Natural plant products in treatment of pulmonary arterial hypertension

Abstract

Pulmonary arterial hypertension (PAH) is a severe disease characterized by progressive remodeling of distal pulmonary arteries and persistent elevation of pulmonary vascular resistance (PVR), which leads to right ventricular dysfunction, heart failure, and eventually death. Although treatment responsiveness for this disease is improving, it continues to be a life-threatening condition. With the clinical efficacy of natural plant products being fully confirmed by years of practice, more and more recognition and attention have been obtained from the international pharmaceutical industry. Moreover, studies over the past decades have demonstrated that drugs derived from natural plants show unique advantages and broad application prospects in PAH treatment, not to mention the historical application of Chinese traditional medicine in cardiopulmonary diseases. In this review, we focus on summarizing natural plant compounds with therapeutic properties in PAH, according to the extracts, fractions, and pure compounds from plants into categories, hoping it to be helpful for basic research and clinical application.

Chrysin ameliorates ANTU‐induced pulmonary edema and pulmonary arterial hypertension via modulation of VEGF and eNOs

“…In the last couple of decades, management of PAH by using moieties from herbal origin are gaining more significant attention. An array of herbal plants such as Ligusticum wallichii , Salvia miltiorrhiza and Radix Astragali have been evaluated for their potential against PAH clinically . Thus, treatment of toxicants induced PAH by using natural remedies such as chrysin may provide safe and alternative therapeutic options.…”

Nanophytomedicines for the Prevention of Metabolic Syndrome: A Pharmacological and Biopharmaceutical Review

“…Oxidative stress, nitric oxide, and inflammation participate in the development of PAH (Xu et al, 2017). Antioxidant and anti-inflammatory effects of phytochemicals make them a promising option for treating PAH (Xu D. et al, 2016;Meghwani et al, 2018;Xiang et al, 2018). Copaiba oil is an oil-resin that is produced from different species of the genus of Copaifera and is used in Brazilian traditional medicine (Kanis et al, 2012).…”

Uncaria tomentosa (Willd. ex Schult.) DC.: A Review on Chemical Constituents and Biological Activities

“…Additionally, U. tomentosa stem bark extracts have been revealed to stimulate the in vitro production of IL-6 and IL-1 in rat alveolar and lipopolysaccharide-stimulated macrophages in a dose-related manner and its suppressive activities on cancer cell multiplication appear to be due to apoptosis induction [18,32]. Moreover, Xiao et al [33] examined the hypotensive efficacy of isorhynchophylline in rats and dogs, whereas Xiang et al [34] documented the ability of rhynchophylline to suppress rabbit and rat platelet accumulation ex vivo. Additionally, the anti-inflammatory activity of the standardized aqueous extract of U. tomentosa (AC 11 of U. tomentosa extract) was attributed to NF-κB inhibition [35].…”