Natural Polysaccharide based Nanoparticles for Drug/Gene Deliv­ery

Salatin, Sara; Jelvehgari, Mitra

doi:10.15171/ps.2017.14

Cited by 32 publications

(22 citation statements)

References 89 publications

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“…Concerning cationic polyelectrolytes, chitosan, which is composed of repeated units of d -glucosamine, has been described as a non-toxic, biodegradable, and bioadhesive material that provides the advantages of control of release of encapsulated agents, complexation with negative charged macromolecules, avoidance of toxic solvents during preparation, and prolonged residence time at the site of absorption due to its mucoadhesive nature [ 62 ]. Indeed, the latter is one of the major advantages for the administration of compounds of interests against nasal, oral, ocular, and dermal disorders [ 63 ].…”

Section: Biocompatible and Biodegradable Nanoparticles: Looking Fomentioning

confidence: 99%

“…Indeed, the latter is one of the major advantages for the administration of compounds of interests against nasal, oral, ocular, and dermal disorders [ 63 ]. Several factors condition the preparation, conformation, and loading of chitosan nanoparticles, affecting their ability to delivery compounds [ 62 ]. In addition, chitosan nanoparticles are suitable to be modified by adding specific ligands that contribute to a more rapid and efficient interaction with cells membranes, and thus, to an enhanced delivery of bioactive compounds [ 64 ].…”

Section: Biocompatible and Biodegradable Nanoparticles: Looking Fomentioning

confidence: 99%

“…In respect to anionic polysaccharide nanoparticles alginate, heparin, pectin, and hyaluronic acid are important to mention [ 62 ]. An overview of the interest of these nanoparticles indicates that alginate features biocompatibility, biodegradability, non-antigenicity, and mucoadhesive features [ 65 , 66 , 67 ], which make it an interesting candidate for controlled delivery of bioactive compounds [ 62 ].…”

Section: Biocompatible and Biodegradable Nanoparticles: Looking Fomentioning

confidence: 99%

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Nanoparticles and Controlled Delivery for Bioactive Compounds: Outlining Challenges for New “Smart-Foods” for Health

Martínez-Ballesta

Gil-Izquierdo

García‐Viguera

et al. 2018

Foods

186

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Nanotechnology is a field of research that has been stressed as a very valuable approach for the prevention and treatment of different human health disorders. This has been stressed as a delivery system for the therapeutic fight against an array of pathophysiological situations. Actually, industry has applied this technology in the search for new oral delivery alternatives obtained upon the modification of the solubility properties of bioactive compounds. Significant works have been made in the last years for testing the input that nanomaterials and nanoparticles provide for an array of pathophysiological situations. In this frame, this review addresses general questions concerning the extent to which nanoparticles offer alternatives that improve therapeutic value, while avoid toxicity, by releasing bioactive compounds specifically to target tissues affected by specific chemical and pathophysiological settings. In this regard, to date, the contribution of nanoparticles to protect encapsulated bioactive compounds from degradation as a result of gastrointestinal digestion and cellular metabolism, to enable their release in a controlled manner, enhancing biodistribution of bioactive compounds, and to allow them to target those tissues affected by biological disturbances has been demonstrated.

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Section: Biocompatible and Biodegradable Nanoparticles: Looking Fomentioning

confidence: 99%

Section: Biocompatible and Biodegradable Nanoparticles: Looking Fomentioning

confidence: 99%

Section: Biocompatible and Biodegradable Nanoparticles: Looking Fomentioning

confidence: 99%

See 1 more Smart Citation

Nanoparticles and Controlled Delivery for Bioactive Compounds: Outlining Challenges for New “Smart-Foods” for Health

Martínez-Ballesta

Gil-Izquierdo

García‐Viguera

et al. 2018

Foods

186

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“…Previous studies have also suggested that the positively charged NPs show an increased cellular uptake when compared to the negatively charged NPs. 36,37…”

Section: Fluorescence Microscopymentioning

confidence: 99%

Formulation and Evaluation of Eudragit RL-100 Nanoparticles Loaded In-Situ Forming Gel for Intranasal Delivery of Rivastigmine

et al. 2019

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Purpose: Rivastigmine hydrogen tartrate (RHT) is commonly used for the treatment of mild to moderate Alzheimer’s disease (AD). The aim of this work was to formulate in-situ pluronic F-127 (PF-127) hydrogels containing Eudragit RL-100 (EU-RL) nanoparticles (NPs) in order to improve the therapeutic efficacy of RHT through the nasal route. Methods: The NPs were prepared using different polymer to drug ratios and evaluated for their physicochemical characteristics, cellular uptake and in vitro cytotoxicity against lung adenocarcinoma cells (A459). PF-127 nanoformulations were prepared via cold method and analyzed in terms of physicochemical properties and drug release profiles. The nanoformulations and plain drug gel were then assessed by ex vivo permeation studies across the sheep nasal mucosa. Results: The EU-RL NPs exhibited a particle size within the range of 118 to 154 nm and positive zeta potential values of 22.5 to 30 mV with an approximately spherical shape. Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), and X-ray powder diffraction (XRPD) suggested no drug to polymer interaction through the preparation of nanoformulations. The RHT-loaded NPs exhibited an acceptable cytocompatibility with a time- and dose-dependent cellular internalization. Conclusion: Our results clearly indicated the potential of nanoformulations as controlled release systems to improve the therapeutic efficacy of RHT through the intranasal administration

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“…Peyer's patches are the follicles of lymphoid tissue containing M-cells, having an important function in the uptake of particles. The size and surface charge are the most important factors affecting the uptake of particles by M-cells [16]. Polymeric nanoparticles have been established extensively to elevate the biological half-life of therapeutic proteins and peptides by entrapment and encapsulation.…”

Section: Mucoadhesive Nanoparticlesmentioning

confidence: 99%

Oral delivery of proteins and peptides by mucoadhesive nanoparticles

2019

Biointerface Res Appl Chem

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It seems that an ever growing tendency is necessary for the development of a strategy that can not only protect the peptides and proteins from degradation by the enzymes but also can improve their absorption without affecting biological activity. Delivery of peptides and proteins into the oral cavity remains an interesting approach, however for its availability some distinctive problems should be addressed. A wide variety of carriers have been investigated for delivery of peptides and proteins for the protection of their formulation and structure against the enzymatic environment of the gastrointestinal tract.

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Natural Polysaccharide based Nanoparticles for Drug/Gene Delivery

Cited by 32 publications

References 89 publications

Nanoparticles and Controlled Delivery for Bioactive Compounds: Outlining Challenges for New “Smart-Foods” for Health

Nanoparticles and Controlled Delivery for Bioactive Compounds: Outlining Challenges for New “Smart-Foods” for Health

Formulation and Evaluation of Eudragit RL-100 Nanoparticles Loaded In-Situ Forming Gel for Intranasal Delivery of Rivastigmine

Oral delivery of proteins and peptides by mucoadhesive nanoparticles

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Natural Polysaccharide based Nanoparticles for Drug/Gene Deliv­ery

Cited by 32 publications

References 89 publications

Nanoparticles and Controlled Delivery for Bioactive Compounds: Outlining Challenges for New “Smart-Foods” for Health

Nanoparticles and Controlled Delivery for Bioactive Compounds: Outlining Challenges for New “Smart-Foods” for Health

Formulation and Evaluation of Eudragit RL-100 Nanoparticles Loaded In-Situ Forming Gel for Intranasal Delivery of Rivastigmine

Oral delivery of proteins and peptides by mucoadhesive nanoparticles

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Product

Resources

About

Natural Polysaccharide based Nanoparticles for Drug/Gene Delivery