Natural Killer Cells and Other Effector Cells, and Their Roles in Resistance against Cancer

Herberman, Ronald B.

doi:10.1007/978-1-4684-4508-4_9

Cited by 7 publications

(6 citation statements)

References 159 publications

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“…The mechanism of the adverse effect of blood transfusion remains unclear, but there are many experimental and clinical reports that indicate nonspecific immunosuppression mediated by increased suppressor T cell activity [14], decreased T4/T8 (helper/ suppressor) lymphocyte ratios [15], and decreased natural killer cell activity [16,17] after blood transfusion. Possibly, the immunosuppressive effect of blood transfusion plays a large role on recurrence, especially in the early stages of the malignant tumor during the period when the host's immune system is functioning normally.…”

Section: Discussionmentioning

confidence: 99%

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Perioperative Blood Transfusion as a Prognostic Indicator in Patients with Hepatocellular Carcinoma

et al. 1999

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We studied the relation of perioperative blood transfusion and the outcomes in 175 patients with hepatocellular carcinoma (HCC) who underwent hepatic resection from 1986 to 1994 in our hospital. Hepatectomy was performed in 23 (13.1%) patients with and 152 (86. 9%) without blood transfusions. The cumulative cancer-free survival rates for patients who had received blood transfusion was significantly lower than that for patients who had not received blood transfusions (p = 0.003). Further examinations revealed a significant difference in cancer-free survival rates for stage I-II patients (n = 75) of HCC (p = 0.02) but not for stage III-IV patients (n = 56) (p = 0.06). Cox regression analysis for recurrence revealed that blood transfusion was the most significant prognostic indicator (p = 0.001) for recurrence in stage I-II patients but not in stage III-IV patients (p = 0.99). These results suggest that a perioperative blood transfusion may be a significant prognostic indicator for patients with HCC who had underwent hepatectomy, especially in stage I-II patients of HCC.

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Section: Discussionmentioning

confidence: 99%

“…Many experimental and clinical studies have shown that blood transfusions possibly due to modulation of immune function have an adverse effect on postoperative outcome after surgery for malignant neoplasms [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17].…”

mentioning

confidence: 99%

Perioperative Blood Transfusion as a Prognostic Indicator in Patients with Hepatocellular Carcinoma

et al. 1999

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“…LC 9018 (250 gg/mouse) was injected s.c. into the left inguinal region of the mice (10 mice/group) and the left inguinal lymph node cells were collected on days 1, 3, 5, 7 and 10. The lymph node cells were examined for NK cell activity as described by Herberman [ 11 ]. In brief, target cells in HBSS were labeled for 1 h at 37 ~ with 100/~Ci of Na~ 1 CrO 4 and the cells were washed three times with HBSS to remove unbound radiolabel.…”

Section: Methodsmentioning

confidence: 99%

The role of lymph node cells in the inhibition of metastasis by subcutaneous injection of Lactobacillus casei in mice

Matsuzaki

Yokokura

Mutai

1988

Med Microbiol Immunol

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The role of lymph node cells in the inhibition of metastasis of B16-BL6, a highly metastatic variant of B16 melanoma, by Lactobacillus casei YIT9018 (LC 9018) in C57BL/6 mice was determined. Subcutaneous (s.c.) injection of LC 9018 into the left inguinal or the left axillary region inhibited both axillary lymph node and lung metastasis of B16-BL6 after surgical excision of the tumors resulting from inoculation into the left front footpad of the mice. There was, however, little inhibition of the metastasis when LC 9018 was given in the inguinal or axillary region opposite the tumor inoculation. The s.c. injection of LC 9018 into the left inguinal region also augmented not only the cytolytic activity of the left inguinal lymph node cells but also the left axillary lymph node cells against B16-BL6 in vitro. However, the antimetastatic effect of LC 9018 was decreased when LC 9018 was injected s.c. into mice in which the left inguinal lymph nodes had been resected. Furthermore, natural killer cell activity of the left inguinal lymph node cells from mice injected s.c. with LC 9018 was augmented. These results suggest that the lymph node cells activated by the s.c. injection of LC 9018 played an important role in the inhibition of the metastasis and that the treatment with LC 9018 augmented the host immune response.

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“…Perioperative allogeneic blood transfusion may play an important role in suppressing the host immune system, for example by decreasing natural killer cell activity (Hanna et al, 1980;Herberman, 1984) and/or increasing suppressor T-cell activity and inhibition of lymphocyte transformation, thereby diminishing specific and non-specific immune responses. These effects are possibly due to the cytological and immunological factors for tumor recurrence after blood transfusion allowing for progression of residual cancer and leading to a poor prognosis (Kaplan et al, 1984).…”

Section: Immunomodulation and Blood Transfusionmentioning

confidence: 99%

Major Hepatectomy without Allogeneic Blood Transfusion for Hepatocellular Carcinoma

Rui¹

2012

Hepatocellular Carcinoma - Clinical Research

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Natural Killer Cells and Other Effector Cells, and Their Roles in Resistance against Cancer

Cited by 7 publications

References 159 publications

Perioperative Blood Transfusion as a Prognostic Indicator in Patients with Hepatocellular Carcinoma

Perioperative Blood Transfusion as a Prognostic Indicator in Patients with Hepatocellular Carcinoma

The role of lymph node cells in the inhibition of metastasis by subcutaneous injection of Lactobacillus casei in mice

Major Hepatectomy without Allogeneic Blood Transfusion for Hepatocellular Carcinoma

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