Natural hydrogel dressings in wound care: Design, advances, and perspectives

A Double Network Composite Hydrogel with Self-Regulating Cu2+/Luteolin Release and Mechanical Modulation for Enhanced Wound Healing

“…Under acidic conditions, GS completely degraded in 20 days, while GSC degraded by only 60%. The introduction of Cu 2+ decelerated the rapid degradation of GS, contributing to a more aligned wound healing process (Figure g) …”

“…The introduction of Cu 2+ decelerated the rapid degradation of GS, contributing to a more aligned wound healing process (Figure 3g). 48 The release kinetics of bioactive components from the composite hydrogel play a crucial role in the wound healing process. Hence, we examined the drug release characteristics under conditions of both low pH and elevated levels of ROS (Figure 3h).…”

Recent Advances in the Degradability and Applications of Tissue Adhesives Based on Biodegradable Polymers

“…Due to their biodegradability and biocompatibility, hyaluronic acid-based tissue adhesives have been widely used in various biomedical fields. The most basic application of hyaluronic acid-based tissue adhesives is wound closure and hemostasis [8,95]. These applications require hyaluronic acid-based tissue adhesives to exhibit a strong adhesive performance.…”

Integrating Cellulose Microfibrils and Ellagitannins from Rambutan Peel with Gelatin for Production of Synergistic Biobased Hydrogels

“…27,28 Hydrogels derived from nature-inspired materials such as biopolymers have good biocompatibility that prevents acute inflammatory reactions, excellent moisture retention, microstructure similar to the extracellular matrix (ECM), and resemble living tissue, thus addressing limitations of synthetic and traditional wound dressing materials. 29,30 The study investigates the influence of ellagitannin on the properties of cellulose−gelatin composite hydrogels. Combining both abundant biopolymers does not require traditional chemical cross-linking based on toxic small molecules, such as glutaraldehyde, glyoxal, or formaldehyde.…”

“…To the best of our knowledge, the preparation of ellagitannin-functionalized hydrogels, especially in combination with cellulose microfibrils, has not been reported. Apart from their function as cross-linkers, ellagitannins also have distinctive antioxidant and antimicrobial properties, with potential interest in medical applications. , Hydrogels derived from nature-inspired materials such as biopolymers have good biocompatibility that prevents acute inflammatory reactions, excellent moisture retention, microstructure similar to the extracellular matrix (ECM), and resemble living tissue, thus addressing limitations of synthetic and traditional wound dressing materials. , …”