Fluid flow and natural convection heat transfer in a parallelogram enclosure with an inner circular cylinder using Cu-water nanofluid are studied numerically. Dimensionless Navier-Stokes and energy equations are solved numerically using finite element method based two-dimensional flow and steady-state conditions. This study evaluates the effect of different concentrations of Cu-water nanofluids (0% to 6%) with different Rayleigh numbers 10 3 ≤ Ra ≤ 10 6 under isotherm wall temperatures. The effects of geometrical parameters of the parallelogram enclosure (inclination angle in range of 0 ≤ α≤ 30 and location of inner circular cylinder-0.2 ≤ H ≤ +0.2 on the flow field and heat transfer are examined. The results are presented in terms of streamlines, isotherms, local and average Nusselt number. It is found that the inclination angle has a significant effect on flow pattern and heat transfer and the inclination angle of 30 o at a vertical location H=-0.2 gives better fluid flow strength. Moreover, the maximum heat transfer enhancement is obtained when the circular cylinder moves vertically downward up to H=-0.1 and the inclination angle is 30 o. The results also indicate that as the Rayleigh number, nanofluid concentration increase, the rate of heat transfer will increase.