Natural Polyphenols for Prevention and Treatment of Cancer

Zhou, Yue; Zheng, Jie; Li, Ya; Xu, Dong-ping; Li, Sha; Chen, Yuming; Li, Hua-Bin

doi:10.3390/nu8080515

Cited by 577 publications

(475 citation statements)

References 199 publications

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“…Suppression of oxidative stress has been considered to be a viable approach in treating cancer44. Thus, many anti-oxidant reagents like polyphenols, flavonoids and so on, are considered to be potential anti-cancer drug candidates45464748. Although SM had a strong anti-oxidant activity in vitro (Fig.…”

Section: Discussionmentioning

confidence: 99%

Shengmai Formula suppressed over-activated Ras/MAPK pathway in C. elegans by opening mitochondrial permeability transition pore via regulating cyclophilin D

Liu

Zhi

et al. 2016

Sci Rep

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Since about 30% of all human cancers contain mutationally activated Ras, down regulating the over-activation of Ras/MAPK pathway represents a viable approach for treating cancers. Over-activation of Ras/MAPK pathway is accompanied by accumulation of reactive oxygen species (ROS). One approach for developing anti-cancer drugs is to target ROS production and their accumulation. To test this idea, we have employed C. elegans of let-60 (gf) mutant, which contain over-activated let-60 (the homolog of mammalian ras) and exhibit tumor-like symptom of multivulva phenotype, to determine whether anti-oxidants can affect their tumor-like phenotype. Specifically we studied the effect of Shengmai formula (SM), a traditional Chinese medicine that has strong anti-oxidant activity, on the physiology of let-60 (gf) mutants. Unexpectedly, we found that SM treatment led to the opening of mitochondrial permeability transition pore by regulating cyclophilin D and then triggered oxidative stress and related signaling pathway activation, including p53, JNK, and p38/MAPK pathways. Finally, SM induced mitochondrial pathway of apoptosis and inhibited the tumor-like symptom of the multivulva phenotype of let-60(gf) mutants. Our results provide evidences to support that SM act as a pro-oxidant agent and could serve as a potential drug candidate for combating over-activated Ras-related cancer.

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Section: Discussionmentioning

confidence: 99%

Shengmai Formula suppressed over-activated Ras/MAPK pathway in C. elegans by opening mitochondrial permeability transition pore via regulating cyclophilin D

Liu

Zhi

et al. 2016

Sci Rep

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“…Flavonoids are a wide range of natural compounds that have been intensively studied for their anticancer properties [18, 19]. Interestingly, some flavonoid compounds exert their effects through activation of Ahr [20, 21].…”

Section: Introductionmentioning

confidence: 99%

Novel Aryl Hydrocarbon Receptor Agonist Suppresses Migration and Invasion of Breast Cancer Cells

et al. 2016

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BackgroundDespite the remarkable progress to fight against breast cancer, metastasis remains the dominant cause of treatment failure and recurrence. Therefore, control of invasiveness potential of breast cancer cells is crucial. Accumulating evidences suggest Aryl hydrocarbon receptor (Ahr), a helix-loop-helix transcription factor, as a promising target to control migration and invasion in breast cancer cells. Thus, an Ahr-based exploration was performed to identify a new Ahr agonist with inhibitory potentials on cancer cell motility.MethodsFor prediction of potential interactions between Ahr and candidate molecules, bioinformatics analysis was carried out. The interaction of the selected ligand with Ahr and its effects on migration and invasion were examined in vitro using the MDA-MB-231 and T47D cell lines. The silencing RNAs were transfected into cells by electroporation. Expressions of microRNAs (miRNAs) and coding genes were quantified by real-time PCR, and the protein levels were detected by western blot.ResultsThe in silico and in vitro results identified Flavipin as a novel Ahr agonist. It induces formation of Ahr/Ahr nuclear translocator (Arnt) heterodimer to promote the expression of cytochrome P450 family 1 subfamily A member 1 (Cyp1a1). Migration and invasion of MDA-MB-231 and T47D cells were inhibited with Flavipin treatment in an Ahr-dependent fashion. Interestingly, Flavipin suppressed the pro-metastatic factor SRY-related HMG-box4 (Sox4) by inducing miR-212/132 cluster. Moreover, Flavipin inhibited growth and adhesion of both cell lines by suppressing gene expressions of B-cell lymphoma 2 (Bcl2) and integrinα4 (ITGA4).ConclusionTaken together, the results introduce Flavipin as a novel Ahr agonist, and provide first evidences on its inhibitory effects on cancer cell motility, suggesting Flavipin as a candidate to control cell invasiveness in breast cancer patients.

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“…Esto se debe a que sus distintas estructuras moleculares modifican la biodisponibilidad y bioactividad de los mismos. 29,30 Los efectos hallados para estos flavonoides dependen de su acción sobre la glándula mamaria, 21,31,32 lo cual se condiciona por la presencia de metales en la leche, y favorece la actividad oxidante de flavanonas y flavanoles. 33 Esto puede suceder en la mama debido a la capacidad de ésta para concentrar hierro y con ello promover la formación de anión superóxido.…”

Section: Discussionunclassified

Modificaciones en el nivel de anión superóxido en leche materna, según la ingesta de flavonoides y carotenoides

et al. 2017

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Natural Polyphenols for Prevention and Treatment of Cancer

Cited by 577 publications

References 199 publications

Shengmai Formula suppressed over-activated Ras/MAPK pathway in C. elegans by opening mitochondrial permeability transition pore via regulating cyclophilin D

Shengmai Formula suppressed over-activated Ras/MAPK pathway in C. elegans by opening mitochondrial permeability transition pore via regulating cyclophilin D

Novel Aryl Hydrocarbon Receptor Agonist Suppresses Migration and Invasion of Breast Cancer Cells

Modificaciones en el nivel de anión superóxido en leche materna, según la ingesta de flavonoides y carotenoides

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