Natural History and Progression of Craniofacial Fibrous Dysplasia: A Retrospective Evaluation of 114 Patients From Massachusetts General Hospital

Sweeney, Kristin G.; Kaban, Leonard B.

doi:10.1016/j.joms.2020.05.036

Cited by 14 publications

(24 citation statements)

References 47 publications

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“…FD represents 7% of all benign bone tumors and includes the facial bones in approximately 10%-27% of MFD patients [1][2][3][4]. Chen et al state that MFD affects the maxilla more regularly than the mandible [8].…”

Section: Discussionmentioning

confidence: 99%

“…Conservative surgical management implicates surgical excision of the poorly mineralized bone followed by a modeling osteoplasty through an intraoral approach which can potentially help Case Reports in Dentistry with the histological confirmation of the diagnosis [9,10,12,13]. The surgical treatment should take into consideration the age of the patient [4,9]. The recurrence of fibrous dysplasia is reported in relation to puberty or skeletal maturation; however, its evolution is constant into adulthood [1,4,9].…”

Section: Discussionmentioning

confidence: 99%

“…Fibrous dysplasia (FD) is a benign intraosseous tumor-like process, where the medullary bone is substituted by fibrous connective tissue leading to undeveloped and inadequately calcified bone [1][2][3][4]. FD involves an inequity among osteoblastic and osteoclastic activities triggered by a genetic mutation in the stimulatory G protein (GSα) [5].…”

Section: Introductionmentioning

confidence: 99%

“…FD commonly develops in the first or second decades of life, affects women more than men with a ratio of 2 : 1, and is usually asymptomatic with very low evolution [1,2]. FD occurs either as a monostotic form affecting a single bone or as a polyostotic form spreading into several bones [1][2][3][4]. Monostotic fibrous dysplasia (MFD) is around 10 times more common than polyostotic fibrous dysplasia (PFD) and is frequently unilateral [3,4].…”

Section: Introductionmentioning

confidence: 99%

“…FD occurs either as a monostotic form affecting a single bone or as a polyostotic form spreading into several bones [1][2][3][4]. Monostotic fibrous dysplasia (MFD) is around 10 times more common than polyostotic fibrous dysplasia (PFD) and is frequently unilateral [3,4]. The lack of stable bone matrix formation can manifest in a multitude of ways, involving facial distortion and asymmetry [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

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Monostotic Fibrous Dysplasia of the Mandible in a 9-Year-Old Male Patient Treated with a Conservative Surgical Treatment: A Case Report and 15-Year Follow-Up

Berbéri

Aoun

Khalaf

et al. 2021

Case Reports in Dentistry

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Fibrous dysplasia is a developmental disorder of the bone that originates from a genetic defect disturbing the osteogenesis leading to the replacement of normal bone with the excess proliferation of fibrous tissue. It can be associated with hyperpigmentation of the skin and endocrine disorders. Fibrous dysplasia can manifest in a monostotic form affecting one bone or in a polyostotic form involving several bones. Approximately 30% of monostotic forms are observed in the maxilla and the mandible. It frequently appears in the posterior region and is usually unilateral. It is found in teenagers and could become static after adulthood. Patients can present with swelling, facial asymmetry, pain, or numbness on the affected side. Treatment modalities vary between conservative surgical treatment, radical surgical approach, and medical treatment based on bisphosphonates. Here, we present a case of a monostotic form of fibrous dysplasia affecting the posterior left region of the mandible in a 9-year-old male complaining of gradually increased swelling on the left mandibular side of one-year duration. The diagnosis of fibrous dysplasia is established based on clinical, radiographical, and histopathological features. Conservative surgery is implemented with surgical shaving and reencountering of the bone excess to reduce the facial asymmetry. Recurrence is reported 10 years later and is also treated with a localized osteoplasty and remodeling of the bone contours. Five years later, the lesion remains stable. In conclusion, a conservative approach should be adopted as the first line of treatment for young patients suffering from monostotic fibrous dysplasia.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Monostotic Fibrous Dysplasia of the Mandible in a 9-Year-Old Male Patient Treated with a Conservative Surgical Treatment: A Case Report and 15-Year Follow-Up

Berbéri

Aoun

Khalaf

et al. 2021

Case Reports in Dentistry

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Clinicopathological and genetic study of a rare occurrence: Malignant transformation of fibrous dysplasia of the jaws

Shi

Zhang

et al. 2022

Molec Gen & Gen Med

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Die neue WHO-Klassifikation der Kiefertumoren

Haefliger

Baumhoer

2023

Pathologie

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ZusammenfassungOdontogene Tumoren und Kiefertumoren umfassen ein breites Spektrum an Läsionen, darunter Neoplasien, hamartomatöse Veränderungen und Entwicklungsstörungen. Seit Anfang 2022 ist eine Beta-Version der 5. Auflage der WHO-Klassifikation für Kopf-Hals-Tumoren online verfügbar, die voraussichtlich Mitte 2023 auch als Printversion erscheinen wird. Konzeptionell hat sich im Vergleich zur 4. Auflage nicht viel verändert. Die Reihenfolge der Läsionen ist stringenter nach Dignität geordnet und die gleichen Tumoren werden nicht mehr in verschiedenen Kapiteln lokalisationsabhängig mehrfach beschrieben. Diagnostische Kriterien werden neu in „essential“ und „desirable“ zusammengefasst. Zusätzlich zu den klinischen Aspekten wird nun auch die Bildgebung miteinbezogen und die Klassifikation damit interdisziplinär. Vereinzelt sind auch neue Läsionen erstmals aufgeführt. Dieser Artikel gibt einen Überblick über die Neuerungen der neuen Klassifikation mit einem speziellen Fokus auf die Einteilung der fibroossären Kieferläsionen.

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Natural History and Progression of Craniofacial Fibrous Dysplasia: A Retrospective Evaluation of 114 Patients From Massachusetts General Hospital

Cited by 14 publications

References 47 publications

Monostotic Fibrous Dysplasia of the Mandible in a 9-Year-Old Male Patient Treated with a Conservative Surgical Treatment: A Case Report and 15-Year Follow-Up

Monostotic Fibrous Dysplasia of the Mandible in a 9-Year-Old Male Patient Treated with a Conservative Surgical Treatment: A Case Report and 15-Year Follow-Up

Clinicopathological and genetic study of a rare occurrence: Malignant transformation of fibrous dysplasia of the jaws

Die neue WHO-Klassifikation der Kiefertumoren

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