Natural compounds from traditional medicinal herbs in the treatment of cerebral ischemia/reperfusion injury

Abstract

More and more attention in the field of drug discovery has been focused on the neuroprotection of natural compounds from traditional medicinal herbs. Cerebral ischemia is a complex pathological process involving a series of mechanisms, and a framework for the development of neuroprotectants from traditional herb medicine is a promising treatment for cerebral ischemia. Natural compounds with the effects of anti-oxidation, anti-inflammation, calcium antagonization, anti-apoptosis, and neurofunctional regulation exhibit preventive or therapeutic effects on experimental ischemic brain injury. According to the pharmacological mechanisms underlying neuroprotection, we evaluated natural products from traditional medicinal herbs that exhibit protective effects on ischemic brain injury and characterized the promising targets.

African eggplant (Solanum anguivi Lam.) fruit with bioactive polyphenolic compounds exerts in vitro antioxidant properties and inhibits Ca2+-induced mitochondrial swelling

“…In the present study, we used Ca 2+ to induce MPTP opening. Recently, antioxidants from medicinal plants with calcium antagonization effect [49] and ROS scavengers have been proposed to be promising inhibitor of MPTP opening from a clinical perspective [50] . In the present study, SAG extract did not have any effect on mitochondrial membrane potential nor MPTP under basal condition.…”

Neuroprotective effect of safranal, an active ingredient of Crocus sativus , in a rat model of transient cerebral ischemia

“…However, the reestablishment of oxygen may exacerbate ischemic injury by the generation of inflammatory mediators and toxic levels of oxidative free radicals, terminating in lipid peroxidation, protein synthesis arrest, and finally, cell death [8,19]. Currently, in the field of drug discovery for the treatment of cerebral ischemia/reperfusion injury (IRI), more and more attention is paid to the neuroprotection of natural compounds from traditional medicinal herbs [32].…”

The protective effect of qiancao naomaitong mixture on neuronal damage and cerebral ischemia/reperfusion injury

“…It shows a trend of increasing incidence rate each year and has become one of the major diseases with high morbidity and mortality (Zhou et al 2008;Lakhan et al 2009;Wu et al 2010). Recent studies on the mechanism of ischemic brain injury have made rapid progress, demonstrating that factors such as neuronal damage caused by free radicals, excitatory amino acid toxicity, inflammation and cell apoptosis play important roles during the process of ischemic brain injury (Ritz et al 2008;Mukerji et al 2009).…”