National, regional and global mortality due to alcoholic cardiomyopathy in 2015

Manthey, Jakob; Probst, Charlotte; Rylett, Margaret; Rehm, Jürgen

doi:10.1136/heartjnl-2017-312384

Cited by 34 publications

(24 citation statements)

References 24 publications

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“…Согласно последним эпидемиологическим данным, алкоголь вносит существенный (6,3%) вклад в общее количество случаев смерти от КМП. Выявлена значительная гетерогенность уровня смертности от АКМП: в России отмечаются наибольшие значения данного показателя (163,8 случая на 1 млн населения в год), существенно превышающие аналогичные цифры для большинства других стран и регионов [10]. Причиной отличий в эпидемиологии АКМП может являться разный характер употребления спиртосодержащих напитков в отдельных странах, например, частота запойного потребления алкоголя [5,11].…”

Section: эпидемиологияunclassified

“…К тому же, имеют место недостаточное сообщение об указанной патологии в качестве причины смерти (примерно в каждой второй стране мира), а также вынесение неправильных суждений (до двух третей зарегистрированных случаев) о наличии и степени выраженности АКМП. Это обусловлено низкой частотой выполнения аутопсий во многих странах, cтигматизацией лиц с алкогольной интоксикацией, а также отсутствием четких диагностических критериев для верификации данного заболевания [10,12].…”

Section: эпидемиологияunclassified

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A modern view on the pathogenesis, diagnosis and treatment of alcoholic cardiomyopathy

2019

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Кобалава Ж. Д.-д. м.н., профессор, зав. кафедрой внутренних болезней с курсом кардиологии и функциональной диагностики медицинского института, ORCID: 0000-0003-1126-4282, Лазарев П. В.*-к. м.н., доцент кафедры внутренних болезней с курсом кардиологии и функциональной диагностики медицинского института, ORCID: 0000-0003-4769-5834, Гончаров А. С.-к. м.н., зав. отделением ультразвуковых исследований, ORCID: 0000-0002-7221-2710.

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Section: эпидемиологияunclassified

A modern view on the pathogenesis, diagnosis and treatment of alcoholic cardiomyopathy

2019

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“…A study based on individual‐participant data for nearly 0.6 million consumers showed that even low alcohol consumption was associated with disease risks (Wood et al., ). Alcoholic cardiomyopathy (ACM) is characterized by myocardial degeneration caused by long‐term drinking, which causes the ventricle to dilate, and manifests as cardiac dysfunction (Iacovoni et al., ; Manthey et al., ; Rodrigues et al., ). Approximately one‐half of all cases of dilated cardiomyopathy are reported to be caused by alcohol (George and Figueredo, ; Li et al., ; Weintraub et al., ).…”

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confidence: 99%

AIN‐93 Diet as an Alternative Model to Lieber–DeCarli Diet for Alcoholic Cardiomyopathy

Cao

Zhang

et al. 2019

Alcoholism Clin & Exp Res

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Background: The Lieber-DeCarli alcoholic liquid diet is a classical method for establishing animal models of alcoholic cardiomyopathy (ACM). No study has reported whether the AIN-93 diet, which is widely used as a standard diet for both long-term and short-term studies with laboratory animals, could be used to construct the ACM animal model. The present study intended to investigate whether the AIN-93 diet could be used to establish a mouse ACM model.Methods: Twenty-four C57BL/6 male mice were randomly divided into 4 equally sized groups. In ethanol (EtOH)-fed groups, mice were fed a 4%-EtOH (w/v, 28% of total calories) alcoholic liquid diet of Lieber-DeCarli or the AIN-93 diet for chronic alcohol exposure for 180 days. In control-fed groups, mice were fed with non-EtOH liquid diets with the same calories as EtOH-fed groups. Morphological observations of the hearts and molecular investigation of the brain natriuretic peptide (BNP) were carried out by echocardiography, hematoxylin and eosin (H&E) and immunohistochemistry (IHC) staining, real-time quantitative polymerase chain reaction (qPCR), and enzyme-linked immunosorbent assay.Results: Echocardiography showed that mice fed with either the 4%-EtOH Lieber-DeCarli diet or the 4%-EtOH AIN-93 diet had dilated ventricles and poor cardiac function. IHC staining of BNP, qPCR of BNP mRNA, and plasma concentration of BNP showed an up-regulated expression in mice fed with both the 4%-EtOH Lieber-DeCarli and 4%-EtOH AIN-93 diets. Less fatty liver was also observed in mice fed the AIN-93 alcoholic diet than those fed the Lieber-DeCarli alcoholic diet.Conclusions: The AIN-93 alcoholic liquid diet can be used to establish ACM animal models, as with the conventional Lieber-DeCarli alcoholic liquid diet.

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“…In their Heart paper, Manthey et al published disturbing findings on the worldwide mortality due to alcoholic cardiomyopathy (ACM), incorporating data from death registries for more than 100 countries 7. In 2015, there were more than 27 000 deaths from ACM and this translated into close to 8% of all global deaths from cardiomyopathy being caused by alcohol.…”

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confidence: 99%