Natural products and their derivatives as anti-flavivirus drug candidates

Ponciano, Carolina Sousa; Ávila, Eloah Pereira; Grazul, Richard Michael; Mendes, Larissa Albuquerque de Oliveira; Almeida, Mauro Vieira de

doi:10.1007/s00044-021-02718-5

Cited by 3 publications

(1 citation statement)

References 146 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Flavonoids are secondary metabolites with varied medicinal properties, found in fruits, flowers and leaves of various plants. They have a phenolic structure containing skeleton with 15 carbon atoms in which an aromatic ring is fused with a heterocyclic ring attached to another heterocyclic ring, and are subdivided into six main groups: flavonols, flavanones, flavones, flavonoids, isoflavones and anthocyanins [83,84].…”

Section: Flavonoidsmentioning

confidence: 99%

Natural Products and Synthetic Derivatives as Promising Candidates Against Neglected Tropical Diseases

Fuzaro

Ponciano

Barros

et al. 2022

Orbital: Electron. J. Chem.

View full text Add to dashboard Cite

Neglected Tropical Diseases (NTD) are a group of endemic diseases that cause up to one million deaths annually. Leishmaniasis and Chagas Disease are classified as NTD whose current treatments are of limited access. There is an urgent need to develop new agents to combat or alleviate the symptoms of these pathologies. The present work highlights the activities of several natural products and their derivatives which have been tested against the causative parasites of both diseases. The activities of natural products illustrate their potential to assist in the combat against NTD. Research in this area could provide an opportunity to advance medical research and to provide treatments to low- and middle-income countries.

show abstract

Section: Flavonoidsmentioning

confidence: 99%