2019
DOI: 10.1007/s12272-019-01150-z
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Natural compound inducers of immunogenic cell death

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Cited by 47 publications
(28 citation statements)
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“…Numerous nano-based chemotherapeutic delivery systems have been devised mostly for the purpose of targeted tumor destruction but little attention has been paid to their immune activities though immune effects are implicated in the anti-tumor efficacy of certain chemotherapeutic agents [10]. We had also fabricated polyglycerol-functionalized nanodiamonds carrying doxorubicin (Nano-DOX) for tumor-targeted delivery of doxorubicin (DOX) [11].…”
Section: Introductionmentioning
confidence: 99%
“…Numerous nano-based chemotherapeutic delivery systems have been devised mostly for the purpose of targeted tumor destruction but little attention has been paid to their immune activities though immune effects are implicated in the anti-tumor efficacy of certain chemotherapeutic agents [10]. We had also fabricated polyglycerol-functionalized nanodiamonds carrying doxorubicin (Nano-DOX) for tumor-targeted delivery of doxorubicin (DOX) [11].…”
Section: Introductionmentioning
confidence: 99%
“…39 Here, we summarized previous achievements in the development of curcumin as a modulator of the tumor immune system. The plasticity, polarization, and function of tumor-associated macrophages (TAMs), 40 modulation of Tregs, 26 and modulation of the immunogenicity of dying cancer cells, 27 along with the TME 41 49 Thus, curcumin dose should be carefully considered when used as an immunomodulator. Evidence of the immune modulation properties of curcumin in vitro and in vivo is summarized in Table 1.…”
Section: Curcuminmentioning
confidence: 99%
“…In addition to the earlier mentioned natural products, there are some several others that have not mentioned, such as polysaccharides (e.g., mushroom extract), anthracyclines, polyunsaturated fatty acids, ginger, which have been previously described. 26,27 Here, the parent review just briefly summarized part natural products, reported in previous reviews.…”
Section: Other Natural Productsmentioning
confidence: 99%
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“…Interestingly, several drug combinations were particularly effective in killing CRCs harboring mutant KRAS/BRAF or SPOP through elevated ER stress and DR5 expression 91,92 . Various natural compounds, epigenetic drugs, and oncolytic viruses can also induce or enhance ICD 93‐95 . Anticancer efficacy observed was associated with increased CD8+ T cells, 76 tumor cell CRT exposure and HMGB1 release, 96 or activation of endogenous retroviruses and IFN signaling 97,98 …”
Section: Icd‐inducing Agents In Crc Prevention and Therapymentioning
confidence: 99%