Natural killer cells kill tumour cells at a given stage of differentiation

Gidlund, Magnus; Örn, Anders; Pattengale, Paul K.; Jansson, Mats; Wigzell, Hans; Nilsson, Kenneth

doi:10.1038/292848a0

Cited by 181 publications

(87 citation statements)

References 15 publications

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“…Our observations with fresh human leukaemia cells demonstrate that susceptibility to NK cell-mediated lysis of a given target is not a constant property, but can be readily changed by exposure of the leukaemia cells to ActD. Working with cell lines, both Gidlund et al (1981) and Clark et al (1981) showed that susceptibility to NK lysis decreased or increased, when they were treated with inducers of cell differentiation. Induction of differentiation in the fresh leukaemic cells studied in this report, is an unlikely explanation for the observed enhancement since 4 hours are enough for these leukaemias while days of exposure were used in the differentiation induction experiments.…”

Section: Cellsmentioning

confidence: 93%

Treatment of fresh human leukaemia cells with actinomycin D enhances their lysability by natural killer cells

Hw¹,

Erhardt²,

Riethmüller³

1983

Br J Cancer

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Section: Cellsmentioning

confidence: 93%

Treatment of fresh human leukaemia cells with actinomycin D enhances their lysability by natural killer cells

Hw¹,

Erhardt²,

Riethmüller³

1983

Br J Cancer

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“…This change was accompanied by a significant decrease in the susceptibility of the line to NK-mediated lysis. A correlation between the state of differentiation of-tumour cells and their resistance to NK lysis has also been observed by Gidlund et al (1980) in several models.…”

Section: Discussionmentioning

confidence: 69%

Variable susceptibility to NK activity of cloned cell lines derived from a primary rat rhabdomyosarcoma: Relationship to metastatic potential

Poupon¹,

Judde²,

Pot-Deprun³

et al. 1983

Br J Cancer

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Summary In vitro cloned lines derived from a primary nickel-induced rat rhabdomyosarcoma exhibited diverse levels of susceptibility to spontaneous NK activity. The presence of NK target structures was revealed by competition assays on all cloned cell lines, and the NK susceptibility of the tumour lines varied according to their osmotic fragility. Tumour cell lines derived from metastatic lung nodules presented similar NK susceptibilities to cells originating from the primary tumour. However, cloned cell lines differed in their capacity to form lung colonies after i.v. injection, and in their potential for invading lungs after s.c. primary tumour development. No correlation was found between lung colonization potential and NK resistance. Studies of the correlation between metastatic potential and NK sensitivity revealed that (1) all the NK resistant tumour cells were highly metastatic; (2) NK susceptible tumour cells could be either highly or weakly metastatic. Therefore, highly metastatic tumour cells could be either resistant or susceptible to NK lysis. We conclude that the property of resistance to NK contributes to a high metastatic potential. However, other properties could counterbalance and finally prevail over NK susceptibility thus enabling NK susceptible cell lines to be also highly metastatic.

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“…Immunoblots revealed a 70-to 72-kd COX-2-immunoreactive band (Gidlund et al, 1981) in tissue derived from the SD group, which was barely detectable in group C (Fig. 1C).…”

Section: Cyclooxygenase-2 Localizationmentioning

confidence: 99%

Cyclooxygenase-2 Expression Associated with Spreading Depression in a Primate Model

Yokota¹,

Inoue

Kuge³

et al. 2003

J Cereb Blood Flow Metab

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Summary:The authors previously provided evidence that spreading depression (SD) can be evoked in primates. Cyclooxygenase-2 (COX-2) expression has been found to increase in the rodent cortex undergoing SD, and the authors sought to determine whether this association exists in primate brain. In the present study, neuronal COX-2 expression was induced during SD in the primate cortex. The mean expression ratio of COX-2 messenger RNA in animals with SD was significantly higher than that measured in controls (1.69 vs. 0.5; P ‫ס‬ 0.02). Induction of COX-2 in these animals was also detected by human microarray analysis. Results show that, as in rodents, neuronal COX-2 is induced in the primate cortex in response to SD.

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Natural killer cells kill tumour cells at a given stage of differentiation

Cited by 181 publications

References 15 publications

Treatment of fresh human leukaemia cells with actinomycin D enhances their lysability by natural killer cells

Treatment of fresh human leukaemia cells with actinomycin D enhances their lysability by natural killer cells

Variable susceptibility to NK activity of cloned cell lines derived from a primary rat rhabdomyosarcoma: Relationship to metastatic potential

Cyclooxygenase-2 Expression Associated with Spreading Depression in a Primate Model

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