Natural Products from Plants

Kaufman, Peter B.; Cseke, Leland J.; Warber, Sara; Brielmann, Harry; Düke, James A.

doi:10.1201/9781420049350

Cited by 35 publications

(41 citation statements)

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“…The natural products as medicinal agents presumably predate the earliest recorded history as the earliest humans used various, but specific plants to treat illness [1]. The genus Piper is among the medicinal plants comprised of an estimated 2000 species [2].…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Studies of the Ethyl Acetate Extract of the Fruit of Piper capense

Arega¹

2018

J Pharmacogn Nat Prod

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Natural products have been a major source of drugs for centuries. The fruit of Piper capense is used traditionally as spice and for the treatment of infectious diseases in different parts of Ethiopia. The main objective of this work is to carry out phytochemical study of the EtOAc crude extract of the fruit of P. capense. Phytochemical screening on this crude extract revealed the presence of phenols, alkaloids, steroids, terpenes, saponins and flavonoids. After silica gel column chromatography the crude extract led to the isolation of compound PC1 identified as 5-Hydroxy-7, 4'-dimethoxyflavone. Characterization of this compound was achieved via spectroscopic methods (NMR, UV and IR). The structure of compound PC2 was elucidated, the spectral data showed the presence of more than one compound one of which is partially characterized and proposed to be rotenone.

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Section: Introductionmentioning

confidence: 99%

Phytochemical Studies of the Ethyl Acetate Extract of the Fruit of Piper capense

Arega¹

2018

J Pharmacogn Nat Prod

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“…Plant secondary products also have protective actions in relation to abiotic stresses such as those associated with changes in temperature, water status, light levels, UV exposure, and mineral nutrients (Kaufman et al, 1999). Furthermore, recent work has indicated potential roles of secondary products at the cellular level as plant growth regulators, modulators of gene expression, and in signal transduction (Kaufman et al, 1999).…”

Section: Phytomedicinal Actions Often Results From Secondary Products mentioning

confidence: 99%

“…That the medicinal actions of plants are unique to particular plant species or groups is consistent with this concept as the combinations of secondary products in a particular plant are often taxonomically distinct (Wink, 1999). This is in contrast to primary products, such as carbohydrates, lipids, proteins, heme, chlorophyll, and nucleic acids, which are common to all plants and are involved in the primary metabolic processes of building and maintaining plant cells (Kaufman et al, 1999;Wink, 1999). Although plant secondary products have historically been defined as chemicals that do not appear to have a vital biochemical role in the process of building and maintaining plant cells, recent research has shown a pivotal role of these chemicals in the ecophysiology of plants.…”

Section: Phytomedicinal Actions Often Results From Secondary Products mentioning

confidence: 99%

“…Although plant secondary products have historically been defined as chemicals that do not appear to have a vital biochemical role in the process of building and maintaining plant cells, recent research has shown a pivotal role of these chemicals in the ecophysiology of plants. Accordingly, secondary products have both a defensive role against herbivory, pathogen attack, and inter-plant competition and an attractant role toward beneficial organisms such as pollinators or symbionts (Kaufman et al, 1999;Wink and Schimmer, 1999). Plant secondary products also have protective actions in relation to abiotic stresses such as those associated with changes in temperature, water status, light levels, UV exposure, and mineral nutrients (Kaufman et al, 1999).…”

Section: Phytomedicinal Actions Often Results From Secondary Products mentioning

confidence: 99%

“…Accordingly, secondary products have both a defensive role against herbivory, pathogen attack, and inter-plant competition and an attractant role toward beneficial organisms such as pollinators or symbionts (Kaufman et al, 1999;Wink and Schimmer, 1999). Plant secondary products also have protective actions in relation to abiotic stresses such as those associated with changes in temperature, water status, light levels, UV exposure, and mineral nutrients (Kaufman et al, 1999). Furthermore, recent work has indicated potential roles of secondary products at the cellular level as plant growth regulators, modulators of gene expression, and in signal transduction (Kaufman et al, 1999).…”

Section: Phytomedicinal Actions Often Results From Secondary Products mentioning

confidence: 99%

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Medicinal Plants and Phytomedicines. Linking Plant Biochemistry and Physiology to Human Health

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rac‐ and meso‐Cyclohexanoids: Their α‐, β‐glycosidases, antibacterial, antifungal activities, and molecular docking studies

Karakılıç

Baran

Öğütçü

et al. 2020

Archiv der Pharmazie

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An efficient and versatile synthesis method has been postulated for hydroxymethylated rac‐ and meso‐cyclohexanoid derivatives. The synthesis of these stereoisomers was achieved easily with traditional methods using hexahydroisobenzofuran 6, prepared from commercially available cis‐hydrophthalic anhydride. The study, involving diastereoselective epoxidation and cis‐hydroxylation, was conducted to obtain epoxy‐, cis‐, and trans‐diol‐furans 7, 8, and 9. After sulfamic acid‐catalyzed ring‐opening reaction of the epoxide and furan rings, rac‐ and meso‐tetraacetates 14, 15, and 16 were afforded. Hydrolysis of acetate groups with ammonia in absolute methanol yielded the desired tetrols rac‐17, meso‐18, and meso‐19. All structures, after purification by chromatographic methods and elucidation by spectral techniques, were screened against α‐ and β‐glucosidases. Compounds 7, 8, 10, 17, 18, and 19 were also evaluated for their antibacterial and antifungal activity against some selected synthesized compounds with varying degrees of inhibitory effects on the growth of different pathogenic microorganisms by the well‐diffusion method. In addition, Saccharomyces cerevisiae α‐glucosidase molecular modeling studies were performed for all rac‐ and meso‐compounds 7, 8, 10, 17, 18, and 19.

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Natural Products from Plants

Cited by 35 publications

References 0 publications

Phytochemical Studies of the Ethyl Acetate Extract of the Fruit of Piper capense

Phytochemical Studies of the Ethyl Acetate Extract of the Fruit of Piper capense

Medicinal Plants and Phytomedicines. Linking Plant Biochemistry and Physiology to Human Health

rac‐ and meso‐Cyclohexanoids: Their α‐, β‐glycosidases, antibacterial, antifungal activities, and molecular docking studies

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