Natural polyphenols in preclinical models of epilepsy

Dhir, Ashish

doi:10.1002/ptr.6617

Cited by 22 publications

(11 citation statements)

References 104 publications

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“…In recent decades, the search for natural sources of biologically active substances has become highly acute despite the large number of synthetic drugs used in modern medicine [1,2]. It is known that the use of herbal drugs is explained not only by their high biological activity, but also by the absence of adverse reactions inherent in synthetic drugs [3,4].…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and Antiradical Properties of Some Examples of Flavonoids and Coumarins—Potentiometric Studies

et al. 2021

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A comprehensive study of a range of flavonoids and coumarins is presented in this article. The work uses an approach that evaluates the activity of these compounds by various mechanisms: the electron transfer (ET), the hydrogen atom transfer (HAT), and the mechanism of metal chelation. The studies were carried out using the methods of the cyclic voltammetry and the potentiometry. The electrochemical behavior of these compounds was studied by the method of cyclic voltammetry; the main types of voltammograms, depending on the oxidation mechanisms, were identified. Various versions of potentiometric sensor systems have been used to detect analytical signal in approaches implemented in ET, HAT and metal chelation mechanisms. The antioxidant capacity was studied by the electron-transfer mechanism. Compounds with antioxidant properties were selected; half-reaction periods for these compounds have been determined. It has been shown that electron-donating and complexing properties directly depend on the mutual arrangement of hydroxyl groups in the molecule. The antiradical ability of the compounds has been studied. It was shown that all studied compounds inhibit peroxyl radicals. Series on the change in antioxidant and antiradical properties of compounds have been compiled. There is no correlation between the results of the study of antioxidant properties obtained using sensory systems that reveal various antioxidant mechanisms. The need to use an integrated approach in the study of antioxidant properties is shown.

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Section: Introductionmentioning

confidence: 99%

Antioxidant and Antiradical Properties of Some Examples of Flavonoids and Coumarins—Potentiometric Studies

et al. 2021

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“…Recently, compounds found in plant products have received large interest in the development of new treatments against epilepsy (Pina et al, 2022; Schachter, 2009; Sucher & Carles, 2015). Among these compounds, stilbenes (e.g., resveratrol, pterostilbene, and piceatannol) are known to have beneficial effects in preclinical models of seizures and epilepsy (Dhir, 2020).…”

Section: Stilbenes In Neuropsychiatric and Neurological Disordersmentioning

confidence: 99%

Therapeutic potential of stilbenes in neuropsychiatric and neurological disorders: A comprehensive review of preclinical and clinical evidence

Socała,

Żmudzka,

Lustyk

et al. 2024

Phytotherapy Research

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Neuropsychiatric disorders are anticipated to be a leading health concern in the near future, emphasizing an outstanding need for the development of new effective therapeutics to treat them. Stilbenes, with resveratrol attracting the most attention, are an example of multi‐target compounds with promising therapeutic potential for a broad array of neuropsychiatric and neurological conditions. This review is a comprehensive summary of the current state of research on stilbenes in several neuropsychiatric and neurological disorders such as depression, anxiety, schizophrenia, autism spectrum disorders, epilepsy, traumatic brain injury, and neurodegenerative disorders. We describe and discuss the results of both in vitro and in vivo studies. The majority of studies concentrate on resveratrol, with limited findings exploring other stilbenes such as pterostilbene, piceatannol, polydatin, tetrahydroxystilbene glucoside, or synthetic resveratrol derivatives. Overall, although extensive preclinical studies show the potential benefits of stilbenes in various central nervous system disorders, clinical evidence on their therapeutic efficacy is largely missing.

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“…Pharmacological effects described for resveratrol include antiepileptic, anti-inf lammatory, antioxidant, anti-tumorigenic, neuroprotective, and hypertensive activities (Repossi, Das, Eynard, 2020;Tian, Liu, 2020). A series of recent studies show that resveratrol displays multiple effects on the central nervous system, such as antidepressant, anticonvulsant, anti-neurodegenerative, antinociceptive, anxiolytic, and sedative effects (Dhir, 2020;Repossi, Das, Eynard, 2020;Singh et al, 2019). Treatment with resveratrol was well tolerated, without severe adverse events, and with no treatment-related effects (Repossi, Das, Eynard, 2020).…”

Section: Introductionmentioning

confidence: 96%

Resveratrol inhibits nicotine-induced conditioned place preference in mice

Yunusoğlu

2023

Braz. J. Pharm. Sci.

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Nicotine addiction leads to in a huge burden on public health and the economy worldwide. Resveratrol (3,5, is the most well-known polyphenolic stilbenoid. Resveratrol was shown to exhibit positive effects on numerous mechanisms that are important for drug and substance addiction. Thus, this study aimed to examine the effect of resveratrol on nicotine addiction. Intraperitoneal (i.p.) treatment with nicotine (0.5 mg/kg) significantly enhanced time spent in the nicotine-paired compartment. Resveratrol (50 and 75 mg/kg, i.p.) and varenicline (2 mg/kg, i.p.) co-administered with nicotine during the 3-day conditioning period effectively diminished the acquisition of nicotine-induced conditioned place preference (CPP). On the other hand, the administration of resveratrol (50 and 75 mg/kg, i.p.) and varenicline (2 mg/kg, i.p.) decreased the low dose (0.1 mg/kg, i.p.) nicotine-induced reinstatement. The results suggest that resveratrol and varenicline inhibit the acquisition and reinstatement of nicotine's reward properties. Resveratrol displayed similar results in the CPP phases as obtained with the reference drug varenicline. In conclusion, resveratrol could be beneficial as an adjuvant pharmacotherapy for nicotine addiction; however, more investigation is needed to completely explain this property.

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Natural polyphenols in preclinical models of epilepsy

Cited by 22 publications

References 104 publications

Antioxidant and Antiradical Properties of Some Examples of Flavonoids and Coumarins—Potentiometric Studies

Antioxidant and Antiradical Properties of Some Examples of Flavonoids and Coumarins—Potentiometric Studies

Therapeutic potential of stilbenes in neuropsychiatric and neurological disorders: A comprehensive review of preclinical and clinical evidence

Resveratrol inhibits nicotine-induced conditioned place preference in mice

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