1997
DOI: 10.1038/ki.1997.320
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Natriuretic peptide receptors mediate different responses in rat renal microvessels

Abstract: Atrial natriuretic peptide (ANP) has unique effects on the renal vasculature, in that it dilates preglomerular vessels and constricts efferent arterioles. In the present study we aimed to characterize the natriuretic peptide receptor (NPR) subtypes, which mediate the renovascular effects of ANP, using in vivo microscopy in the split hydronephrotic kidney model of rats. ANP (10(-9) and 3.10(-9)), which binds to NPR-A and NPR-C, dilated preglomerular vessels and constricted efferent arterioles similarly to that … Show more

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Cited by 30 publications
(19 citation statements)
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“…Surprisingly, the signal transduction pathway mediating ANP-induced vasoconstriction has been suggested to involve GC activation and subsequent cGMP production (11). This is consistent with our finding that the ANP-antagonist A71915, which blocks the production of cGMP by ANP, completely inhibits ANP-induced vasoconstriction of the splenic vasculature (28).…”
supporting
confidence: 89%
See 1 more Smart Citation
“…Surprisingly, the signal transduction pathway mediating ANP-induced vasoconstriction has been suggested to involve GC activation and subsequent cGMP production (11). This is consistent with our finding that the ANP-antagonist A71915, which blocks the production of cGMP by ANP, completely inhibits ANP-induced vasoconstriction of the splenic vasculature (28).…”
supporting
confidence: 89%
“…Although ANP is typically considered to be a vasodilator (15), there is evidence that this peptide has vasoconstrictor actions on the mesenteric, renal, and splenic vasculature (11,28,(32)(33)(34). For example, ANPinduced increases in glomerular filtration rate are mediated via the vasoconstrictor action of ANP on the renal efferent arterioles (12,(19)(20)(21).…”
mentioning
confidence: 99%
“…ANP selectively dilates preglomerular vessels and constricts efferent arterioles, thereby increasing the filtration fraction (FF). If the glomerular filtration rate (GFR) and tubular reabsorption of sodium (Na ϩ ) remain constant, this increase in FF would provide an increased filtered load (FL) of Na ϩ , resulting in natriuresis (12).…”
mentioning
confidence: 99%
“…Natriuretic peptide-mediated constriction of the efferent arterioles concomitant to dilation of the afferent renal arterioles have been well documented in animal experimentations (27)(28)(29)(30). A slower time course of atrial natriuretic peptide-induced vasoconstriction of efferent arterioles, compared with a prompt vasodilatory response of the afferent arterioles in pre-constricted preparations, has been reported by Camargo et al (30) in isolated, perfused rat kidneys and has been suggested to be the result of a secondary release of endothelin (31,32).…”
Section: Discussionmentioning
confidence: 87%