Native and recombinant bovine placental lactogens

Álvarez-Oxiley, Andrea; Sousa, Noelita Melo de; Beckers, Jean‐François

doi:10.1016/s1642-431x(12)60006-0

Cited by 14 publications

(10 citation statements)

References 79 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nine placental lactogenes were found to be mouse-specific placenta-predominant expressed genes. Cow and other ruminant species have also undergone expansion of the PRL locus (e.g., PRP1, PRP3, PRP6, PRP10), resulting in the emergence of placental lactogens (e.g., CSH2) (Alvarez-Oxiley et al 2008). …”

Section: Discussionmentioning

confidence: 99%

Elephant Transcriptome Provides Insights into the Evolution of Eutherian Placentation

Hou

Sterner

Romero

et al. 2012

Genome Biology and Evolution

View full text Add to dashboard Cite

The chorioallantoic placenta connects mother and fetus in eutherian pregnancies. In order to understand the evolution of the placenta and provide further understanding of placenta biology, we sequenced the transcriptome of a term placenta of an African elephant (Loxodonta africana) and compared these data with RNA sequence and microarray data from other eutherian placentas including human, mouse, and cow. We characterized the composition of 55,910 expressed sequence tag (i.e., cDNA) contigs using our custom annotation pipeline. A Markov algorithm was used to cluster orthologs of human, mouse, cow, and elephant placenta transcripts. We found 2,963 genes are commonly expressed in the placentas of these eutherian mammals. Gene ontology categories previously suggested to be important for placenta function (e.g., estrogen receptor signaling pathway, cell motion and migration, and adherens junctions) were significantly enriched in these eutherian placenta–expressed genes. Genes duplicated in different lineages and also specifically expressed in the placenta contribute to the great diversity observed in mammalian placenta anatomy. We identified 1,365 human lineage–specific, 1,235 mouse lineage–specific, 436 cow lineage–specific, and 904 elephant-specific placenta-expressed (PE) genes. The most enriched clusters of human-specific PE genes are signal/glycoprotein and immunoglobulin, and humans possess a deeply invasive human hemochorial placenta that comes into direct contact with maternal immune cells. Inference of phylogenetically conserved and derived transcripts demonstrates the power of comparative transcriptomics to trace placenta evolution and variation across mammals and identified candidate genes that may be important in the normal function of the human placenta, and their dysfunction may be related to human pregnancy complications.

show abstract

Section: Discussionmentioning

confidence: 99%

Elephant Transcriptome Provides Insights into the Evolution of Eutherian Placentation

Hou

Sterner

Romero

et al. 2012

Genome Biology and Evolution

View full text Add to dashboard Cite

show abstract

“…Some years ago the noted Canadian scientist, Tom Wegman declared that "the fetus is bathed in cytokines". However, the amniotic fluid contains the most prolactin in the body and is also very rich in placental lactogenic hormones [5] and steroid hormones and other mediators [6]. Clearly the amniotic fluid contains numerous important biological regulators.…”

Section: Editors In Chiefmentioning

confidence: 99%

“…A likely source of most of these mediators is the placenta as it transforms into an endocrine organ with the aim of protecting the fetus against maternal influences and interests [5,6].…”

Section: Editors In Chiefmentioning

confidence: 99%

Feto-Marenal Interactions – Undisputable Evidence for the Concept of Neuroimmune Biology

Berczi

Katafuchi²

2011

Advances in Neuroimmune Biology

View full text Add to dashboard Cite

“…A higher rate of lipolysis, associated with the transition period, can downregulate PON1 synthesis. Providing a proinflammatory ambient causes a release of adipokines that have an influence in the enzymatic synthesis (KOSKINEN et al, 2011). Alvarez (2008 reported that the bPL concentrations can vary according to the corporal condition; however, this was not observed in this study because of the homogeneity of the selected cows (HIGH,BCS=2,9±0,05;MEDIUM,BCS=3,1±0,03,and LOW,BCS=2,9±0,05).…”

Section: Introductionmentioning

confidence: 99%

“…Hossner et al (1997) reported that the bPL concentrations in the maternal serum was less than 5 ng mL -1 and can be detected after the first gestation month. At the end of gestational period, the increase in the fetal cortisol reduces the serum bPL levels drastically by inhibiting the release of hormone from the storage granules of binucleated cells (ALVAREZ-OXILEY et al, 2008). In previous studies, the maximum concentration of LP did not exceed 3 ng mL -1 in the last three weeks that preceded parturition; this concentration was much lower than the levels of LP in other animals such as sheep, goats, humans, and small rodents (WALLACE, 1993).…”

Section: Introductionmentioning

confidence: 99%

Paraoxonase activity in the serum of peripartum dairy cows with different placental lactogen concentrations

Rohenkohl

Lopes

Barbosa

et al. 2017

SCA

View full text Add to dashboard Cite

The action of the bovine placental lactogen (bPL) hormone on maternal metabolism is still poorly known. Some markers, such as the acute phase protein paraoxonase (PON1), are used as indicators of liver function and help to determine the metabolic condition during the transition period in dairy cows. The aim of this study was to evaluate the activity of paraoxonase (PON1) in the serum of peripartum dairy cows with different levels of bPL. Based on the plasma bPL concentration, 18 cows were divided equally into three groups: LOW ( < 2,68 ng bPL mL -1 ), MEDIUM (2,68-2,80 ng bPL mL -1 ), and HIGH ( > 2,80 ng bPL mL -1 ). The experiment was conducted between 21 days prepartum and 28 days postpartum. Serum samples were collected during the experiment for the determination of bPL concentrations and PON1 activity. The bPL concentration was significantly different between the experimental groups (P ≤ 0,0001) and the days of serum collection (P ≤ 0,0001). In the prepartum dairy cows, the PON1 levels were different between the groups (P ≤ 0,05) and the days of serum collection (P ≤ 0,05). Cows with high bPL concentration had lower serum PON1 activity (P ≤ 0,05), while cows with low hormone levels had higher enzyme activity (P ≤ 0,05). In the postpartum period, there was a significant difference between the days of serum collection (P ≤ 0,0001) and the interaction between groups and collections (P ≤ 0,01). The group with high concentrations of bPL had lower levels of PON1 (P ≤ 0,01), while the group with low bPL maintained higher concentrations of PON1 (P ≤ 0,01). It was concluded that the cows with higher concentrations of bPL in the prepartum period present a reduction in the serum activity of the PON1 enzyme during the peripartum period. Key words: Hormones. Inflammation. Proteins. Transition period. ResumoA ação do hormônio Lactogênio Placentário Bovino (bLP) no metabolismo materno ainda é pouco conhecida. Alguns marcadores, como a proteína de fase aguda Paraoxanase (PON1), são utilizados como indicadores da função hepática auxiliando na determinação da condição metabólica no período

show abstract

Native and recombinant bovine placental lactogens

Cited by 14 publications

References 79 publications

Elephant Transcriptome Provides Insights into the Evolution of Eutherian Placentation

Elephant Transcriptome Provides Insights into the Evolution of Eutherian Placentation

Feto-Marenal Interactions – Undisputable Evidence for the Concept of Neuroimmune Biology

Paraoxonase activity in the serum of peripartum dairy cows with different placental lactogen concentrations

Contact Info

Product

Resources

About