Uncaria tomentosa (Willd. ex Schult.) DC.: A Review on Chemical Constituents and Biological Activities

Batiha, Gaber El‐Saber; Beshbishy, Amany Magdy; Wasef, Lamiaa; Elewa, Yaser Hosny Ali; El‐Hack, Mohamed E. Abd; Taha, Ayman E.; Al‐Sagheer, Adham A.; Devkota, Hari Prasad; Tufarelli, Vincenzo

doi:10.3390/app10082668

Cited by 51 publications

(49 citation statements)

References 60 publications

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“…This study was performed to identify whether certain components of U. tomentosa extracts have potential therapeutic effects against COVID-19. To this purpose, a database of 26 compounds that have shown prevalence on the herbal therapeutic activity has been generated ( Figure 1) (Aquino et al, 1990(Aquino et al, , 1997Batiha et al, 2020;Keplinger et al, 1998;Kitajima et al, 2000;Lima-Junior et al, 2013;Lock et al, 2016;Montoro et al, 2004;Navarro et al, 2019Pavei et al, 2012;Peñaloza et al, 2015;Snow et al, 2019;Vera-Reyes et al, 2015). Our initial hypothesis is that cat's claw should contain molecules with highest therapeutic profiles against SARS-CoV-2, by disrupting SARS-CoV-2/ACE-2 association or by inhibiting SARS-CoV-2 spike protein.…”

Section: Database Of U Tomentosa Bioactive Compoundsmentioning

confidence: 99%

“…Bioactive constituents of U. tomentosa extracts include proanthocyanidins [proanthocyanidin B2 (the main component), proanthocyanidin B4, proanthocyanidin C1, an epicatechin trimer, epiafzelechin-4b!8-epicatechin and an epicatechin tetramer] (Batiha et al, 2020;Navarro-Hoyos et al, 2017), oxindole alkaloids (isopteropodine, pteropodine, rhynchophylline, mytraphylline, speciophylline, uncarine F and uncarine E), indole alkaloidal glucosides (cadambine, 3dihydrocadambine and 3-isodihydrocadambine) (Batiha et al, 2020;Kura s et al, 2009;Laus et al, 1997;Lima-Junior et al, 2013;Lock et al, 2016;Navarro et al, 2019Snow et al, 2019), quinovic acid glycosides (Pavei et al, 2012), tannins (Ostrakhovich et al, 1997), polyphenols, catechins, beta sitosterol (Aquino et al, 1997;Navarro et al, 2019) and proteins (Lenzi et al, 2013), which individually or synergistically contribute to their therapeutic properties.…”

Section: Introductionmentioning

confidence: 99%

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Uncaria tomentosa(cat’s claw): a promising herbal medicine against SARS-CoV-2/ACE-2 junction and SARS-CoV-2 spike protein based on molecular modeling

Yepes-Pérez

Herrera-Calderon

Quintero‐Saumeth

2020

Journal of Biomolecular Structure and Dynamics

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COVID-19 is a novel severe acute respiratory syndrome coronavirus. Currently, there is no effective treatment and vaccines seem to be the solution in the future. Virtual screening of potential drugs against the S protein of severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) has provided small molecular compounds with a high binding affinity. Unfortunately, most of these drugs do not attach with the binding interface of the receptor-binding domain (RBD)-angiotensin-converting enzyme-2 (ACE-2) complex in host cells. Molecular modeling was carried out to evaluate the potential antiviral properties of the components of the medicinal herb Uncaria tomentosa (cat's claw) focusing on the binding interface of the RBD-ACE-2 and the viral spike protein. The in silico approach starts with protein-ligand docking of 26 Cat's claw key components followed by molecular dynamics simulations and re-docked calculations. Finally, we carried out drug-likeness calculations for the most qualified cat's claw components. The structural bioinformatics approaches led to the identification of several bioactive compounds of U. tomentosa with potential therapeutic effect by dual strong interaction with interface of the RBD-ACE-2 and the ACE-2 binding site on SARS-CoV-2 RBD viral spike. In addition, in silico drug-likeness indices for these components were calculated and showed good predicted therapeutic profiles of these phytochemicals found in U. tomentosa (cat's claw). Our findings suggest the potential effectiveness of cat's claw as complementary and/or alternative medicine for COVID-19 treatment.

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Section: Database Of U Tomentosa Bioactive Compoundsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Uncaria tomentosa(cat’s claw): a promising herbal medicine against SARS-CoV-2/ACE-2 junction and SARS-CoV-2 spike protein based on molecular modeling

Yepes-Pérez

Herrera-Calderon

Quintero‐Saumeth

2020

Journal of Biomolecular Structure and Dynamics

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“…The results from this study demonstrated that exposure to FA led to a significant decline in antioxidant markers [ 52 ], with a concomitant increase in liver transaminases, lipid profile as well as inflammatory markers [ 53 ]. Additionally, G. lucidum possesses protective roles as it has the ability to restore antioxidant, lipid profile and anti-inflammatory statuses.…”

Section: Discussionmentioning

confidence: 99%

Ganoderma Lucidum from Red Mushroom Attenuates Formaldehyde-Induced Liver Damage in Experimental Male Rat Model

Adetuyi¹,

Okeowo

Adetuyi

et al. 2020

Biology

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The majority of liver-related illnesses are caused by occupational and domestic exposure to toxic chemicals like formaldehyde (FA), which is widely common in Africa and the world at large. Hence, measures should be taken to protect humans from its hazardous effects. This study, therefore, examines the protective potential of Ganoderma lucidum (100 mg/kg body weight) on formaldehyde-induced (40%) liver oxido-inflammation in male rats. Male Wistar rats, 150–200 g, were allotted into four groups of 10 animals as follows: Group 1 was orally treated with 1 mg/mL distilled water, Group 2 was exposed to a 40% formaldehyde vapor environment for 30 min per day, Group 3 was orally treated with 100 mg/kg ethanol extract of Ganoderma lucidum, and Group 4 was co-administered formaldehyde and 100 mg/kg ethanol extract of Ganoderma lucidum. Rats were then sacrificed 24 h after administering the last dose of treatment, and the livers were excised. Ganoderma lucidum significantly reversed the formaldehyde-mediated reduction in body and organ weight. Ganoderma lucidum administration significantly prevented oxido-inflammation by reducing the levels of hydrogen peroxide and malondialdehyde and increasing the activity of antioxidant enzymes and glutathione contents, as well as the normal level of nitrite and myeloperoxidase production in FA-treated rats. Additionally, Ganoderma lucidum reversed a large decline in proinflammatory markers in formaldehyde. Furthermore, Ganoderma lucidum restores formaldehyde-induced histological alterations in the liver. Collectively, our results provide valuable information on the protective potential of Ganoderma lucidum in protecting formaldehyde-induced liver oxido-inflammation in male rats.

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“…Medicinal plants have been used for various therapeutic purposes. U. tomentosa has been traditionally used to treat asthma, abscesses, fever, urinary tract infections, viral infections, and wounds (Batiha et al, 2020). It also has been used to treating diabetes, cancer, intestinal affections inflammation, cancer, menstrual disorders (de Paula et al, 2015;Zhang et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

“…U. tomentosa has several pharmacological activities such as antitumor, anticancer, antioxidant, anti-neoplastic, antiinflammation, antimicrobial, antiprotozoal, and antiviral activities (Batiha et al, 2020). Cytotoxic activity of ethanol extract from hooks U. tomentosa from West Kalimantan is not known.…”

Section: Introductionmentioning

confidence: 99%

Cytotoxicity Activities of Ethanol Extract of Hooks Uncaria tomentosa West Kalimantan

Sofiana

Warsidah

Iskandar³

2020

J Food Med Plants

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Uncaria tomentosa is a member of the plant family Rubiaceae. It has been used as medicinal plants in West Kalimantan. The cytotoxic of ethanol extract from the hooks of U. Tomentosa was determined. This study used Brine Shrimp Lethality Test (BSLT) method with solution concentration 1,000; 5,000 and 10,000 ppm. The extract has LC50 values of 21,754 ppm. It is indicated the extract not toxic. This extract is potent to be used as drugs.

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Uncaria tomentosa (Willd. ex Schult.) DC.: A Review on Chemical Constituents and Biological Activities

Cited by 51 publications

References 60 publications

Uncaria tomentosa(cat’s claw): a promising herbal medicine against SARS-CoV-2/ACE-2 junction and SARS-CoV-2 spike protein based on molecular modeling

Uncaria tomentosa(cat’s claw): a promising herbal medicine against SARS-CoV-2/ACE-2 junction and SARS-CoV-2 spike protein based on molecular modeling

Ganoderma Lucidum from Red Mushroom Attenuates Formaldehyde-Induced Liver Damage in Experimental Male Rat Model

Cytotoxicity Activities of Ethanol Extract of Hooks Uncaria tomentosa West Kalimantan

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