Natural Flavonoids as Superior Reagents for Separation of Clinically Important Zr Radionuclides

Abstract

This paper exploits the affinity of bio-flavonoid hesperidin, isolated from orangepeel, towards the separation of clinically important 88Zr radionuclide from high energy proton bombarded yttrium target. The extraction of Zr with hesperidin was studied by solid-liquid extraction (SLX) technique over a wide pH range. The advantage of hesperidin is that it acts as separating agent as well as free-radical scavenging agent upon injection of the radionuclidehesperidin complex in-vivo. The stability of isolated hesperidin under strong radiation field was also studied. The selectivity of the bio-flavonoid towards 88Zr was maximum at pH=4 where in >78% Zr was extracted with <1% contamination from bulk yttrium target.

Synergistic Aqueous Biphasic Separation of No‐Carrier‐Added 71,72As from a Gallium Oxide Target Using Green Tea Polyphenols

“…Earlier we have successfully used nature resourced chemicals (NRC) in various radiochemical separations. Few examples of NRCs are: hesperidin obtained from orange peel, [9] potato peels, [10,11] conarachin and arachin extracted from groundnut, [12,13] piperine extracted from black pepper, [14] seed protein from Bakul tree, [15] Mung beans, [16] albumin from egg, [17] etc., all of which were successfully applied to develop radiochemical separation techniques. Presence of hydroxyl groups in the structure of catechins helps them to scavenge reactive oxygen species such as superoxide radicals, singlet oxygen, hydroxyl radicals, nitric oxide, nitrogen dioxide, and peroxynitrite, all of which play important roles in free radical induced carcinogenesis.…”