Natural chlorins as a promising platform for creating targeted theranostics in oncology

Grin, Mikhail A.; Suvorov, Nikita; Миронов, А. Ф.

doi:10.1016/j.mencom.2020.07.003

Cited by 12 publications

(5 citation statements)

References 61 publications

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“…Inverse electron demand Diels-Alder reactions are used to modify the pigments. It was previously shown that this reaction occurred in high yields and had a few advantages over other methods for modifying chlorophyll a derivative [97,98]. We are currently planning to study the photoinduced toxicity of the PS obtained against Gram-positive and Gram-negative bacteria to identify the structure-activity relationship.…”

Section: Antimicrobial Cationic Derivatives Of Natural Chlorinsmentioning

confidence: 99%

Derivatives of Natural Chlorophylls as Agents for Antimicrobial Photodynamic Therapy

Suvorov

Pogorilyy

Diachkova

et al. 2021

IJMS

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The rapid growth of drug-resistant bacteria all over the world has given rise to a major research challenge, namely a search for alternative treatments to which bacteria will be unable to develop resistance. Photodynamic therapy is an approach of this kind. It involves the use of photosensitizers in combination with visible light at a certain wavelength to excite the former and generate reactive oxygen species. Various synthetic heterocyclic compounds are used as photosensitizers. Of these, derivatives of natural chlorophylls have a special place due to their properties. This review deals with the use of such compounds in antimicrobial PDT.

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Section: Antimicrobial Cationic Derivatives Of Natural Chlorinsmentioning

confidence: 99%

Derivatives of Natural Chlorophylls as Agents for Antimicrobial Photodynamic Therapy

Suvorov

Pogorilyy

Diachkova

et al. 2021

IJMS

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“…PDT has several advantages: It is non-invasive, painlessness, no side effects on the healthy tissues and organs, has the possibility of combination with other treatment methods, and it also could enhance the immune response against cancer cells [ 1 , 2 , 3 , 4 ]. However, the development of PDT is hampered by the drawbacks of PSs, currently used in clinical practice [ 2 , 5 ]; thus, researchers worldwide are looking for ways to create new and more effective PSs [ 5 , 6 , 7 , 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Nanoparticles of N-Vinylpyrrolidone Amphiphilic Copolymers and Pheophorbide a as Promising Photosensitizers for Photodynamic Therapy: Design, Properties and In Vitro Phototoxic Activity

et al. 2023

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A series of nanoparticles (NPs) with a hydrodynamic radius from 20 to 100 nm in PBS was developed over the solubilization of hydrophobic dye methyl pheophorbide a (chlorin e6 derivative) by amphiphilic copolymers of N-vinylpyrrolidone with (di)methacrylates. Photophysical properties and biological activity of the NPs aqueous solution were studied. It was found that the dye encapsulated in the copolymers is in an aggregated state. However, its aggregation degree decreases sharply, and singlet oxygen quantum yield and the fluorescence signal increase upon the interaction of these NPs with model biological membranes—liposomes or components of a tissue homogenate. The phototoxic effect of NPs in HeLa cells exceeds by 1.5–2 times that of the reference dye chlorin e6 trisodium salt—one of the most effective photosensitizers used in clinical practice. It could be explained by the effective release of the hydrophobic photosensitizer from the NPs into biological structures. The demonstrated approach can be used not only for the encapsulation of hydrophobic photosensitizers for PDT but also for other drugs, and N-vinylpyrrolidone amphiphilic copolymers show promising potential as a modern platform for the design of targeted delivery vehicles.

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“…However, the interest of scientists for studying the properties of these unique molecules is the same [3]. The promising catalytic properties of porphyrins make it possible to use them in various fields of chemical technology [4][5][6], biology, and medicine, for example, in photodynamic therapy [7][8][9], as photosensitisers in systems for converting solar (I)…”

Section: Introductionmentioning

confidence: 99%

Assessment of polyfunctional macrocyclic compounds in solution by cryoscopic method

Berezina,

Kolesov

2023

From Chemistry Towards Technology Step-by-Step

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The article considers the synthesis of meso-tetrakis(1'-methyl-pyrid-4-yl)porphyrin tetratosylate and meso-tetrakis(1'-methyl-carboxymethylpyrid-4-yl)porphyrin tetrabromide. The authors qualified the porphyrin ligands in terms of the electron and 1H NMR spectroscopy. The research determines the decrease of freezing point (ΔTfr) of aqueous solutions of porphyrins, as well as a model N-methyl-pyridinium salt (1 methyl-pyridinium iodide). We used the obtained experimental values of ΔT3 to determine the isotonic coefficient. The obtained results indicate the compounds are almost completely dissociated in the indicated concentration range in dilute solutions.

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Natural chlorins as a promising platform for creating targeted theranostics in oncology

Cited by 12 publications

References 61 publications

Derivatives of Natural Chlorophylls as Agents for Antimicrobial Photodynamic Therapy

Derivatives of Natural Chlorophylls as Agents for Antimicrobial Photodynamic Therapy

Nanoparticles of N-Vinylpyrrolidone Amphiphilic Copolymers and Pheophorbide a as Promising Photosensitizers for Photodynamic Therapy: Design, Properties and In Vitro Phototoxic Activity

Assessment of polyfunctional macrocyclic compounds in solution by cryoscopic method

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