Natural biomarocmolecule-based antimicrobial hydrogel for rapid wound healing: A review

Farazin, Ashkan; Shirazi, Fatemeh; Shafiei, Morvarid

doi:10.1016/j.ijbiomac.2023.125454

Cited by 39 publications

(5 citation statements)

References 102 publications

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“…Developments in biomaterials have provided us more options for wound repair materials such as nanofibers, membranes, foams, powders and hydrogels. Among these, hydrogels have high hydrophilicity, good biocompatibility and biodegradability, ion transport ability, and similar structures to the ECM, make hydrogels have great application potential as wound management materials [ 67 ]. In addition, the main chain molecules of polymer hydrogels can be chemically modified to endow the hydrogel with injectability, self-healing properties, antibacterial activity, antioxidant activity and other properties which can give benefit to wound healing.…”

Section: Biomimetic Biomaterials Mimic Morphological Structure and Ti...mentioning

confidence: 99%

Advances and applications of biomimetic biomaterials for endogenous skin regeneration

Wang,

Hong,

et al. 2024

Bioactive Materials

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Section: Biomimetic Biomaterials Mimic Morphological Structure and Ti...mentioning

confidence: 99%

Advances and applications of biomimetic biomaterials for endogenous skin regeneration

Wang,

Hong,

et al. 2024

Bioactive Materials

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“…Bacterial cell membranes and airborne fungal spores typically carry negative charges, while many viruses also exhibit negatively charged surfaces in aqueous solutions [66]. Therefore, cationic compounds can effectively bind to these pathogens, inhibiting their growth or killing them [67]. Among these compounds, chitosan, which is derived from chitin and is abundant in amino groups, has been widely applied in the construction of hydrogels with antimicrobial activity.…”

Section: Hydrogels With Inherent Anti-infection Performancementioning

confidence: 99%

Dynamic Hydrogels against Infections: From Design to Applications

Zhang,

Zhu

2024

Gels

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Human defense against infection remains a global topic. In addition to developing novel anti-infection drugs, therapeutic drug delivery strategies are also crucial to achieving a higher efficacy and lower toxicity of these drugs for treatment. The application of hydrogels has been proven to be an effective localized drug delivery approach to treating infections without generating significant systemic adverse effects. The recent emerging dynamic hydrogels further show power as injectable formulations, giving new tools for clinical treatments. In this review, we delve into the potential applications of dynamic hydrogels in antibacterial and antiviral treatments and elaborate on their molecular designs and practical implementations. By outlining the chemical designs underlying these hydrogels, we discuss how the choice of dynamic chemical bonds affects their stimulus responsiveness, self-healing capabilities, and mechanical properties. Afterwards, we focus on how to endow dynamic hydrogels with anti-infection properties. By comparing different drug-loading methods, we highlight the advantages of dynamic chemical bonds in achieving sustained and controlled drug release. Moreover, we also include the design principles and uses of hydrogels that possess inherent anti-infective properties. Furthermore, we explore the design principles and applications of hydrogels with inherent anti-infective properties. Finally, we briefly summarize the current challenges faced by dynamic hydrogels and present a forward-looking vision for their future development. Through this review, we expect to draw more attention to these therapeutic strategies among scientists working with chemistry, materials, as well as pharmaceutics.

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“… 16 Incorporating nanoparticles imparts these hydrogels with antimicrobial properties, accelerating the healing process and reducing the risk of infections. 17 Moreover, the mechanical strength of nanocomposite hydrogels enhances their suitability for wound dressings, supporting the injured area while promoting tissue regeneration. The synergistic combination of enhanced mechanical properties and tailored drug release kinetics ensures that these biomaterials address multiple facets of wound care, resulting in improved therapeutic outcomes.…”

Section: Introductionmentioning

confidence: 99%

Revolutionizing biomedicine: advancements, applications, and prospects of nanocomposite macromolecular carbohydrate-based hydrogel biomaterials: a review

Alshangiti,

El-damhougy,

Zaher

et al. 2023

RSC Adv.

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Natural biomarocmolecule-based antimicrobial hydrogel for rapid wound healing: A review

Cited by 39 publications

References 102 publications

Advances and applications of biomimetic biomaterials for endogenous skin regeneration

Advances and applications of biomimetic biomaterials for endogenous skin regeneration

Dynamic Hydrogels against Infections: From Design to Applications

Revolutionizing biomedicine: advancements, applications, and prospects of nanocomposite macromolecular carbohydrate-based hydrogel biomaterials: a review

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