Natural product sciences: an integrative approach to the innovations of plant natural products

Abstract

The study on plant natural products not only helps us understand that their structural diversity is the inevitable result of plant species diversity, but also helps us understand certain rules and unity of the inevitable connection between the two. The diversity and complexity of chemical structures of many natural products are beyond imagination before we elucidated their structures. The question that follows is what is the biological significance of these natural products. Intrigued by the relationship between plant resources, natural products and biological functions, the Hao laboratory has taken an integrative approach that employs tools and knowledge from multi-disciplines, including natural product chemistry, chemical ecology and chemical biology, to unveil the effects of plant natural products on plant resistance to diseases, and environmental acclimations. Collaborating with cell biologists, the research has resulted in discovery of new mechanisms of cellular signaling and lead compounds.

An efficient removal mechanism for different hydrophilic antibiotics from aquatic environments by Cu–Al–Fe–Cr quasicrystals

“…1 However, since most antibiotics are challenging for organisms to fully digest, they and their metabolites are discharged into the environment through excretions and urine. 2,3 Even though antibiotic concentrations are oen detected at trace levels in the environment, they can still induce antibiotic resistance genes at a low concentration. 4 It can enhance the resistance of bacteria to drugs and have great hidden dangers for the evolution of the bacterial community structure.…”

Toad Alkaloid for Pesticide Discovery: Dehydrobufotenine Derivatives as Novel Agents against Plant Virus and Fungi

“…Natural products are small molecular compounds produced by animals, plants, or microorganisms. Since the first isolation of morphine, more than 300,000 natural products have been reported . These natural products have structural diversity and broad-spectrum biological activities, many of which have been developed into medicines or pesticides, such as aspirin, penicillin, vancomycin, taxol, artemisinin, avermectins, pyrethrins, and azadirachtins.…”

Integrated molecular network and HPLC‐UV‐FLD analysis to explore antioxidant ingredients in camellia nitidissima Chi

“…Molecular Network (MN) is a tandem mass spectrometry (MS) data organization method that has been introduced in the fields of drug discovery, metabolomics, and medicine fields (Quinn et al., 2017). It has a useful application in studying natural products derived from microorganisms, marine organisms, fungi, plants, and others (Allard et al., 2016; Arbour, & Imperiali, 2020; Shen, & Hao, 2020; Zhang et al., 2018). The strategy is based on comparing the theoretical MS/MS spectra with the original MS/MS spectra to establish a relative network.…”