Natural History of Subclinical Neovascularization in Nonexudative Age-Related Macular Degeneration Using Swept-Source OCT Angiography

Dias, João Rafael de Oliveira; Zhang, Qinqin; Garcia, José Maurício Botto de Barros; Zheng, Fang; Motulsky, Elie; Roisman, Luiz; Miller, Andrew; Chen, Chieh Li; Kubach, Sophie; Sisternes, Luís de; Durbin, Mary K; Feuer, William J.; Wang, Ke; Gregori, Giovanni; Rosenfeld, Philip J.

doi:10.1016/j.ophtha.2017.08.030

Cited by 180 publications

(162 citation statements)

References 30 publications

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“…With newer advancements such as swept-source OCTA, the speed and resolution of image acquisition is greatly advanced, rendering highly detailed images of the retinal and choroidal vasculature. Prior studies have shown novel and useful applications of this technology to detect choroidal neovascularization, neovascular growth in proliferative diabetic retinopathy, or analyze in detail choroidal architecture 13, 14, 15…”

Section: Discussionmentioning

confidence: 99%

Familial retinal arteriolar tortuosity and quantification of vascular tortuosity using swept-source optical coherence tomography angiography

Saraf

Tyring

Chen

et al. 2019

American Journal of Ophthalmology Case Reports

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PurposeFamilial retinal arteriolar tortuosity (FRAT) is a rare autosomal dominant disorder that is characterized by tortuosity of the second and higher order retinal arterioles. We implement swept-source optical coherence tomography angiography (SS-OCTA) to quantify vessel tortuosity in patients with FRAT. We hypothesize that patients with FRAT will have higher retinal arteriole tortuosity when compared to controls.MethodsPatients were scanned with a SS-OCTA device (Plex Elite 9000, Carl Zeiss Meditec, Dublin, CA). Images of a 12 × 12 mm2 area centered on the fovea were processed, and retinal vessels >23.5 μm in diameter were identified. An automatic tortuosity measurement program written in MATLAB was used to assess vessel tortuosity. Branch points in the vessels were detected and used to separate the vasculature into individual segments. The tortuosity was measured by calculating the arc-chord ratio of each vessel segment, where a minimum value of 1 indicated a straight vessel and higher values corresponded to increasing tortuosity.ResultsTwo patients (4 eyes) with a known history of FRAT and six controls (12 eyes) were enrolled in the study. The mean tortuosity of all vessel segments (MTVS) in scans of FRAT eyes was on average 1.1244 [range: 1.1044–1.1438] while for control eyes it was 1.0818 [range: 1.0746–1.0872]. Average MTVS of FRAT eyes was significantly higher compared to control eyes (p = 0.03).Conclusions and ImportanceOur results are consistent with the hypothesis that patients with FRAT have higher objective measurements of tortuosity compared to controls. Broader applications of this method may be of benefit in other retinal diseases with changes in retinal vessel configuration.

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Section: Discussionmentioning

confidence: 99%

Familial retinal arteriolar tortuosity and quantification of vascular tortuosity using swept-source optical coherence tomography angiography

Saraf

Tyring

Chen

et al. 2019

American Journal of Ophthalmology Case Reports

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“…Lacking the confounding effect of leakage, OCTA permits detailed visualization of the intricate configuration of neovascular membranes in patients with nAMD and their evolution in response to anti-VEGF treatment [45] (Figure 5). In addition, OCTA is able to reveal a perfused vascular network in either subclinical CNV in its nonexudative stage [46] and advanced cases of overt nAMD with fibrotic scars and history of prior treatment with anti-VEGF therapies [47].…”

Section: Oct Angiographymentioning

confidence: 99%

Hyperreflective material as a biomarker in neovascular age-related macular degeneration

Casalino

Scialdone

Bandello

et al. 2020

Expert Review of Ophthalmology

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“…; de Oliveira Dias et al. ). However, it is important to pay attention to frequent presence of attenuation artefacts (for example due to presence of drusen) and projection artefacts from superficial vessels, when evaluating CC images obtained with OCT‐A (Cole et al.…”

Section: Introductionmentioning

confidence: 99%

Quantitative choriocapillaris evaluation in intermediate age‐related macular degeneration by swept‐source optical coherence tomography angiography

Vujosevic

Toma

Muraca

et al. 2019

Acta Ophthalmologica

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Purpose: To investigate choriocapillaris (CC) perfusion, by evaluating flow voids (FV), in eyes with intermediate age-related macular degeneration (iAMD) using swept-source optical coherence tomography angiography (SS-OCT-A). Methods: Patients with bilateral or unilateral iAMD and normal controls underwent SS-OCT and OCT-A examination. Choriocapillaris (CC) FVs were quantitatively assessed on OCT-A images using MATLAB (version 2017b; MathWorks, Natick, MA, USA), after a preprocessing aimed at compensating for CC attenuation artefacts. Three different thresholds [1 standard deviation (SD), 1.25 SD and 1.5 SD] were applied. Final FV percentage (FV%) was calculated as the ratio between area with absent flow and total scanned area. Results: Of 41 patients with iAMD and 16 normal subjects enrolled in the study, 39 eyes (39 patients) with iAMD and all 16 normal eyes (16 control subjects) were included in the final analysis. Mean FV% (1 SD) was 13.45 AE 0.66 in controls, 14.19 AE 1.23 in bilateral iAMD and 14.21 AE 0.99 in unilateral iAMD (p = 0.03, for difference between controls and bilateral iAMD). Mean FV% (1.25 SD) was 6.55 AE 0.65 in controls, 7.33 AE 1.4 in bilateral iAMD and 7.06 AE 1.4 in unilateral iAMD (p = 0.048, for difference between controls and bilateral iAMD). Mean FV% (1.5 SD) was 2.71 AE 0.82 in controls, 2.55 AE 1.12 in bilateral iAMD and 3.25 AE 1.17 in unilateral iAMD (p = 0.038, for difference between bilateral and unilateral iAMD). Conclusion: A significantly higher FV% was found in patients with iAMD versus controls. A higher trend in FV% was found in unilateral iAMD (with neovascular AMD in the fellow eye) versus bilateral iAMD, when applying the lowest threshold. Further, larger and longitudinal studies are needed to confirm this data.

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Natural History of Subclinical Neovascularization in Nonexudative Age-Related Macular Degeneration Using Swept-Source OCT Angiography

Cited by 180 publications

References 30 publications

Familial retinal arteriolar tortuosity and quantification of vascular tortuosity using swept-source optical coherence tomography angiography

Familial retinal arteriolar tortuosity and quantification of vascular tortuosity using swept-source optical coherence tomography angiography

Hyperreflective material as a biomarker in neovascular age-related macular degeneration

Quantitative choriocapillaris evaluation in intermediate age‐related macular degeneration by swept‐source optical coherence tomography angiography

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