Natural Products and Nutrients against Different Viral Diseases: Prospects in Prevention and Treatment of SARS-CoV-2

Ali, Syed Ahmad; Ansari, Mohammad Azam; Alzohairy, Mohammad A.; Almatroudi, Ahmad; Alomary, Mohammad N.; Alghamdi, Saad; Rehman, Suriya; Khan, Haris M.

doi:10.3390/medicina57020169

Cited by 15 publications

(10 citation statements)

References 94 publications

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“…Hook.f. & Thomson (gilo), isocolumbin, magnoflorin, berberin and tinocordiside, were found to have enhanced binding efficacy for 3CLpro, RdRp, receptor binding domain and glycoprotein ( Ali et al, 2021 ).…”

Section: Natural Products With Antiviral Activitymentioning

confidence: 98%

Natural Compounds With Antimicrobial and Antiviral Effect and Nanocarriers Used for Their Transportation

Stan

Enciu

Mateescu³

et al. 2021

Front. Pharmacol.

120

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Due to the increasing prevalence of life-threatening bacterial, fungal and viral infections and the ability of these human pathogens to develop resistance to current treatment strategies, there is a great need to find and develop new compunds to combat them. These molecules must have low toxicity, specific activity and high bioavailability. The most suitable compounds for this task are usually derived from natural sources (animal, plant or even microbial). In this review article, the latest and most promising natural compounds used to combat bacteria, filamentous fungi and viruses are presented and evaluated. These include plant extracts, essential oils, small antimicrobial peptides of animal origin, bacteriocins and various groups of plant compounds (triterpenoids; alkaloids; phenols; flavonoids) with antimicrobial and antiviral activity. Data are presented on the inhibitory activity of each natural antimicrobial substance and on the putative mechanism of action against bacterial and fungal strains. The results show that among the bioactive compounds studied, triterpenoids have significant inhibitory activity against coronaviruses, but flavonoids have also been shown to inhibit SARS-COV-2. The last chapter is devoted to nanocarriers used to improve stability, bioavailability, cellular uptake/internalization, pharmacokinetic profile and reduce toxicity of natural compunds. There are a number of nanocarriers such as liposomes, drug delivery microemulsion systems, nanocapsules, solid lipid nanoparticles, polymeric micelles, dendrimers, etc. However, some of the recent studies have focused on the incorporation of natural substances with antimicrobial/antiviral activity into polymeric nanoparticles, niosomes and silver nanoparticles (which have been shown to have intrinsic antimicrobial activity). The natural antimicrobials isolated from animals and microorganisms have been shown to have good inhibitory effect on a range of pathogens, however the plants remain the most prolific source. Even if the majority of the studies for the biological activity evaluation are in silico or in vitro, their internalization in the optimum nanocarriers represents the future of “green therapeutics” as shown by some of the recent work in the field.

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Section: Natural Products With Antiviral Activitymentioning

confidence: 98%

Natural Compounds With Antimicrobial and Antiviral Effect and Nanocarriers Used for Their Transportation

Stan

Enciu

Mateescu³

et al. 2021

Front. Pharmacol.

120

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“…Interested researchers should investigate whether potato products can directly suppress infection or reduce the severity of COVID-19 disease. In traditional medicine, especially in Asian countries, numerous herbs or natural remedies are widely used to fight various infections including coronavirus [53,[56][57]. The structure and mechanism of action of different synthetic inhibitors of viral proteases are known [15,58], the role and anti-viral effect of other components has been analyzed [47,53,[58][59][60][61].…”

Section: Regional Diets and Pathogenic Effects Of The Sars-cov-2 Coronavirusmentioning

confidence: 99%

The development and outcomes of the COVID-19 disease correlate with the type of nutrition

Пономаренко¹

2023

Preprint

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Aim. Analyze the role of diet in the process of infection with the SARS-CoV-2 coronavirus and identify factors that correlate with a decrease in the pathogenic consequences of the COVID-19 disease. Materials and methods. The information and data required for this review were found in scientific publications and the media available on the Internet, as well as obtained from statistical databases using specific keywords, both for a single tag, and in various combinations of them. Statistical samples were managed from sources and facts available on the Internet. Results and discussion. The relationship between nutritional factors and the impact of the 15-month COVID-19 pandemic in different regions was investigated using various available statistics for five continents and 47 countries. A clear relationship was found between the prevalence of the SARS-CoV-2 epidemic and the amount of food consumed, with correlations in the negative range r = -0.98 and r = -0.66 for plant proteins and with a correlation coefficient r = 0.92 for animal proteins. Also, excessive sugar consumption increases the severity of COVID-19 with correlation coefficients in the range of r = 0.99-0.72. Conclusions. Quantitative analysis of statistical data and an assessment of nutritional factors during the development of a 15-month pandemic in various regions showed that the severity of the infectious process of the SARS-CoV-2 virus and the COVID-19 disease was aggravated by excessive consumption of sugar, fat and total protein. The number of people infected with the virus or deaths from COVID-19 per 100,000 inhabitants was radically lower in regions where more plant foods were consumed than products of animal origin.

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“…(2021) highlight natural medicines that could be used against SARS-CoV-2 including plants like Glycyrrhiza glabra (licorice), Alnus japonica (alder), Allium sativum (garlic), Houttuynia cordata, Lycoris radiata, Tinospora cordifolia (guduchi) and Vitex trifolia (nirgundi) [33]. Vitamins such as A, B2, B3, B-12, C, D and E, and minerals such as Zinc may have a possible role in SARS-CoV-2 prevention by enhancing immunity.…”

Section: Current Contributionsmentioning

confidence: 99%

The Future of Medicine: Frontiers in Integrative Health and Medicine

2021

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Natural Products and Nutrients against Different Viral Diseases: Prospects in Prevention and Treatment of SARS-CoV-2

Cited by 15 publications

References 94 publications

Natural Compounds With Antimicrobial and Antiviral Effect and Nanocarriers Used for Their Transportation

Natural Compounds With Antimicrobial and Antiviral Effect and Nanocarriers Used for Their Transportation

The development and outcomes of the COVID-19 disease correlate with the type of nutrition

The Future of Medicine: Frontiers in Integrative Health and Medicine

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