Natural history of celiac disease autoimmunity in a USA cohort followed since 1974

Catassi, Carlo; Kryszak, Debby; Bhatti, Bushra; Sturgeon, Craig; Helzlsouer, Kathy J.; Clipp, Sandra; Gelfond, Daniel; Puppa, Elaine Leonard; Sferruzza, Anthony; Fasano, Alessio

doi:10.3109/07853890.2010.514285

Cited by 342 publications

(273 citation statements)

References 31 publications

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“…Several studies in adults have identified individuals who were initially serologically negative but later developed a positive antibody. 7 In addition, our patient was under triple immunosuppressive treatment for renal transplant, which may have impaired the ability to produce antibodies. In addition to negative serology, there was no apparent micronutrient deficiency either.…”

Section: Discussionmentioning

confidence: 99%

Unintentional Weight Loss in a Renal Transplant Recipient: Do Not Overlook Coeliac Disease

Solak

Gaipov²,

Bıyık

et al. 2013

Exp Clin Transplant

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Unintentional weight loss in a renal transplant recipient is an important condition, requiring diagnostic search within the framework of malignancy and opportunistic infections. To the best of our knowledge, there are no data in the literature reporting underlying coeliac disease as the cause of significant weight loss after renal transplant. We report a 32-year-old woman, who complained of significant weight loss during the 3.5 years posttransplant. Diagnostic work-up revealed coeliac disease, and a gluten-free diet stabilized her weight loss. Considering the high frequency of coeliac disease, this should be kept in the differential diagnosis of renal transplant recipients presented with weight loss and other suggestive features.

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Section: Discussionmentioning

confidence: 99%

Unintentional Weight Loss in a Renal Transplant Recipient: Do Not Overlook Coeliac Disease

Solak

Gaipov²,

Bıyık

et al. 2013

Exp Clin Transplant

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“…Among these, the common susceptibility loci of HLA and other immune system-related genes, 3 permeability changes in the small-bowel mucosa, 4 and association with wheat consumption 4,5 are prominent. Both diseases are increasing in most regions of the world, 6,7 as are several other autoimmune diseases, but the actual cause of the disease remains unknown. However, several recent studies have highlighted the role of environmental and social changes that have taken place over the last several decades.…”

Section: Introductionmentioning

confidence: 99%

Celiac disease in patients with type 1 diabetes: a condition with distinct changes in intestinal immunity?

et al. 2011

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Two common chronic childhood diseases-celiac disease (CD) and type 1 diabetes (T1D)-result from complex pathological mechanisms where genetic susceptibility, environmental exposure, alterations in intestinal permeability and immune responses play central roles. In this study, we investigated whether these characteristics were universal for CD independently of T1D association. For this purpose, we studied 36 children with normal small-bowel mucosa and 26 children with active CD, including 12 patients with T1D. In samples from the small-bowel mucosa, we detected the lowest expression of tight junction protein 1 (TJP1) mRNA in CD patients with T1D, indicating an increase in intestinal permeability. Furthermore, these samples displayed the highest expression of forkhead box P3 (FoxP3) mRNA, a marker for regulatory T cells, as compared with other patient groups. At the same time, serum levels of IgA antibodies specific for the CD-related antigens deamidated gliadin and tissue transglutaminase (tTG) were the highest in CD patients with T1D. In contrast, no significant differences were found in IgA or IgG antibodies specific for bovine beta-lactoglobulin or Bifidobacterium adolescentis DSM 20083-derived proteins. There were also no differences in the transamidating activity of serum autoantibodies between patients and control individuals. Our results show that patients with T1D and newly detected CD exhibit severely altered intestinal permeability, strong local immune activation and increased immunoregulatory mechanisms in the small bowel. Further study is required to determine whether these extreme changes in this CD subgroup are due to some specific environmental factors (virus infections), unknown genetic effects or autoimmune reactions to antigenic targets in intracellular tight junctions. INTRODUCTIONWith an approximate prevalence of 1.0% in Western countries, celiac disease (CD) is one of the most common lifelong chronic disorders. 1 CD and type 1 diabetes (T1D) form a significant sector of childhood diseases with high rate of co-occurrence. 2 Both diseases are autoimmune in origin and develop as a result of complex pathological mechanisms, involving several common genetic, environmental and immunological factors. Among these, the common susceptibility loci of HLA and other immune system-related genes, 3 permeability changes in the small-bowel mucosa, 4 and association with wheat consumption 4,5 are prominent. Both diseases are increasing in most regions of the world, 6,7 as are several other autoimmune diseases, but the actual cause of the disease remains unknown. However, several recent studies have highlighted the role of environmental and social changes that have taken place over the last several decades. 8,9 The central event in the pathogenesis of CD is damage to the small intestinal mucosa that occurs after ingestion of gluten or related prolamins in genetically susceptible individuals. During this process, several morphological and immunological alterations have been demonstrated in the small-bowel mucos...

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“…Необходимость анализа несколь-ких фрагментов слизистой кишки вытекает из мозаичности явлений атрофии при Ц. Отсутствие правильной ориента-ции гистологического материала (необходимо оценивать фрагменты вдоль длины ворсинки) может приводить к ложноположительным результатам за счет получения феномена «псевдоукорочения» ворсинок [1,3,4,9,10].…”

Section: ошибка 2 взятие недостаточного количества и отсут-ствие праunclassified

Difficulties in establishment of celiac syndrome diagnosis

Осипенко¹,

Шрайнер²

2016

Med. sov.

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В статье описаны сложности диагностики целиакии, указаны причины диагностических ошибок в разных клинических примерах. Это помогает восприятию конкретных программ диагностики и подбору схожих нозологических форм, между которыми следует проводить дифференциальную диагностику.Ключевые слова: целиакия, диагностика, ошибки. M.F. OSIPENKO, MD, Prof., E.V. SHREINER DIFFICULTIES IN ESTABLISHMENT OF CELIAC SYNDROME DIAGNOSISThe article describes difficulties of the celiac syndrome diagnostics, causes of diagnostic errors in various clinical examples are specified. This helps to perceive certain diagnostics programs and to select similar nosologic entities between which the differential diagnostics should be conducted.

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Natural history of celiac disease autoimmunity in a USA cohort followed since 1974

Abstract: During a 15-year period CD prevalence increased 2-fold in the CLUE cohort and 5-fold overall in the US since 1974. The CLUE study demonstrated that this increase was due to an increasing number of subjects that lost the immunological tolerance to gluten in their adulthood.

Cited by 342 publications

References 31 publications

Unintentional Weight Loss in a Renal Transplant Recipient: Do Not Overlook Coeliac Disease

Unintentional Weight Loss in a Renal Transplant Recipient: Do Not Overlook Coeliac Disease

Celiac disease in patients with type 1 diabetes: a condition with distinct changes in intestinal immunity?

Difficulties in establishment of celiac syndrome diagnosis

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