Natural Products Against COVID-19 Inflammation: A Mini-Review

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) is a virus whose genetic material is positive single-stranded RNA, being responsible for coronavirus disease 2019 (COVID-19), an infection that compromises the lungs and consequently the respiratory capacity of the infected individual, according to the WHO in November 2021, 249,743,428 cases were confirmed, of which 5,047,652 individuals died due to complications resulting from the infection caused by SARS-COV-2. As the infection progresses, the individual may experience loss of smell and taste, as well as breathing difficulties, severe respiratory failure, multiple organ failure, and death. Due to this new epidemiological agent in March 2020 it was announced by the director general of the World Health Organization (WHO) a pandemic status, and with that, many research groups are looking for new therapeutic alternatives through synthetic and natural bioactives. This research is a literature review of some in silico studies involving natural products against COVID-19 inflammation published in 2020 and 2021. Work like this presents relevant information to the scientific community, boosting future research and encouraging the use of natural products for the search for new antivirals against COVID-19.

Interleukin‐6 inhibitory effect of natural product naringenin compared to a synthesised monoclonal antibody against life‐threatening COVID‐19

“…However, patients with diabetes and another disease could interfere with Tocilizumab therapy, affecting the optimal management of SARS‐CoV‐2 infection. Natural products with easy distribution and low toxicity have gained a lot of attention based on their great antiviral activities against different viruses, especially against the life‐threatening coronavirus 104,105 . therefore, the discovery of new active compounds to develop anti‐inflammatory drugs is an essential step for Covid 19 treatment.…”

“…Natural products with easy distribution and low toxicity have gained a lot of attention based on their great antiviral activities against different viruses, especially against the life-threatening coronavirus. 104,105 therefore, the discovery of new active compounds to develop anti-inflammatory drugs is an essential step for Covid 19 treatment. Flavonoids like naringenin have been discovered to play potential pharmacological effects.…”

Inhibition of Polyinosinic-Polycytidylic Acid-Induced Acute Pulmonary Inflammation and NF-κB Activation in Mice by a Banana Plant Extract

“…In addition, natural products also contain a variety of active compounds possessing anti-inflammatory activities in repressing the crucial driven cytokine and signaling pathway such as IL-6 and NF (nuclear factor)-κB, respectively 13 . Their therapeutic potential against COVID-19 inflammation also has been noticed and studied 14 . Musa paradisiaca L., prevalently known as banana, is an herbaceous plant of the Musaceae family and the genus Musa .…”

Highly efficient discovery of the covalent M pro inhibitors from crude Pu-erh tea by integrating biochemical and chemoproteomic approaches

“…Notably, some commonly used edible plant in families (such as senna, licorice, ginger, rosemary, and Lonicerae japonicae flos), have now been widely used for attenuating the main clinical symptoms of COVID-19 in most of Chinese families [8,[12][13][14][15] . Increasing studies have demonstrated that parts of natural constituents in plant extracts exhibit various health-promoting effects including anti-oxidative, anti-inflammatory, anti-thrombotic and anti-viral effects, which inspired us to further decipher the anti-SARS-CoV-2 substances in plant extracts, as well as to uncover their anti-SARS-CoV-2 mechanisms [16][17][18][19] .…”