Natural Flavonoids in StAR Gene Expression and Testosterone Biosynthesis in Leydig Cell Aging

Wang, Xing Jia

doi:10.5772/16574

Cited by 3 publications

(2 citation statements)

References 184 publications

(175 reference statements)

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“…Other authors have reported that quercetin increases StAR mRNA levels, StAR promoter activity, and steroid hormone production by MA-10 Leydig cells [91]. According to Wang, StAR expression and steroidogenesis in Leydig cells are also enhanced by blocking sex-determining region Y-box 2 (Sox2) signaling in response to quercetin [92].…”

Section: Antioxidants and Steroidogenic Function Of Leydig Cellsmentioning

confidence: 99%

Black Chokeberry (Aronia melanocarpa) Juice Supplementation Improves Oxidative Stress and Aging Markers in Testis of Aged Rats

Daskalova,

Pencheva,

Denev

2024

CIMB

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Spermatogenesis is a process that continues until the end of an individual’s life, although with reduced activity with advancing age. Inflammation, oxidation, and apoptosis are events considered as predictors of pathogenesis and the development of age-related diseases observed in aged testes. The use of natural compounds with antioxidant and anti-inflammatory properties has a beneficial effect on the inflammatory and oxidative status of the aged testis. The aim of this study was to determine the effect of supplementation with antioxidant-rich black chokeberry (Aronia melanocarpa) juice on several markers of oxidative stress and aging in rat testis. In total, 24 male Wistar rats were divided into three experimental groups: young controls aged 2 months, old controls aged 27 months, and 27-month-old rats supplemented with black chokeberry juice at a dose of 10 mL/kg for 3 months. A. melanocarpa juice supplementation led to reduced oxidative stress, manifested by increased immunoexpression of nNOS, eNOS, and MAS1 in the seminiferous tubules and in the Leydig cells. The morphometrically determined tubule structure data showed no significant differences between the three groups. However, the intensity of the immunoreaction for TRK-C and NT3 in Leydig cells was demonstrably higher in the supplemented old animals compared with the old controls. There was a significantly higher number of blood vessels around the seminiferous tubules in the supplemented animals compared to the old controls. These data indicate that supplementation with A. melanocarpa juice slows down aging processes in the testis and preserves the functional activity of Leydig cells.

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Section: Antioxidants and Steroidogenic Function Of Leydig Cellsmentioning

confidence: 99%

Black Chokeberry (Aronia melanocarpa) Juice Supplementation Improves Oxidative Stress and Aging Markers in Testis of Aged Rats

Daskalova,

Pencheva,

Denev

2024

CIMB

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“…Research shows thatthere are severalrolesplayed by the StARprotein as a biomarker of steroidogenesisactivity, one of whichisthat the inhibition of thisproteinis capable of causing disruption of the hypothalamus-pituitarytestis axis whichsubsequently impacts LH secretion (5,6) .…”

Section: Introductionmentioning

confidence: 99%

Steroidogenesis Mechanism, Disruption Factor, Gene Function, and Role in Male Fertility : A Mini Review

I Gede Widhiantara,

Anak Agung Ayu Putri Permatasari,

I Wayan Rosiana

et al. 2021

Indian Journal of Forensic Medicine & Toxicology

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Male fertility can be defined as the ability of the male reproductive system to impregnate a woman, while infertility is the condition of a married couple who have been married for one year or more and have had sexual intercourse regularly or without using contraception but do not have a pregnancy or offspring. About 10% of married couples experience infertility. The main organ of male reproduction is the testes because in the testes the process of forming spermatozoa and the hormone testosterone occurs. The hormone testosterone plays a direct role in the continuity of spermatogenesis. Testosterone is produced through a series of steroidogenesis mechanisms in testicular Leydig cells. Several factors influence the course of steroidogenesis such as Leydig cells, steroidogenesis proteins, related genes to the influence of free radicals. These factors are closely related to diet and lifestyle. This study is important to understand in efforts to prevent infertility in men.

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Nano Spirulina platensis countered cisplatin-induced repro-toxicity by reversing the expression of altered steroid hormones and downregulation of the StAR gene

Khalil,

Rady,

Darwish

et al. 2024

Naunyn-Schmiedeberg's Arch Pharmacol

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Cisplatin is a commonly utilized chemotherapy medication for treating different sarcomas and carcinomas. Its ability interferes with cancer cells’ DNA repair pathways and postpones unfavorable outcomes in cancer patients. The current investigation’s goal was to ascertain if nano Spirulina platensis (NSP) might shield rat testicles from cisplatin damage by assessing the expression of the StAR and SOD genes, sex hormones, 17ß-hydroxysteroid dehydrogenase(17ß-HSD), sperm profile picture, oxidative condition of testes, testicular histology, and DNA damage. Four equal and random groups of 28 adult male Wistar rats were created; the control group was given saline for 8 weeks. An extraction of NSP at a concentration of 2500 mg/kg body weight was administered orally for 8 weeks to the NSP group. For the first 4 weeks, the cisplatin group was intraperitoneally injected with 2 mg/kg/body weight of cisplatin, and for the next 4 weeks, they were given a dosage of 4 mg/kg/body weight. The cisplatin + NSP group was given both NSP and cisplatin. The results of the experiment showed that intake of NSP and cisplatin improved sperm profile; re-established the balance of oxidizing agents and antioxidant state; enhanced testicular histology; promoted the histometric parameters of seminiferous tubules including epithelial height, their diameter, and Johnsen’s score, decreasing DNA breakage in testicular tissue; increased testosterone level; decreased 17ß-HSD concentration; and upregulated both the StAR and SOD gene expression in testicles compared to rats exposed to cisplatin alone. These results demonstrate that NSP is a promising agent for improving cisplatin-induced testicular injury and infertility.

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Natural Flavonoids in StAR Gene Expression and Testosterone Biosynthesis in Leydig Cell Aging

Cited by 3 publications

References 184 publications

Black Chokeberry (Aronia melanocarpa) Juice Supplementation Improves Oxidative Stress and Aging Markers in Testis of Aged Rats

Black Chokeberry (Aronia melanocarpa) Juice Supplementation Improves Oxidative Stress and Aging Markers in Testis of Aged Rats

Steroidogenesis Mechanism, Disruption Factor, Gene Function, and Role in Male Fertility : A Mini Review

Nano Spirulina platensis countered cisplatin-induced repro-toxicity by reversing the expression of altered steroid hormones and downregulation of the StAR gene

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