Natural Cuban zeolites for medical use and their histamine binding capacity

Selvam, T.; Schwieger, Wilhelm; Dathe, W.

doi:10.1180/claymin.2014.049.4.01

Cited by 21 publications

(36 citation statements)

References 45 publications

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“…The widely tested zeolite suitable for medical applications in vivo is the clinoptilolite tuff but the mordenite tuff was also studied by Selvam et al (2014) So far the word ‘zeolite’ has been used in the literature for different types of zeolites, tuffs, and clays. For example, both clinoptilolite and clay materials may be used for ion-exchange reactions.…”

Section: Chemical Properties and Biological Application Of Natural Zementioning

confidence: 99%

Critical Review on Zeolite Clinoptilolite Safety and Medical Applications in vivo

et al. 2018

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Unique and outstanding physical and chemical properties of zeolite materials make them extremely useful in a variety of applications including agronomy, ecology, manufacturing, and industrial processes. Recently, a more specific application of one naturally occurring zeolite material, clinoptilolite, has been widely studied in veterinary and human medicine. Due to a number of positive effects on health, including detoxification properties, the usage of clinoptilolite-based products in vivo has increased enormously. However, concerns have been raised in the public about the safety of clinoptilolite materials for in vivo applications. Here, we review the scientific literature on the health effects and safety in medical applications of different clinoptilolite-based materials and propose some comprehensive, scientifically-based hypotheses on possible biological mechanisms underlying the observed effects on the health and body homeostasis. We focus on the safety of the clinoptilolite material and the positive medical effects related to detoxification, immune response, and the general health status.

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Section: Chemical Properties and Biological Application Of Natural Zementioning

confidence: 99%

Critical Review on Zeolite Clinoptilolite Safety and Medical Applications in vivo

et al. 2018

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“…In healthy persons, dietary histamine can be rapidly detoxified by amine oxidases, whereas persons with low amine oxidase activity are at risk of histamine toxicity [32]. Histamine uptake by natural zeolites is one of therapeutic modalities for reducing histamine content in the intestinal tract [33]. High absorption capacity could also be shown using Symbio®detox in the present study.…”

Section: Discussionmentioning

confidence: 56%

Smectite for Medical Use and Their Toxin Binding Capacity

Müller¹,

Dobler²,

Schmidts³

et al. 2019

J Food Nutr Popul Health

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A detoxification product (Symbio®detox), containing diosmectite, boswellia and Commiphora resin was tested in terms of its adsorption behavior. We showed that it was able to adsorb large amounts of various toxins, including heavy metals, ammonium and histamine. At pH=2.0 is 9.5% of lead 98% of mercury and 8.8% zinc were adsorbed, while ammonium (2.5%) remained largely unaffected. At pH 6.5, we observed significantly increased adsorption for lead (60.4%), ammonium (7.2%) and histamine (91%); the adsorption of zinc (11.2%) was only slightly higher than at pH=2.0. By contrast, the adsorption of mercury (84.6%) was slightly lower under these conditions. The adsorption of toxic heavy metals including mercury and lead was greater than that of zinc. Thus, Symbio®detox may be used as a medical product because of its excellent binding capacity for toxins including heavy metals, ammonia and histamine. In addition, the product is not likely to result in deficiency of the essential mineral zinc. Finally, we did not detect adsorption of the pharmaceutically relevant ingredients Boswellia serrata resin and Commiphora molmol resin.

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“…However, the interactions of natural high-silica zeolites (such as clinoptilolite) with acidic aqueous media generally occur at low dissolution rates, as they are acid resistant [34]. The Al release from zeolites under acidic conditions was also investigated by Akkoca et al for Turkish natural zeolites [8] and by Selvam et al in Cuban natural zeolites [35]. The high Al release is determined by the easier hydrolysis of Al-O-Al than of Si-O-Si bonds under acidic conditions and the formation of complexes on the zeolite surface in the presence of Cl − [8].…”

Section: Concentration Of Major Elements In Simulated Gastric Fluid Amentioning

confidence: 99%

“…The relationship between PC1 and PC3 shows that the P concentration is not influenced by the zeolite to SGF ratio or by the exposure time. However, the concentrations of the other elements are slightly influenced by the exposure time, probably because in acidic solutions such as SGF (pH = 1.2), the released Na, K, Ca, and Mg ions from zeolites rapidly (in the first 30 min) reach an equilibrium after 5 h [35]. Additionally, the release of Si and Al ions occurs within the first 30 min and gradually increases up to 5 h, mainly due to the desilication and dealumination of the zeolite [35].…”

Section: Concentration Of Major Elements In Simulated Gastric Fluid Amentioning

confidence: 99%

Effects of Thermal Treatment on Natural Clinoptilolite-Rich Zeolite Behavior in Simulated Biological Fluids

et al. 2020

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This study presents the effect of thermal treatment (450, 500, 600, 750, and 800 °C) on a Romanian clinoptilolite-rich natural zeolite, along with the interaction of raw and thermally treated zeolites with simulated gastric fluid (SGF, pH = 1.20) at different zeolite to SGF ratios and exposure times. The zeolites were characterized using gravimetric analysis, X-ray fluorescence, powder X-ray diffraction (pXRD), and Fourier transform infrared (FT-IR) spectroscopy. The chemical composition of the zeolite subjected to thermal treatment did not change significantly with the increase of temperature. Structural changes were not detectable by pXRD and FT-IR analyses in the zeolites thermally treated up to 500 °C, while above 600 °C a gradual structural breakdown of zeolite was noticed. At high temperatures, the broad, low-intensity peaks in pXRD patterns indicated the partial amorphization of the crystalline structure. The pXRD and FT-IR analyses showed that the crystalline structure of zeolites remains unaffected after their exposure to SGF. The results revealed that the amounts of Fe, Na, Mg, K, Ca, Al, and Si released depends mainly on the zeolite to SGF ratio, and to a lower extent on the thermal treatment temperature, while the exposure time of 1 to 7 days does not have a significant impact on the elements released in SGF.

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Natural Cuban zeolites for medical use and their histamine binding capacity

Cited by 21 publications

References 45 publications

Critical Review on Zeolite Clinoptilolite Safety and Medical Applications in vivo

Critical Review on Zeolite Clinoptilolite Safety and Medical Applications in vivo

Smectite for Medical Use and Their Toxin Binding Capacity

Effects of Thermal Treatment on Natural Clinoptilolite-Rich Zeolite Behavior in Simulated Biological Fluids

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