Natural course of sensitization to food and inhalant allergens during the first 6 years of life

Kulig, Michael; Bergmann, Renate L.; Klettke, Uwe; Wahn, V.; Tacke, Uta; Wahn, Ulrich

doi:10.1016/s0091-6749(99)70195-8

Cited by 417 publications

(305 citation statements)

References 19 publications

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“…Entre os alimentos, o leite de vaca foi o mais identificado, seguido por clara de ovo, trigo, peixe e soja (Tabela 7). Em geral, as proteínas do leite de vaca são as primeiras proteínas heterólogas da dieta com as quais os lactentes entram em contato, o que justifica a sensibilização a elas em fase precoce da vida 23 . Nesta população, observamos predomínio de sensibilização ao leite de vaca entre as crianças com idade inferior a 2 anos, enquanto que a sensibilização ao peixe ocorreu nas crianças mais velhas, posto que a introdução deste alimento na dieta ocorre geralmente após o primeiro ano de vida.…”

Section: Controles Alérgicosunclassified

Sensitization to inhalant and food allergens in Brazilian atopic children by <i>in vitro</i> total and specific IgE assay. Allergy Project - PROAL

et al. 2004

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Fonte financiadora: Pharmacia do Brasil (doou kits para dosagens).Artigo submetido em 015.12.03, aceito em 03.03.04. AbstractObjective: To determine the frequency of sensitization to inhalant and food allergens in children seen at Brazilian allergy services.Patients and methods: Total and specific IgE serum levels to inhalant and food allergens (RAST, UniCAP ® Pharmacia) were measured in 457 children accompanied in pediatric allergy services and in 62 control children age matched. RAST equal or higher than class 1 was considered as positive (R+).Results: Frequency of R+ was significantly higher among atopics (361/457, 79%) when compared to controls (16/62, 25.8%). There were no differences according to gender. The frequency of R+ to all allergens evaluated were higher among atopics when compared to controls. Significantly higher total IgE serum levels were observed among the atopics with R+ in comparison to those with R-. The frequency of R+ to main inhalant allergens were: D. pteronyssinus = 66.7% x 14.5% (p < 0.05), D. farinae = 64.5% x 17.8% (p < 0.05), B. tropicalis = 55.2% x 19.4% (p < 0.05), cockroach = 32.8% x 9.7% (p < 0.05), and cat = 12% x 8.1%. In relation to food allergens we observed: fish = 29.5% x 11.3% (p < 0.05), egg = 24.4% x 4.8% (p < 0.05), cow s milk = 23.1% x 3.2% (p < 0.05), wheat = 20% x 8.1% (p < 0.05), peanuts = 14% x 4.8% (p < 0.05), soy = 11.8% x 4.8% (p < 0.05), and corn = 10.6% x 4.8% (p < 0.05). With respect of age, food allergen sensitization predominates in young children whereas the inverse occurs with inhalant allergens.Conclusions: There was a predominant frequency of sensitization to inhalant allergens, mainly house dust mites in the evaluated patients. Food allergens were also responsible for a significant proportion of sensitization, mainly in infants. ResumoObjetivo: Determinar a freqüência de sensibilização a alérgenos inalantes e alimentares em crianças atendidas em serviços brasileiros de alergia. Pacientes e métodos: IgE sérica total e específica (RAST) a alérgenos inalantes e alimentares (UniCAP ® Pharmacia) foram determinados em 457 crianças acompanhadas em serviços de alergia pediátrica e em um grupo de controles (n = 62). Resultados classe igual ou maior que 1 foram considerados positivos (R+).Resultados: A freqüência de R+ foi significantemente maior entre os atópicos (361/457, 79%) quando comparados aos controles (16/62, 25,8%). Não houve diferenças quanto ao sexo. A prevalência de R+ entre os atópicos foi significantemente maior para todos os alérgenos avaliados. Os níveis séricos de IgE total foram significantemente mais elevados entre os atópicos com R+ quando comparados aos com R-. Comparando-se atópicos e controles, a freqüência de R+ para os principais alérgenos inalantes foi como segue: D. pteronyssinus = 66,7 versus 14,5% (p < 0,05), D. farinae = 64,5 versus 17,8% (p < 0,05), B. tropicalis = 55,2 versus 19,4% (p < 0,05), barata = 32,8 versus 9,7% (p < 0,05) e gato = 12 versus 8,1%. Com os alimentos, observouse: peixe = 29,5 versus 11,3% (p < 0,05), ovo =...

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Section: Controles Alérgicosunclassified

Sensitization to inhalant and food allergens in Brazilian atopic children by <i>in vitro</i> total and specific IgE assay. Allergy Project - PROAL

et al. 2004

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“…During the ®rst months of life, the ®rst IgE responses to food proteins develop (Fig. 2a), particularly those to hen's egg and cow's milk (10). Even in completely breast-fed infants, high amounts of speci®c serum IgE antibodies to hen's egg may be detected.…”

Section: The Natural History Of Atopic Diseasesmentioning

confidence: 99%

What drives the allergic march?

Wahn

2000

Allergy

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“…In general cow s milk proteins are the first heterologous dietary proteins with which infants come into contact, which explains early sensitization. 23 Within this population we observed a predominance of sensitization to cow s milk among children less than two years old and sensitization to fish occurred among older children, bearing in mind that the introduction of this element into the diet generally occurs after one year of life. We did not detect any differences in sensitization prevalence to the different allergens according to patient region of origin.…”

Section: Controlsmentioning

confidence: 61%

Sensibilização a alérgenos inalantes e alimentares em crianças brasileiras atópicas, pela determinação in vitro de IgE total e específica: Projeto Alergia (PROAL)

Naspitz¹,

Solé²,

Jacob³

et al. 2004

J. Pediatr. (Rio J.)

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Objective: To determine the frequency of sensitization to inhalant and food allergens in children seen at Brazilian allergy services.Patients and methods: Total and specific IgE serum levels to inhalant and food allergens (RAST, UniCAP ® Pharmacia) were measured in 457 children accompanied in pediatric allergy services and in 62 control children age matched. RAST equal or higher than class 1 was considered as positive (R+).Results: Frequency of R+ was significantly higher among atopics (361/457, 79%) when compared to controls (16/62, 25.8%). There were no differences according to gender. The frequency of R+ to all allergens evaluated were higher among atopics when compared to controls. Significantly higher total IgE serum levels were observed among the atopics with R+ in comparison to those with R-. The frequency of R+ to main inhalant allergens were: D. pteronyssinus = 66.7% x 14.5% (p < 0.05), D. farinae = 64.5% x 17.8% (p < 0.05), B. tropicalis = 55.2% x 19.4% (p < 0.05), cockroach = 32.8% x 9.7% (p < 0.05), and cat = 12% x 8.1%. In relation to food allergens we observed: fish = 29.5% x 11.3% (p < 0.05), egg = 24.4% x 4.8% (p < 0.05), cow s milk = 23.1% x 3.2% (p < 0.05), wheat = 20% x 8.1% (p < 0.05), peanuts = 14% x 4.8% (p < 0.05), soy = 11.8% x 4.8% (p < 0.05), and corn = 10.6% x 4.8% (p < 0.05). With respect of age, food allergen sensitization predominates in young children whereas the inverse occurs with inhalant allergens.Conclusions: There was a predominant frequency of sensitization to inhalant allergens, mainly house dust mites in the evaluated patients. Food allergens were also responsible for a significant proportion of sensitization, mainly in infants.

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Natural course of sensitization to food and inhalant allergens during the first 6 years of life

Cited by 417 publications

References 19 publications

Sensitization to inhalant and food allergens in Brazilian atopic children by <i>in vitro</i> total and specific IgE assay. Allergy Project - PROAL

Sensitization to inhalant and food allergens in Brazilian atopic children by <i>in vitro</i> total and specific IgE assay. Allergy Project - PROAL

What drives the allergic march?

Sensibilização a alérgenos inalantes e alimentares em crianças brasileiras atópicas, pela determinação in vitro de IgE total e específica: Projeto Alergia (PROAL)

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