievable.
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