Natural ACE inhibitory peptides discovery from Spirulina (Arthrospira platensis) strain C1

Anekthanakul, Krittima; Senachak, Jittisak; Hongsthong, Apiradee; Charoonratana, Tossaton; Ruengjitchatchawalya, Marasri

doi:10.1016/j.peptides.2019.170107

Cited by 45 publications

(23 citation statements)

References 50 publications

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“…Spirulina extracts have been reported to possess anti-inflammatory properties and its potential use in humans and mechanism as an anti-inflammatory agent has been demonstrated successfully [18] . Moreover, Spirulina nutraceuticals and derived ACE inhibitory peptides have been well demonstrated for boosting immune response, reduction in cytokine related inflammation, and enhancing ACE2 activity in in-vitro, in-vivo, and in-silico studies on model animal organisms and humans in different diseases [ 18 , [47] , [48] , [49] , [50] ]. Heo et al, [49] investigated the potential of ACE inhibitory peptide from hydrolyzed Spirulina sp.…”

Section: Introductionmentioning

confidence: 99%

“…Similarly, both the hydrolysates were able to inhibit ACE activity in cellular assays in Caco-2 cells with IC 50 values of 2.7 ± 0.3 mg mL −1 and 2.8 ± 0.9 mg mL −1 respectively. Anekthanakul et al [48] developed a “SpirPep” platform to assist in silico-based bioactive peptides discovery of bioactive compounds from Spirulina . They showed that peptides derived from Spirulina were mainly involved in the ACE inhibitory activity.…”

Section: Introductionmentioning

confidence: 99%

“…They reported two new ACE substrate binding sites (R124 and S219) along with binding sites residues (D121, E123, S516, and S517) from natural ACE inhibitory peptides (angiotensin II and bradykinin-potentiating peptides) through which “SpirPep1” indirectly bound to ACE. Natural ACE inhibitory peptides from Spirulina have great potential in ACE inhibition and enhancing ACE2 activity [48] .…”

Section: Introductionmentioning

confidence: 99%

“…ACE-Is are generally used for enhancing ACE2 activity for the treatment of tissue injury in various organs in severe cases of coronavirus infection. Since, different studies have shown potential applications of Spirulina derived ACE inhibitory peptides as an anti-inflammatory and antioxidative agent via enhancing ACE2 activity and reducing cytokine related inflammation [ 18 , [47] , [48] , [49] , [50] ]. Therefore, based on these studies, it can be postulated that supplementation of Spirulina derived ACE inhibitory peptides may play a potential therapeutic or subsidiary role in the alleviation and treatment of oxidative stress, cytokine release syndrome, and tissue injury in SARS-CoV2 and other coronavirus infections through the regulation of ACE2 activity ( Fig.…”

Section: Introductionmentioning

confidence: 99%

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Prospective options of algae-derived nutraceuticals as supplements to combat COVID-19 and human coronavirus diseases

et al. 2021

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Prospective options of algae-derived nutraceuticals as supplements to combat COVID-19 and human coronavirus diseases

et al. 2021

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“…Spirulina is a prokaryotic photosynthetic microbe that belongs to the phylum Cyanophyta and has up to 60–70% protein content and a significant amino acid composition [1]. Other bioactive compounds included in it are γ‐linolenic acid, sulfoquinovosyl diacylglycerols, carotenoids, and polysaccharides.…”

Section: Introductionmentioning

confidence: 99%

Effects of different probiotic combinations on the components and bioactivity of Spirulina

et al. 2020

J Basic Microbiol

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Spirulina acts as a good dietary nutritional supplement. However, few research studies have been conducted on its fermentation. Three groups of probiotic combinations, lactic acid bacteria, Bacillus strains, and their mixture, were used to investigate Spirulina fermentation. The results showed that lactic acid bacteria significantly increased the content of amino acids and the ratio of essential amino acids to total amino acids in the fermented Spirulina, compared with the unfermented Spirulina, and this trend was enhanced by the strains' mixture. However, compared to unfermented Spirulina, the amino acid levels were significantly decreased after fermentation with Bacillus strains and so was the total free amino acid and essential amino acid content. Fermentation significantly reduced the contents of the offensive components of Spirulina, with significant differences among the three mixed bacterial treatments. Moreover, Bacillus strain fermentation increased the contents of flavonoids and polyphenols compared to the unfermented Spirulina, and significantly enhanced 1,1‐diphenyl‐2‐trinitrophenylhydrazine free‐radical scavenging ability and total antioxidant ability. On the contrary, treatments with lactic acid bacteria and the mixture of lactic acid bacteria and Bacillus strains endowed the fermented supernatants with good antibacterial ability. The results showed that probiotic fermentation has a good effect on Spirulina and can serve as a new procedure for developing new Spirulina‐containing food items.

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Big Things, Small Packages: An Update on Microalgae as Sustainable Sources of Nutraceutical Peptides for Promoting Cardiovascular Health

et al. 2023

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In 2017, a review of microalgae protein‐derived bioactive peptides relevant in cardiovascular disease (CVD) management was published. Given the rapid evolution of the field, an update is needed to illumininate recent developments and proffer future suggestions. In this review, the scientific literature (2018–2022) is mined for that purpose and the relevant properties of the identified peptides related to CVD are discussed. The challenges and prospects for microalgae peptides are similarly discussed. Since 2018, several publications have independently confirmed the potential to produce microalgae protein‐derived nutraceutical peptides. Peptides that reduce hypertension (by inhibiting angiotensin converting enzyme and endothelial nitric oxide synthase), modulate dyslipidemia and have antioxidant and anti‐inflammatory properties have been reported, and characterized. Taken together, future research and development investments in nutraceutical peptides from microalgae proteins need to focus on the challenges of large‐scale biomass production, improvement in techniques for protein extraction, peptide release and processing, and the need for clinical trials to validate the claimed health benefits as well as formulation of various consumer products with the novel bioactive ingredients.

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Natural ACE inhibitory peptides discovery from Spirulina (Arthrospira platensis) strain C1

Cited by 45 publications

References 50 publications

Prospective options of algae-derived nutraceuticals as supplements to combat COVID-19 and human coronavirus diseases

Prospective options of algae-derived nutraceuticals as supplements to combat COVID-19 and human coronavirus diseases

Effects of different probiotic combinations on the components and bioactivity of Spirulina

Big Things, Small Packages: An Update on Microalgae as Sustainable Sources of Nutraceutical Peptides for Promoting Cardiovascular Health

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