Natural Chagas disease in four baboons

Williams, Jeff T.; Dick, Edward J.; VandeBerg, John L.; Hubbard, Gene B.

doi:10.1111/j.1600-0684.2008.00308.x

Cited by 27 publications

(28 citation statements)

References 42 publications

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“…cruzi from the United States can cause disease and death. 5 These data suggest that the biological characteristics of T . cruzi isolates from the United States may vary considerably.…”

mentioning

confidence: 80%

“…However, > 1,000 seropositive persons have been detected during routine screening of blood donations in the United States since 2007. 3 Although few autochthonous human cases in the United States have been reported, reports of domestic dog and captive exotic animal cases are increasing, 4,5 and the prevalence of T . cruzi in wild mammal reservoir species can be as high as in South America.…”

mentioning

confidence: 99%

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Infectivity, Pathogenicity, and Virulence of Trypanosoma cruzi Isolates from Sylvatic Animals and Vectors, and Domestic Dogs from the United States in ICR Strain Mice and SD Strain Rats

Roellig¹,

Yabsley²

2010

The American Society of Tropical Medicine and Hygiene

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Abstract. Trypanosoma cruzi , the causative agent of Chagas disease, is widespread in the southern United States. In addition to detection in numerous wildlife host species, cases have been diagnosed in domestic dogs and humans. In the current investigation, groups of laboratory mice [Crl:CD1 (ICR)] were inoculated with one of 18 United States T. cruzi isolates obtained from a wide host range to elucidate their infectivity, pathogenicity, and virulence. In addition, laboratory rats (SD strain) were inoculated with four isolates. Mice and rats were susceptible to infection with all strains, but no morbidity or mortality was noted, which indicates that these T. cruzi isolates from the United States had low virulence for laboratory mice and rats.

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“…cruzi from the United States can cause disease and death. 5 These data suggest that the biological characteristics of T . cruzi isolates from the United States may vary considerably.…”

mentioning

confidence: 80%

mentioning

confidence: 99%

Infectivity, Pathogenicity, and Virulence of Trypanosoma cruzi Isolates from Sylvatic Animals and Vectors, and Domestic Dogs from the United States in ICR Strain Mice and SD Strain Rats

Roellig¹,

Yabsley²

2010

The American Society of Tropical Medicine and Hygiene

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“…Trypanosoma cruzi infection is also widespread among a variety of wild and domestic animals, including non-human primates that are maintained in endemic areas 5–8. Endemic infections of T. cruzi in dogs and wild animals have been found in Alabama, Arizona, California, Florida, Georgia, Louisiana, New Mexico, Texas, and even as far north as Maryland.…”

Section: Introductionmentioning

confidence: 99%

Nonspecific Lymphocytic Myocarditis in Baboons Is Associated with Trypanosoma cruzi Infection

Andrade

Dick

Guardado-Mendoza

et al. 2009

The American Journal of Tropical Medicine and Hygiene

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Non-specific lymphocytic myocarditis (NLM) is frequently observed in baboons within the endemic range of Trypanosoma cruzi. We sought to determine whether T. cruzi infection is a cause of baboon NLM. We evaluated serial histologic sections of cardiac muscle, blood cultures, immunohistochemistry, serology, polymerase chain reaction, and clinical pathology from 31 baboons with NLM to determine whether T. cruzi infection is associated with NLM. Eleven baboons with no evidence of T. cruzi infection by serology and no NLM were used as controls. Seropositivity for T. cruzi was 45% in baboons with NLM compared with a 2-3% colony prevalence. NLM lesion severity was significantly higher in seropositive than seronegative baboons with NLM. NLM was significantly more common in older baboons. No statistical association between NLM and sex, weight, or clinical pathology was found. These results suggest an association between NLM and T. cruzi infection in the baboon.

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“…In the order Carnivora, dogs (family Canidae) and cats (fam- (450). The demonstrated high prevalence rates indicate the importance of primates in the maintenance of the T. cruzi cycle in the surroundings of modern cities.…”

Section: Orders Of Mammals Infected By Trypanosoma Cruzimentioning

confidence: 99%

Pathogenesis of Chagas' Disease: Parasite Persistence and Autoimmunity

et al. 2011

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SUMMARY Acute Trypanosoma cruzi infections can be asymptomatic, but chronically infected individuals can die of Chagas' disease. The transfer of the parasite mitochondrial kinetoplast DNA (kDNA) minicircle to the genome of chagasic patients can explain the pathogenesis of the disease; in cases of Chagas' disease with evident cardiomyopathy, the kDNA minicircles integrate mainly into retrotransposons at several chromosomes, but the minicircles are also detected in coding regions of genes that regulate cell growth, differentiation, and immune responses. An accurate evaluation of the role played by the genotype alterations in the autoimmune rejection of self-tissues in Chagas' disease is achieved with the cross-kingdom chicken model system, which is refractory to T. cruzi infections. The inoculation of T. cruzi into embryonated eggs prior to incubation generates parasite-free chicks, which retain the kDNA minicircle sequence mainly in the macrochromosome coding genes. Crossbreeding transfers the kDNA mutations to the chicken progeny. The kDNA-mutated chickens develop severe cardiomyopathy in adult life and die of heart failure. The phenotyping of the lesions revealed that cytotoxic CD45, CD8 + γδ, and CD8α + T lymphocytes carry out the rejection of the chicken heart. These results suggest that the inflammatory cardiomyopathy of Chagas' disease is a genetically driven autoimmune disease.

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Natural Chagas disease in four baboons

Cited by 27 publications

References 42 publications

Infectivity, Pathogenicity, and Virulence of Trypanosoma cruzi Isolates from Sylvatic Animals and Vectors, and Domestic Dogs from the United States in ICR Strain Mice and SD Strain Rats

Infectivity, Pathogenicity, and Virulence of Trypanosoma cruzi Isolates from Sylvatic Animals and Vectors, and Domestic Dogs from the United States in ICR Strain Mice and SD Strain Rats

Nonspecific Lymphocytic Myocarditis in Baboons Is Associated with Trypanosoma cruzi Infection

Pathogenesis of Chagas' Disease: Parasite Persistence and Autoimmunity

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