Natural Products and Skin Diseases

Majtán, Juraj; Bucekova, Marcela; Jeseňák, Miloš

doi:10.3390/molecules26154489

Cited by 11 publications

(7 citation statements)

References 15 publications

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“…Analgesics [28], anticholinesterase [23], and skin photoprotective activities of fireweed extract were also reported [29]. Recently, some studies also showed wound-healing [30] and cosmetic properties of fireweed [31][32][33].…”

Section: Introductionmentioning

confidence: 93%

Antibacterial and Antimycotic Activity of Epilobium angustifolium L. Extracts: A Review

Dreger,

Adamczak,

Foksowicz-Flaczyk

2023

Pharmaceuticals

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The aim of this work was to provide an overview of available information on the antibacterial and antifungal properties of Epilobium angustifolium extracts. A literature search of Scopus, PubMed/Medline, and Google Scholar for peer-reviewed articles published between January 2000 and June 2023 was undertaken. A total of 23 studies were eligible for inclusion in this review. Significant variation of antimicrobial activity depending on the tested species and strains, type of extract solvent, or plant organs utilized for the extract preparation was found. E. angustifolium extracts were active against both Gram-positive and Gram-negative bacteria and showed antimycotic effects against the fungi of Microsporum canis and Trichophyton tonsurans and the dermatophytes Arthroderma spp. Greater susceptibility of Gram-positive than Gram-negative bacteria to fireweed extracts was found. A strong antibacterial effect was recorded for Staphylococcus aureus, Bacillus cereus, Micrococcus luteus, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter baumannii including multi-drug resistant strains. E. angustifolium extract might find practical application as an antimicrobial in wound healing, components of cosmetic products for human and animals, or as food preservatives.

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Section: Introductionmentioning

confidence: 93%

Antibacterial and Antimycotic Activity of Epilobium angustifolium L. Extracts: A Review

Dreger,

Adamczak,

Foksowicz-Flaczyk

2023

Pharmaceuticals

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“…As a barrier between the internal body and the external environment, the skin may be affected by many conditions such as viral, bacterial, fungal and parasitic infections or UV radiation, that can result in various disorders such as trauma, inflammation, rashes, pigmentation disorders, tumors and even cancer [53]. Nowadays, a wide range of therapeutic methods are used for skin disorders; nevertheless, some of them are limited by adverse reactions, skin barrier or resistance [54].…”

Section: Advanced Technology For Functionalization Of C-pcmentioning

confidence: 99%

“…For example, the excessive use of cleansing cosmetics can disturb the hydrophilic barrier and natural microbiota, cause skin irritations and lead to the atopic skin conditions [54]. This situation is often observed in the inappropriate treatment of acne or self-medication.…”

Section: Advanced Technology For Functionalization Of C-pcmentioning

confidence: 99%

Cyano-Phycocyanin: Mechanisms of Action on Human Skin and Future Perspectives in Medicine

Dranseikienė

Balčiūnaitė-Murzienė

Karosienė

et al. 2022

Plants

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Cyano-phycocyanin is one of the active pigments of the blue-green algae and is usually isolated from the filamentous cyanobacteria Arthrospira platensis Gomont (Spirulina). Due to its multiple physiological functions and non-toxicity, cyano-phycocyanin may be a potential substance for the topical treatment of various skin diseases. Considering that the conventional medicine faces drug resistance, insufficient efficacy and side effects, the plant origin compounds can act as an alternative option. Thus, the aim of this paper was to review the wound healing, antimicrobial, antioxidative, anti-inflammatory, antimelanogenic and anticancer properties and mechanisms of cyano-phycocyanin topical activities on human skin. Moreover, possible applications and biotechnological requirements for pharmaceutical forms of cyano-phycocyanin for the treatment of various skin diseases are discussed in this review.

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“…Their modes of action are anti-inflammatory, anti-bacterial, anti-pigmentating, and anti-wrinkle formation. The effects are mainly explained by biochemical signaling processes, including antioxidant activities [ 32 , 33 ].…”

Section: Introductionmentioning

confidence: 99%

Multiple Effects of Echinochrome A on Selected Ion Channels Implicated in Skin Physiology

et al. 2023

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Echinochrome A (Ech A), a naphthoquinoid pigment from sea urchins, is known to have anti-inflammatory and analgesic effects that have been suggested to be mediated by antioxidant activity and intracellular signaling modulation. In addition to these mechanisms, the ion channels in keratinocytes, immune cells, and nociceptive neurons may be the target for the pharmacological effects. Here, using the patch clamp technique, we investigated the effects of Ech A on the Ca2+-permeable TRPV3, TRPV1 and Orai1 channels and the two-pore domain K+ (K2P) channels (TREK/TRAAK, TASK-1, and TRESK) overexpressed in HEK 293 cells. Ech A inhibited both the TRPV3 and Orai1 currents, with IC50 levels of 2.1 and 2.4 μM, respectively. The capsaicin-activated TRPV1 current was slightly augmented by Ech A. Ech A alone did not change the amplitude of the TREK-2 current (ITREK2), but pretreatments with Ech A markedly facilitated ITREK2 activation by 2-APB, arachidonic acid (AA), and acidic extracellular pH (pHe). Similar facilitation effects of Ech A on TREK-1 and TRAAK were observed when they were stimulated with 2-APB and AA, respectively. On the contrary, Ech A did not affect the TRESK and TASK-1 currents. Interestingly, the ITREK2 maximally activated by the combined application of 2-APB and Ech A was not inhibited by norfluoxetine but was still completely inhibited by ruthenium red. The selective loss of sensitivity to norfluoxetine suggested an altered molecular conformation of TREK-2 by Ech A. We conclude that the Ech A-induced inhibition of the Ca2+-permeable cation channels and the facilitation of the TREK/TRAAK K2P channels may underlie the analgesic and anti-inflammatory effects of Ech A.

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Natural Products and Skin Diseases

Abstract: The skin is the largest multifunctional organ in the human body, serving as an excellent barrier against chemical and biological hazards [...]

Cited by 11 publications

References 15 publications

Antibacterial and Antimycotic Activity of Epilobium angustifolium L. Extracts: A Review

Antibacterial and Antimycotic Activity of Epilobium angustifolium L. Extracts: A Review

Cyano-Phycocyanin: Mechanisms of Action on Human Skin and Future Perspectives in Medicine

Multiple Effects of Echinochrome A on Selected Ion Channels Implicated in Skin Physiology

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