Natural Estrogen Receptor Modulators and Their Heterologous Biosynthesis

Yang, Jiali; Wen, Li; Jiang, Yueming; Yang, Bao

doi:10.1016/j.tem.2018.11.002

Cited by 33 publications

(24 citation statements)

References 62 publications

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“…The studies have proven that PSO has the next pharmacological properties: antidepressant (Farahani et al, 2015), modulator of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) signaling pathway (Rana et al, 2014) and it is an potential estrogen receptor modulator (Yang et al, 2019). The main therapeutic properties of PSO and its mechanisms of action are summarized in Figure 3.…”

Section: Pharmacological Importance Of Psoralidin: In Vitro and In VImentioning

confidence: 99%

Pharmacological Activities of Psoralidin: A Comprehensive Review of the Molecular Mechanisms of Action

et al. 2020

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Analysis of the most relevant studies on the pharmacological properties and molecular mechanisms of psoralidin, a bioactive compound from the seeds of Cullen corylifolium (L.) Medik. confirmed its complex therapeutic potential. In the last years, the interest of the scientific community regarding psoralidin increased, especially after the discovery of its benefits in estrogen-related diseases and as a chemopreventive agent. Growing preclinical pieces of evidence indicate that psoralidin has anticancer, antiosteoporotic, anti-inflammatory, anti-vitiligo, antibacterial, antiviral, and antidepressant-like effects. Here, we provide a comprehensive and critical review of psoralidin on its bioavailability, pharmacological activities with focus on molecular mechanisms and cell signaling pathways. In this review, we conducted literature research on the PubMed database using the following keywords: "Psoralidin" or "therapeutic effects" or "biological activity" or "Cullen corylifolium" in order to identify relevant studies regarding PSO bioavailability and mechanisms of therapeutic effects in different diseases based on preclinical, experimental studies. In the light of psoralidin beneficial actions for human health, this paper gathers complete information on its pharmacotherapeutic effects and opens new natural therapeutic perspectives in chronic diseases.

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Section: Pharmacological Importance Of Psoralidin: In Vitro and In VImentioning

confidence: 99%

Pharmacological Activities of Psoralidin: A Comprehensive Review of the Molecular Mechanisms of Action

et al. 2020

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“…Sex-stratified analysis showed that the correlations urinary phytoestrogen metabolite concentrations and serum 25(OH)D level were stronger in women than in men. Phytoestrogens mainly acted by binding to the estrogen receptor (ER) which was expressed more in females than in males (13,54,55). Some behaviors such as taking oral contraceptives and wearing sunscreen, which were observed more in women than in men also contributed to the sex-specific difference in the relationship between phytoestrogens and the vitamin D level (56,57).…”

Section: Discussionmentioning

confidence: 99%

Urinary Phytoestrogen Metabolites Positively Correlate with Serum 25(OH)D Level Based on National Health and Nutrition Examination Survey 2009–2010

Chen

Jiang

et al. 2021

J Nutr Sci Vitaminol

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Studies showed that vitamin D (25-hydroxyvitamin D) level in the human blood circulation could be affected by exogenous estrogen exposure. This study aims to explore the relationships between urinary phytoestrogens metabolites and serum total 25(OH)D in general population, urinary phytoestrogens metabolites (daidzein, enterodiol, enterolactone, equol, genistein and o-desmethylangolensin). Totally 2,609 adults 6 y old from the 2009-2010 National Health and Nutrition Examination Surveys (NHANES) were recruited into the cross-sectional analyses and information including demographic, socioeconomic, examinations and laboratory test were collected. All analyses were performed using Stata13.0, one-way analysis of variance and multivariable regression were utilised according to data characteristics, respectively. It showed that age, race, education level, body mass index (BMI), and sampling season had significant effects on serum 25(OH)D level (all p,0.001). In the whole population, urinary enterodiol and equol were significantly positively associated with serum total 25(OH)D level (b50.86, 95%CI50.08-1.65, p,0.05; b51.68, 95%CI50.91-2.45, p,0.001). Equol was also found significantly positively correlated with total 25(OH)D in both female and male separately (b51.69, 95%CI50.51-2.87, p,0.05; b51.66, 95%CI50.63-2.69, p,0.05). Phytoestrogen concentrations in the urinary and 25(OH)D levels in the serum had proved a positive correlation in our study, which provide theoretical basis and reference for the dietary nutrient intake in the population.

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“…genistein can exert androgenic effects [53], which is not surprising as PhE are plant substances with accidental similarity to human hormones, so that their effects are a priori unpredictable. It was suggested that PhE are estrogen receptor modulators thus being different from estrogens [54]. It is questionable, however, whether such modulations, also called endocrinedisrupting [16,55], are favorable for soy consumers, especially at a young age.…”

Section: Phytoestrogens and Soy Productsmentioning

confidence: 99%

Scientific Papers and Patents on Substances with Unproven Effects. Part 2

Jargin

2020

DDF

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: Several examples are discussed in this review, where substances without proven effects were proposed for practical use within the scope of evidence-based medicines. The following is discussed here: generalizations of the hormesis concept and its use in support of homeopathy; phytoestrogens and soy products potentially having feminizing effects; glycosaminoglycans for the treatment of osteoarthritis and possibilities of their replacement by diet modifications; flavonoids recommended for the treatment of chronic venous insufficiency and varicose veins; acetylcysteine as a mucolytic agent and its questionable efficiency especially by an oral intake; stem cells and cell therapies. In conclusion, placebo therapies can be beneficial and ethically justifiable but it is not a sufficient reason to publish biased information. Importantly, placebo must be devoid of adverse effects, otherwise, it is named pseudo-placebo. Therapeutic methods with unproven effects should be tested in high-quality research shielded from the funding bias. Some issues discussed in this review are not entirely clear, and the arguments provided here can initiate a constructive discussion.

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Natural Estrogen Receptor Modulators and Their Heterologous Biosynthesis

Cited by 33 publications

References 62 publications

Pharmacological Activities of Psoralidin: A Comprehensive Review of the Molecular Mechanisms of Action

Pharmacological Activities of Psoralidin: A Comprehensive Review of the Molecular Mechanisms of Action

Urinary Phytoestrogen Metabolites Positively Correlate with Serum 25(OH)D Level Based on National Health and Nutrition Examination Survey 2009–2010

Scientific Papers and Patents on Substances with Unproven Effects. Part 2

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