Natural Products with Anti-obesity Effects and Different Mechanisms of Action

Abstract

Obesity, a primary influence on health condition, causes numerous comorbidities and complications and, therefore, pharmacotherapy is considered a strategy for its treatment. However, the adverse effects of most chemical drugs targeting weight loss complicate their approval by regulatory authorities. Recently, interest has increased in the development of ingredients from natural sources with fewer adverse effects for preventing and ameliorating obesity. This review provides an overview of current anti-obesity drugs and natural products with anti-obesity properties as well as their mechanisms of action, which include interfering with nutrient absorption, decreasing adipogenesis, increasing energy expenditure (thermogenesis), appetite suppression, modifying intestinal microbiota composition, and increasing fecal fat excretion.

Evaluation of the impact of different drying methods on the phenolic compounds, antioxidant activity, and in vitro digestion of green coffee beans

“…The inhibition of nutrient digestion and absorption is one of the effective strategies to prevent obesity and type 2 diabetes. In previous studies, inhibition of the activity of pancreatic lipase, α-glucosidase, and α-amylase, which are involved in dietary carbohydrate and lipid degradation, has been found to be positively correlated with reduced fat and sugar absorption from the gastrointestinal tract (Fu, Jiang, Guo, & Su, 2016;Kumar, Narwal, Kumar, & Prakash, 2011;Sales, Souza, Simeoni, Magalhães, & Silveira, 2012). It has been reported that modest coffee intake can slow down diabetes.…”

Physiological process of fat loss

“…A purified extract of Hoodia, known as P57, was injected in an in vivo study directly into the brains of rats and easily broken down by the liver (Spadafranca et al 2013). However, an in vitro study was found that P57 was generally not inhibited metabolically by human liver enzymes and has a relatively high secretion rate (Fu et al 2016).…”

6-Acetyl-2,2-Dimethylchroman-4-One Isolated from Artemisia princeps Suppresses Adipogenic Differentiation of Human Bone Marrow-Derived Mesenchymal Stromal Cells via Activation of AMPK

“…7 Phytochemicals are one of the possible ways to regulate the energy metabolism and lower the risks of developing obesityrelated complications. [8][9][10] To date, studies have reported several plants with substances that can inhibit adipogenesis with different action mechanisms. In this context, Artemisia species have produced different results in terms of their effects on adipogenesis.…”