Natural products from mangrove sediments-derived microbes: Structural diversity, bioactivities, biosynthesis, and total synthesis

Li, Kunlong; Chen, Siqiang; Pang, Xiaoyan; Cai, Jian; Zhang, Xinya; Liu, Yonghong; Zhu, Yiguang; Zhou, Xuefeng

doi:10.1016/j.ejmech.2022.114117

Cited by 47 publications

(38 citation statements)

References 312 publications

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“…Microorganisms from mangrove soils or sediments are valuable source of metabolites with many novel chemical structures and catalytic functions. A report ( Li et al, 2022 ) provided a comprehensive overview of 519 natural products isolated from mangrove sediments microbes and their bioactivities up to 2021, revealing that mangrove sediments microbes are an important reservoir of novel bioactive substances with considerable potential for application.…”

Section: Discussionmentioning

confidence: 99%

Isolation, characterization, and genome sequencing of a novel chitin deacetylase producing Bacillus aryabhattai TCI-16

Liang

Yan²,

Tan³

et al. 2022

Front. Microbiol.

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Chitin deacetylase (CDA) is a chitin degradation enzyme that catalyzes the conversion of chitin to chitosan by the deacetylation of N-acetyl-D-glucosamine residues, playing an important role in the high-value utilization of waste chitin. The shells of shrimp and crab are rich in chitin, and mangroves are usually recognized as an active habitat to shrimp and crab. In the present study, a CDA-producing bacterium, strain TCI-16, was isolated and screened from the mangrove soil. Strain TCI-16 was identified and named as Bacillus aryabhattai TCI-16, and the maximum CDA activity in fermentation broth reached 120.35 ± 2.40 U/mL at 36 h of cultivation. Furthermore, the complete genome analysis of B. aryabhattai TCI-16 revealed the chitin-degrading enzyme system at genetic level, in which a total of 13 putative genes were associated with carbohydrate esterase 4 (CE4) family enzymes, including one gene coding CDA, seven genes encoding polysaccharide deacetylases, and five genes encoding peptidoglycan-N-acetyl glucosamine deacetylases. Amino acid sequence analysis showed that the predicted CDA of B. aryabhattai TCI-16 was composed of 236 amino acid residues with a molecular weight of 27.3 kDa, which possessed a conserved CDA active like the known CDAs. However, the CDA of B. aryabhattai TCI-16 showed low homology (approximately 30%) with other microbial CDAs, and its phylogenetic tree belonged to a separate clade in bacteria, suggesting a high probability in structural novelty. In conclusion, the present study indicated that the novel CDA produced by B. aryabhattai TCI-16 might be a promising option for bioconversion of chitin to the value-added chitosan.

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Section: Discussionmentioning

confidence: 99%

Isolation, characterization, and genome sequencing of a novel chitin deacetylase producing Bacillus aryabhattai TCI-16

Liang

Yan²,

Tan³

et al. 2022

Front. Microbiol.

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“…The variety and complexity of the mangrove soil environment leads to the diversity of soil microorganisms ( He et al, 2019 ). Mangrove soil or sediment-derived microbes play an essential role in maintaining the biosphere balance and are also a prolific source of structurally unique and novel bioactive secondary metabolites ( Li et al, 2022 ). Mainly derived from marine fungi, thiodiketopiperazines have been recently reported to have a broad range of significant biological activities, such as brine shrimp lethality ( Liu et al, 2015a ), antibacterial ( Liu et al, 2015a ), antifungal ( Liu et al, 2015b ), cytotoxic ( Yurchenko et al, 2016 ), and C-terminal inhibitor ( Dai et al, 2019 ) activities.…”

Section: Introductionmentioning

confidence: 99%

Thiodiketopiperazines and Alkane Derivatives Produced by the Mangrove Sediment–Derived Fungus Penicillium ludwigii SCSIO 41408

et al. 2022

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A new trithiodiketopiperazine derivative, adametizine C (1), and five new alkane derivatives (7–11), were isolated from the mangrove sediment–derived fungus Penicillium ludwigii SCSIO 41408, together with five known dithiodiketopiperazine derivatives (2–6). Their structures were elucidated on the basis of spectroscopic analysis, and the absolute configuration of 1 was determined by X-ray crystallographic analysis. In a variety of bioactivity screening, 1–5 exhibited some selective antifungal or antibacterial activities. Compounds 1–3 showed cytotoxicity against prostate cancer cell line 22Rv1 with half maximal inhibitory concentration (IC50) values of 13.0–13.9 μM; moreover, 3 showed obvious activity against another prostate cancer PC-3 cells with an IC50 value of 5.1 μM. Further experiments revealed that 3 could significantly reduce PC-3 cells colony formation and induce apoptosis in a dose-dependent manner. Several compounds also exhibited obvious inhibitory activities of lipopolysaccharide–induced nuclear factor-κB with IC50 values range from 8.2 to 21.5 μM, and 1, 5, and 9 were further evaluated for their effects on receptor activator of NF-κB ligand (RANKL)-induced osteoclastogenesis. Adametizine C (1), with the strongest inhibitory activity against RANKL-induced osteoclast differentiation in bone marrow macrophage cells with 10 μM, was suggested to be the promising lead compound for the treatment of osteoclast-related diseases.

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“…A large number of structurally unusual and bioactive NPs have been discovered from the mangrove-associated microorganisms, including fungal and bacterial endophytes isolated from the mangrove plants’ leaves, branches, and roots [ 13 , 14 ]. In addition, Mangrove sediments-derived microbes, a rich reservoir of NP diversity, could be utilized to explore new drugs [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

“…However, the investigation of the mangrove ecosystem is mainly focused on the mangrove-associated microorganism but less on the mangrove flora in recent years. Three comprehensive reviews have recently focused on the NPs from mangrove-associated fungi and mangrove sediments-derived microbes [ 6 , 14 , 15 ]. However, to our knowledge, no review has been published on the secondary metabolites with unusual skeletons from the mangrove ecosystem.…”

Section: Introductionmentioning

confidence: 99%

Unusual Secondary Metabolites from the Mangrove Ecosystems: Structures, Bioactivities, Chemical, and Bio-Syntheses

Guo

2022

Marine Drugs

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Mangrove ecosystems are widely distributed in the intertidal zone of tropical and subtropical estuaries or coasts, containing abundant biological communities, for example, mangrove plants and diverse groups of microorganisms, featuring various bioactive secondary metabolites. We surveyed the literature from 2010 to 2022, resulting in a collection of 134 secondary metabolites, and classified them into two major families in terms of the biological sources and 15 subfamilies according to the chemical structures. To highlight the structural diversity and bioactivities of the mangrove ecosystem-associated secondary metabolites, we presented the chemical structures, bioactivities, biosynthesis, and chemical syntheses.

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Natural products from mangrove sediments-derived microbes: Structural diversity, bioactivities, biosynthesis, and total synthesis

Cited by 47 publications

References 312 publications

Isolation, characterization, and genome sequencing of a novel chitin deacetylase producing Bacillus aryabhattai TCI-16

Isolation, characterization, and genome sequencing of a novel chitin deacetylase producing Bacillus aryabhattai TCI-16

Thiodiketopiperazines and Alkane Derivatives Produced by the Mangrove Sediment–Derived Fungus Penicillium ludwigii SCSIO 41408

Unusual Secondary Metabolites from the Mangrove Ecosystems: Structures, Bioactivities, Chemical, and Bio-Syntheses

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