Natural Nitrogenous Sesquiterpenoids and Their Bioactivity: A Review

Chen, Deli; Wang, Bowen; Sun, Zhaocui; Yang, Jun‐Shan; Xu, Xudong; Ma, Guoxu

doi:10.3390/molecules25112485

Cited by 19 publications

(6 citation statements)

References 96 publications

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“…According to previous studies, flavonoids are important in promoting plant growth, especially root growth ( Khalid et al, 2019 ), and indoles are essential in the synthesis of plant growth hormones ( Baumann et al, 2017 ). In addition, sesquiterpenoids are effective in promoting plant growth and resistance to various adversities ( Chen et al, 2020a ). Accordingly, the shift of metabolic pathways mentioned above may contribute to promoted growth of cucumber in artificial cultivation substrates than in soils, which was observed during the experiment (data not provided).…”

Section: Discussionmentioning

confidence: 99%

Diversity Shifts in the Root Microbiome of Cucumber Under Different Plant Cultivation Substrates

Zhou

Gao

et al. 2022

Front. Microbiol.

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Application of plant artificial cultivation substrates lead to alteration of rhizosphere environment. Whether this alteration could lead to root microbiome variation was limitedly investigated. This work aims to determine the diversity shifts in the root microbiome of cucumber under different plant cultivation substrates and predict corresponding function of these different root bacterial microbiota. Cucumber root samples cultivated with two artificial cultivation substrates and greenhouse soils were prepared. Subsequently, high throughput sequencing and bioinformatics analysis were applicated to compare the root bacterial diversity of cucumber cultivated in different substrates and their corresponding function. In total, 311,039 sequences were obtained, and they were annotated to 42 operational taxonomic units (OTUs), belonging to 28 genera, 18 families, 12 orders, four classes, and three phyla. The α and β diversity of samples from the two cultivation substrates and greenhouse soils were significantly different. Only 2–3 bacterial species were found to be discrepancy between cucumber root samples from artificial cultivation substrates and from greenhouse soils. The relative abundance of genus Asticcacaulis, Methylophilus, Massilia, Dyella, and Devosia in samples of artificial cultivation substrates was significantly higher than that of soils, while the relative abundance of genus Phenylobacterium, Noviherbaspirillum, and Arenimonas was significantly lower than that of soils. Besides, compared to cucumber root bacterial community cultivated in soils, the abundance of synthetic pathways for flavonoids and flavonols, bile acids, indole alkaloids, lactose, and neolactose increased by 41.6-, 28.7-, 5.9-, and 5.5-fold, respectively, in the bacterial community of the substrate 1-cultivated roots, and the abundance of clavulanic acid, receptor interaction, sesquiterpenoid, bile acid, flavonoid and flavonol, indole alkaloid, lactose, and neolactose synthetic pathways increased by 42.3-, 32.4-, 32.4-, 13.9-, 10.3-, 6.3-, and 5.2-fold, respectively, in the bacterial community of the substrate two-cultivated roots. This paper verified the diversity shifts in the root microbiome of cucumber under different plant cultivation substrates. Besides, the corresponding function difference of these different root bacterial microbiota was predicted. This work would provide theoretical support for discovering microbial resources and building artificial microbial flora.

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Section: Discussionmentioning

confidence: 99%

Diversity Shifts in the Root Microbiome of Cucumber Under Different Plant Cultivation Substrates

Zhou

Gao

et al. 2022

Front. Microbiol.

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“…Sesquiterpenoids are the most abundant members of natural terpenoids because of their various structures and notable bioactivities. The chemical components of sesquiterpenoids had been found in plants, animals, microorganisms and marine organisms [ 117 , 118 ]. A series of sesquiterpenoids ( 175 – 184 and 195 ) were isolated from a strain of Phomopsis sp.…”

Section: Bioactive Secondary Metabolites From Phomopsis mentioning

confidence: 99%

Bioactive Secondary Metabolites of the Genus Diaporthe and Anamorph Phomopsis from Terrestrial and Marine Habitats and Endophytes: 2010–2019

Wang

et al. 2021

Microorganisms

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The genus Diaporthe and its anamorph Phomopsis are distributed worldwide in many ecosystems. They are regarded as potential sources for producing diverse bioactive metabolites. Most species are attributed to plant pathogens, non-pathogenic endophytes, or saprobes in terrestrial host plants. They colonize in the early parasitic tissue of plants, provide a variety of nutrients in the cycle of parasitism and saprophytism, and participate in the basic metabolic process of plants. In the past ten years, many studies have been focused on the discovery of new species and biological secondary metabolites from this genus. In this review, we summarize a total of 335 bioactive secondary metabolites isolated from 26 known species and various unidentified species of Diaporthe and Phomopsis during 2010–2019. Overall, there are 106 bioactive compounds derived from Diaporthe and 246 from Phomopsis, while 17 compounds are found in both of them. They are classified into polyketides, terpenoids, steroids, macrolides, ten-membered lactones, alkaloids, flavonoids, and fatty acids. Polyketides constitute the main chemical population, accounting for 64%. Meanwhile, their bioactivities mainly involve cytotoxic, antifungal, antibacterial, antiviral, antioxidant, anti-inflammatory, anti-algae, phytotoxic, and enzyme inhibitory activities. Diaporthe and Phomopsis exhibit their potent talents in the discovery of small molecules for drug candidates.

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“…Numerous studies have been performed on the isolation and chemical and biological characterization, and these studies are still increasing. These investigations have also confirmed that families such as alkaloids [ 1 ], peptides [ 2 ], phenoxazines [ 3 ], amines [ 4 ], or nitrogenous sesquiterpenoids [ 5 ] could show outstanding activities of pharmacological or agronomic interest. The alkaloid family is one of the most relevant of these, given its production by a wide range of living beings, its structural variety, as well as the biological activities that have been discovered a long time ago.…”

Section: Introductionmentioning

confidence: 81%

Structures and Biological Activities of Alkaloids Produced by Mushrooms, a Fungal Subgroup

Zorrilla

Evidente

2022

Biomolecules

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Alkaloids are a wide family of basic N-containing natural products, whose research has revealed bioactive compounds of pharmacological interest. Studies on these compounds have focused more attention on those produced by plants, although other types of organisms have also been proven to synthesize bioactive alkaloids, such as animals, marine organisms, bacteria, and fungi. This review covers the findings of the last 20 years (2002–2022) related to the isolation, structures, and biological activities of the alkaloids produced by mushrooms, a fungal subgroup, and their potential to develop drugs and agrochemicals. In some cases, the synthesis of the reviewed compounds and structure−activity relationship studies have been described.

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Natural Nitrogenous Sesquiterpenoids and Their Bioactivity: A Review

Cited by 19 publications

References 96 publications

Diversity Shifts in the Root Microbiome of Cucumber Under Different Plant Cultivation Substrates

Diversity Shifts in the Root Microbiome of Cucumber Under Different Plant Cultivation Substrates

Bioactive Secondary Metabolites of the Genus Diaporthe and Anamorph Phomopsis from Terrestrial and Marine Habitats and Endophytes: 2010–2019

Structures and Biological Activities of Alkaloids Produced by Mushrooms, a Fungal Subgroup

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