Natural products in the management of schistosomiasis

Shaikh, Tanvir Yusuf; Baviskar, Kiran D.; Jain, P.K.; Shah, Kamal; Kori, Mohan Lal; Lodhi, Santram

doi:10.1016/b978-0-323-91942-5.00020-3

Natural Products in Vector-Borne Disease Management 2023

DOI: 10.1016/b978-0-323-91942-5.00020-3

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Natural products in the management of schistosomiasis

Tanvir Yusuf Shaikh¹,

Kiran D. Baviskar²,

P.K. Jain³

et al.

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2023

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Cited by 1 publication

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Validation of phytochemicals from Houttuynia cordata for their effect on dipeptidyl peptidase IV and sodium/glucose cotransporter 2: an in silico study

Pakyntein

Thabah

Syiem

et al. 2023

Preprint

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The study identified and screened phytochemicals present in Houttuynia cordata and characterized their ADME/Tox properties. The powdered plant extracted using water and methanol for about 24h was refluxed, filtered, and evaporated to dryness under reduced pressure and subjected to High-Performance Thin Layer Chromatography, and Gas Chromatography tandem mass spectrometry analysis using a standard protocol. The compounds identified from Houttuynia cordata were docked with antidiabetic targets- dipeptidyl peptidase-IV and sodium/glucose cotransporter 2. High-Performance Thin Layer Chromatography and Gas Chromatography tandem mass spectrometry analysis showed the presence of several compounds by matching their recorded spectra with the data bank mass spectra from the NIST library. ADME/Tox properties and docking of the identified compounds indicate the potentiality of the compounds as drug candidates. Selected compounds from Houttuynia cordata have good pharmacokinetic properties and binding affinity for DPP-IV and SGLT2. However, the isolation of these phytoconstituents and their in vivo activity will help give a better insight and will open a new area of investigation of individual components and their pharmacological potency.

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Validation of phytochemicals from Houttuynia cordata for their effect on dipeptidyl peptidase IV and sodium/glucose cotransporter 2: an in silico study

Pakyntein

Thabah

Syiem

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

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Natural products in the management of schistosomiasis

Cited by 1 publication

References 135 publications

Validation of phytochemicals from Houttuynia cordata for their effect on dipeptidyl peptidase IV and sodium/glucose cotransporter 2: an in silico study

Validation of phytochemicals from Houttuynia cordata for their effect on dipeptidyl peptidase IV and sodium/glucose cotransporter 2: an in silico study

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