Natural products against cancer: A comprehensive bibliometric study of the research projects, publications, patents and drugs

Du, Jian; Tang, Xiaoli

doi:10.4103/0973-1482.139750

Cited by 27 publications

(9 citation statements)

References 19 publications

(23 reference statements)

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“…Natural antioxidant-enriched compounds showed robust defense mechanisms in contrast to the cellular damage caused by free-radical-induced oxidative stress [11,12,13]. Antioxidant-enriched bioactive compounds of plants are particularly useful for precluding cancer by inducing the apoptosis of cancer cells [14,15,16]. Thus, it is significant and obligatory to quantitatively and qualitatively analyze polyphenol compounds and their antioxidant and cytotoxic properties.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Antioxidant and Cytotoxic Activities of Extracts of Dendrobium crepidatum

et al. 2019

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Dendrobium crepidatum is an epiphytic orchid found in south Asia including Nepal and China. This orchid species is widely used in traditional Chinese medicine (TCM) for the treatment of cancer, diabetes, cataracts, and fever. The objectives of the present research were to assess the antioxidant and cytotoxic properties of its stem’s extracts with the identification of bioactive secondary metabolites. The antioxidant and cytotoxic activities were evaluated using the DPPH (2,2-diphenyl-1-picrylhydrazyl) and MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assays, respectively, and compounds were identified using GC–MS (gas chromatography and mass spectrometry). Ethanol and acetone extracts scavenged 94.69 ± 0.10% and 93.41 ± 0.86% of DPPH free radicals, respectively. They showed 50% inhibition of DPPH free radicals (IC50) at concentrations of 73.90 µg/mL and 99.44 µg/mL, which were found to be statistically similar to that of ascorbic acid (control). Chloroform extract inhibited the growth of 81.49 ± 0.43% of HeLa (human cervical carcinoma) cells and hexane extract inhibited the growth of 76.45 ± 4.26% of U251 (human glioblastoma) cells at 800 µg/mL concentration. These extracts showed 50% inhibition of cell growth (IC50) toward both the HeLa and U251 cell lines at their high concentrations, which were found statistically significantly different from that of cisplatin drug (control). The above extracts showed antioxidant and cytotoxic properties, potentially due to the presence of tetracosane, triacontane, stigmasterol, and some phenol derivatives (2-methoxy-4-vinylphenol, 2-methoxy-5-(1-propenyl)-phenol, p-mesyloxyphenol, and 2,6-dimethoxy-4-(2-propenyl)-phenol). This study explores the potential of this orchid in alternative medicine toward the development of drugs from its medicinally active compounds.

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Section: Introductionmentioning

confidence: 99%

Assessment of Antioxidant and Cytotoxic Activities of Extracts of Dendrobium crepidatum

et al. 2019

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“…Throughout the years, several strategies have been used to overcome or minimize side effects, including the search for natural anticancer agents, which are extensively associated to lower toxicity, due to their favorable body absorption and metabolism compared to conventional synthetic drugs [8]. Additionally, progress in cancer therapeutics has led to the development of nanosystems, including liposomes, to increase intracellular drug concentrations in cancerous cells while minimizing toxicity to normal cells [9], a non-specific characteristic of conventional treatments.…”

Section: Introductionmentioning

confidence: 99%

Liposomal Taro Lectin Nanocapsules Control Human Glioblastoma and Mammary Adenocarcinoma Cell Proliferation

et al. 2019

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The search for natural anticancer agents and nanocarrier uses are a part of the current strategies to overcome the side effects caused by chemotherapeutics. Liposomal nanocapsules loaded with purified tarin, a potential immunomodulatory and antitumoral lectin found in taro corms, were produced. Liposomes were composed by 1,2-dioleoyl-sn-glycerol-3-phosphoethanolamine, cholesterylhemisuccinate, and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[folate(polyethylene glycol)-2000 prepared by thin-film hydration. Small unilamellar vesicles were achieved by sonication and extrusion. Scanning electron microscopy evidenced round-shaped nanocapsules presenting a smooth surface, 150 nm diameter and polydispersity index <0.2, estimated by dynamic light scattering. Tarin entrapment rates were over 80% and leakage of ~3% under 40 days of storage at 4 °C. Entrapped tarin exhibited an 83% release after 6 h at pH 4.6–7.4 and 36 °C. Both free and encapsulated tarin exhibited no in vitro toxicity against healthy mice bone marrow and L929 cells but stimulated the production of fibroblast-like and large round-shaped cells. Encapsulated tarin resulted in inhibition of human glioblastoma (U-87 MG) and breast adenocarcinoma (MDA-MB-231) proliferation, with an IC50 of 39.36 and 71.38 µg/mL, respectively. The effectiveness of encapsulated tarin was similar to conventional chemotherapy drugs, such as cisplatin and temozolide. Tarin liposomal nanocapsules exhibited superior pharmacological activity compared to free tarin as a potential chemotherapy adjuvant.

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“…One year later, patent bibliometric analysis was used for tracking the R&D behavior in the pharmaceutical industry [ 7 ]. More recently, researchers had delineated the evolution of major research topics in the area of natural products against cancer with the patent data [ 8 ]. Particularly, in the field of nanotechnology, many scholars had characterized the growth, distribution, and trends via an integrated bibliometric analysis using data mining and content visualization tools [ 3 , 9 – 11 ].…”

Section: Introductionmentioning

confidence: 99%

Technology Resource, Distribution, and Development Characteristics of Global Influenza Virus Vaccine: A Patent Bibliometric Analysis

et al. 2015

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Influenza virus vaccine (IVV) is a promising research domain that is closely related to global health matters, which has been acknowledged not only by scientists and technology developers, but also by policy-makers. Meanwhile, patents encompass valuable technological information and reflect the latest technological inventions as well as the innovative capability of a nation. However, little research has examined this up-and-coming research field using patent bibliometric method. Thus, this paper (a) designs the technology classification system and search strategy for the identification of IVV; and (b) presents a longitudinal analysis of the global IVV development based on the European Patent Office (EPO) patents. Bibliometric analysis is used to rank countries, institutions, inventors and technology subfields contributing to IVV technical progress. The results show that the global trends of IVV are a multi-developing feature of variety but an uneven technical resource distribution. Although the synthetic peptide vaccine is a comparatively young field, it already demonstrates the powerful vitality and the enormous development space. With the worldwide competition increasing, all nations especially China should be looking to increase devotion, enhance capability and regard effectiveness of technological innovation.

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Natural products against cancer: A comprehensive bibliometric study of the research projects, publications, patents and drugs

Cited by 27 publications

References 19 publications

Assessment of Antioxidant and Cytotoxic Activities of Extracts of Dendrobium crepidatum

Assessment of Antioxidant and Cytotoxic Activities of Extracts of Dendrobium crepidatum

Liposomal Taro Lectin Nanocapsules Control Human Glioblastoma and Mammary Adenocarcinoma Cell Proliferation

Technology Resource, Distribution, and Development Characteristics of Global Influenza Virus Vaccine: A Patent Bibliometric Analysis

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