Natural products and synthetic analogues against HIV: A perspective to develop new potential anti-HIV drugs

Popović‐Djordjević, Jelena; Quispe, Cristina; Giordo, Roberta; Kostić, Aleksandar Ž.; Stanković, Jelena S. Katanić; Fokou, Patrick Valère Tsouh; Carbone, Katya; Martorell, Miquel; Kumar, Manoj; Pintus, Gianfranco; Sharifi‐Rad, Javad; Docea, Anca Oana; Calina, Daniela

doi:10.1016/j.ejmech.2022.114217

Cited by 42 publications

(23 citation statements)

References 166 publications

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“…Although natural products show excellent results in vitro, the development of cytostatic drugs in them is a complex process, except for a few. The therapeutic advantage of these natural products is their minimal toxicity and reduced side effects [ 92 , 128 , 129 ]. But natural bioactive compounds can interact with many proteins, which is why it is very important to elucidate the mechanisms of action of natural products, especially those that are used in our diet [ 130 ].…”

Section: Limitations and Future Perspectivesmentioning

confidence: 99%

Targeting Ras-ERK cascade by bioactive natural products for potential treatment of cancer: an updated overview

Ali

Akter

Ramproshad³

et al. 2022

Cancer Cell Int

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MAPK (mitogen-activated protein kinase) or ERK (extracellular-signal-regulated kinase) pathway is an important link in the transition from extracellular signals to intracellular responses. Because of genetic and epigenetic changes, signaling cascades are altered in a variety of diseases, including cancer. Extant studies on the homeostatic and pathologic behavior of MAPK signaling have been conducted; however, much remains to be explored in preclinical and clinical research in terms of regulation and action models. MAPK has implications for cancer therapy response, more specifically in response to experimental MAPK suppression, compensatory mechanisms are activated. The current study investigates MAPK as a very complex cell signaling pathway that plays roles in cancer treatment response, cellular normal conduit maintenance, and compensatory pathway activation. Most MAPK inhibitors, unfortunately, cause resistance by activating compensatory feedback loops in tumor cells and tumor microenvironment components. As a result, innovative combinatorial treatments for cancer management must be applied to limit the likelihood of alternate pathway initiation as a possibility for generating novel therapeutics based on incorporation in translational research. We summarize current knowledge about the implications of ERK (MAPK) in cancer, as well as bioactive products from plants, microbial organisms or marine organisms, as well as the correlation with their chemical structures, which modulate this pathway for the treatment of different types of cancer.

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Section: Limitations and Future Perspectivesmentioning

confidence: 99%

Targeting Ras-ERK cascade by bioactive natural products for potential treatment of cancer: an updated overview

Ali

Akter

Ramproshad³

et al. 2022

Cancer Cell Int

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“…One strategy involves using compounds derived from edible dietary plants, seeds and traditional medicinal herbs that have an impact on not only treating but also preventing cancer, either alone or along with existing treatment approaches [ 4 – 6 ]. Natural medicines which are derived from medicinal herbs or different vegetables or plants and fruits with promising health benefits are proved to be effective in treating and also preventing a wide range of human ailments, including obesity, neurological disorders, cancer, metabolic syndromes, cardiovascular disease, and diabetes [ 7 – 10 ]. A recent review by Newman and Cragg [ 11 ] reported the various natural products as a source of safe drugs for the treatment of various ailments in humans [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Diosgenin: An Updated Pharmacological Review and Therapeutic Perspectives

Semwal

Painuli

Abu-Izneid

et al. 2022

Oxidative Medicine and Cellular Longevity

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Plants including Rhizoma polgonati, Smilax china, and Trigonella foenum-graecum contain a lot of diosgenin, a steroidal sapogenin. This bioactive phytochemical has shown high potential and interest in the treatment of various disorders such as cancer, diabetes, arthritis, asthma, and cardiovascular disease, in addition to being an important starting material for the preparation of several steroidal drugs in the pharmaceutical industry. This review aims to provide an overview of the in vitro, in vivo, and clinical studies reporting the diosgenin’s pharmacological effects and to discuss the safety issues. Preclinical studies have shown promising effects on cancer, neuroprotection, atherosclerosis, asthma, bone health, and other pathologies. Clinical investigations have demonstrated diosgenin’s nontoxic nature and promising benefits on cognitive function and menopause. However, further well-designed clinical trials are needed to address the other effects seen in preclinical studies, as well as a better knowledge of the diosgenin’s safety profile.

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“…Hycamtin ® ) [24][25][26]. After a decline in the pharmaceutical industry's search for natural products from the 1990s onwards due to technical barriers to screening, isolation, characterization and optimization, in recent years, technological and scientific development has revitalized the interest in them [27,28]. According to Newman & Cragg [26], natural products still offer the best potential for discovering new compounds that can lead to effective agents in a variety of human diseases.…”

Section: Introductionmentioning

confidence: 99%

Natural essential oils as a new therapeutic tool in colorectal cancer

et al. 2022

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Colorectal cancer (CRC) is the third most revalent type of cancer in the world and the second most common cause of cancer death (about 1 million per year). Historically, natural compounds and their structural analogues have contributed to the development of new drugs useful in the treatment of various diseases, including cancer. Essential oils are natural odorous products made up of a complex mixture of low molecular weight compounds with recognized biological and pharmacological properties investigated also for the prevention and treatment of cancer. The aim of this paper is to highlight the possible role of essential oils in CRC, their composition and the preclinical studies involving them. It has been reviewed the preclinical pharmacological studies to determine the experimental models used and the anticancer potential mechanisms of action of natural essential oils in CRC. Searches were performed in the following databases PubMed/Medline, Web of science, TRIP database, Scopus, Google Scholar using appropriate MeSH terms. The results of analyzed studies showed that EOs exhibited a wide range of bioactive effects like cytotoxicity, antiproliferative, and antimetastatic effects on cancer cells through various mechanisms of action. This updated review provides a better quality of scientific evidence for the efficacy of EOs as chemotherapeutic/chemopreventive agents in CRC. Future translational clinical studies are needed to establish the effective dose in humans as well as the most suitable route of administration for maximum bioavailability and efficacy. Given the positive anticancer results obtained from preclinical pharmacological studies, EOs can be considered efficient complementary therapies in chemotherapy in CRC.

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Natural products and synthetic analogues against HIV: A perspective to develop new potential anti-HIV drugs

Cited by 42 publications

References 166 publications

Targeting Ras-ERK cascade by bioactive natural products for potential treatment of cancer: an updated overview

Targeting Ras-ERK cascade by bioactive natural products for potential treatment of cancer: an updated overview

Diosgenin: An Updated Pharmacological Review and Therapeutic Perspectives

Natural essential oils as a new therapeutic tool in colorectal cancer

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