2011
DOI: 10.1016/j.joms.2011.03.051
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Nationwide Survey for Bisphosphonate-Related Osteonecrosis of the Jaws in Japan

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Cited by 101 publications
(65 citation statements)
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“…5) Notably, the ratio of the number of BRONJ cases among osteoporotic patients receiving oral N-BPs to that in patients receiving intravenous N-BPs is higher in Japan than in the U.S.A. and EU. 6) The cytotoxicity of N-BPs has been shown to be due to the intracellular inhibition of farnesyl pyrophosphate synthase (FPPS) in the pathway of cholesterol synthesis.…”
mentioning
confidence: 99%
“…5) Notably, the ratio of the number of BRONJ cases among osteoporotic patients receiving oral N-BPs to that in patients receiving intravenous N-BPs is higher in Japan than in the U.S.A. and EU. 6) The cytotoxicity of N-BPs has been shown to be due to the intracellular inhibition of farnesyl pyrophosphate synthase (FPPS) in the pathway of cholesterol synthesis.…”
mentioning
confidence: 99%
“…Il n'existe cependant aucun consensus international. Toutefois, plusieurs articles rĂ©cents montrent des taux plus Ă©levĂ©s de « guĂ©rison » des ostĂ©onĂ©croses aprĂšs traitement chirurgical qu'aprĂšs traitement conservateur, mĂȘme dans les stades prĂ©coces de dĂ©ve-loppement pour lesquels les thĂ©rapeutiques interventionnistes ont Ă©tĂ© longtemps dĂ©conseillĂ©es [19][20][21][22]. Certains auteurs Ă©voquent des traitements complĂ©mentaires comme l'oxygĂ©no-thĂ©rapie hyperbare [23] mais son efficacitĂ© n'est pas prouvĂ©e.…”
Section: Discussionunclassified
“…However, in recent years, serious adverse effects have been viewed with suspicion, and bisphosphonate-related osteonecrosis of the jaws (BRONJ) is an issue of particular concern. The majority of reported cases of bisphosphonate osteonecrosis have been subsequent to dental extractions, intraoral surgical intervention or mucosal trauma (15)(16)(17)(18). BRONJ adversely affects quality of life, producing significant morbidity in afflicted patients (19), and at present, the action mechanism of bisphosphonates is unclear, and their effects on osteoclasts remain evasive.…”
Section: Discussionmentioning
confidence: 99%